Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo

Background: To stabilize Graves disease and deplete the preformed hormone, the use of antithyroid drugs prior 131I therapy has been suggested, specially in those patients with severe thyrotoxicosis and in the elderly. However, PTU may reduce the effectiveness of 131I. Aim: To study the effects of PT...

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Autores principales:	Véliz L,Jesús, Pineda V,Gustavo, Arancibia Z,Paulina, Wohllk G,Nelson
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Goiter Hyperthyroidism Iodine radioisotopes Propylthiouracil Thyroid disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600006
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spelling	oai:scielo:S0034-988720000006000062005-11-14Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuraciloVéliz L,JesúsPineda V,GustavoArancibia Z,PaulinaWohllk G,Nelson Goiter Hyperthyroidism Iodine radioisotopes Propylthiouracil Thyroid disease Background: To stabilize Graves disease and deplete the preformed hormone, the use of antithyroid drugs prior 131I therapy has been suggested, specially in those patients with severe thyrotoxicosis and in the elderly. However, PTU may reduce the effectiveness of 131I. Aim: To study the effects of PTU pretreatment before 131I administration. Subjets and methods: A retrospective analysis of the medical records of patients with Graves disease treated with 131I from 1989 to 1997 was made. Of 244 patients with adequate follow-up for at least 12 months after 131I treatment, 142 had not been pretreated and 102 had received PTU prior to 131I therapy. Pretreated patients were distributed according to the number of days that PTU was discontinued before reciving 131I, forming four groups (a=5d, b=6-14 d, c=15-30 d and d=31-60 d). Radioiodine was delivered according to our protocol of 120 µCi per gram of thyroid tissue, as estimated by clinical examination. Therapy was considered successful when laboratory evidence of euthyroidism or hypothyroidism after one year of treatment was obtained and as a failure when undetectable TSH values persisted after 12 months of treatment with 131I. Results: All groups were comparable as to age, gender, goiter size, and 24 h radioiodine uptake. Control of hyperthyroidism was achieved in 76% of the non pretreated group. A similar percentage was observed in groups (b), (c) and (d). However, the disease was controlled in only 50% of group (a) patients (p <0.003). Conclusions: The therapeutic efficacy of 131I is significantly reduced when the PTU is stopped for only a few days prior to the use of radioiodine. We postulate that PTU has to be discontinued for at least 10 days before radioiodine administration. (Rev Méd Chile 2000; 128: 609-12).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.6 20002000-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600006es10.4067/S0034-98872000000600006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Goiter Hyperthyroidism Iodine radioisotopes Propylthiouracil Thyroid disease
spellingShingle	Goiter Hyperthyroidism Iodine radioisotopes Propylthiouracil Thyroid disease Véliz L,Jesús Pineda V,Gustavo Arancibia Z,Paulina Wohllk G,Nelson Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
description	Background: To stabilize Graves disease and deplete the preformed hormone, the use of antithyroid drugs prior 131I therapy has been suggested, specially in those patients with severe thyrotoxicosis and in the elderly. However, PTU may reduce the effectiveness of 131I. Aim: To study the effects of PTU pretreatment before 131I administration. Subjets and methods: A retrospective analysis of the medical records of patients with Graves disease treated with 131I from 1989 to 1997 was made. Of 244 patients with adequate follow-up for at least 12 months after 131I treatment, 142 had not been pretreated and 102 had received PTU prior to 131I therapy. Pretreated patients were distributed according to the number of days that PTU was discontinued before reciving 131I, forming four groups (a=5d, b=6-14 d, c=15-30 d and d=31-60 d). Radioiodine was delivered according to our protocol of 120 µCi per gram of thyroid tissue, as estimated by clinical examination. Therapy was considered successful when laboratory evidence of euthyroidism or hypothyroidism after one year of treatment was obtained and as a failure when undetectable TSH values persisted after 12 months of treatment with 131I. Results: All groups were comparable as to age, gender, goiter size, and 24 h radioiodine uptake. Control of hyperthyroidism was achieved in 76% of the non pretreated group. A similar percentage was observed in groups (b), (c) and (d). However, the disease was controlled in only 50% of group (a) patients (p <0.003). Conclusions: The therapeutic efficacy of 131I is significantly reduced when the PTU is stopped for only a few days prior to the use of radioiodine. We postulate that PTU has to be discontinued for at least 10 days before radioiodine administration. (Rev Méd Chile 2000; 128: 609-12).
author	Véliz L,Jesús Pineda V,Gustavo Arancibia Z,Paulina Wohllk G,Nelson
author_facet	Véliz L,Jesús Pineda V,Gustavo Arancibia Z,Paulina Wohllk G,Nelson
author_sort	Véliz L,Jesús
title	Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
title_short	Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
title_full	Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
title_fullStr	Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
title_full_unstemmed	Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
title_sort	tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600006
work_keys_str_mv	AT velizljesus tratamientoconradioyododelbociodifusohipertiroideoinfluenciadelpretratamientoconpropiltiuracilo AT pinedavgustavo tratamientoconradioyododelbociodifusohipertiroideoinfluenciadelpretratamientoconpropiltiuracilo AT arancibiazpaulina tratamientoconradioyododelbociodifusohipertiroideoinfluenciadelpretratamientoconpropiltiuracilo AT wohllkgnelson tratamientoconradioyododelbociodifusohipertiroideoinfluenciadelpretratamientoconpropiltiuracilo
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Tratamiento con radioyodo del bocio difuso hipertiroideo: influencia del pretratamiento con propiltiuracilo

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