Disfunción endotelial como alteración primaria en las patologías vasculares

Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In add...

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Autores principales:	Irribarra P,Verónica, Germain A,Alfredo, Cuevas M,Ada, Faúndez G,Lorena, Valdés S,Gloria
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Endothelins Endothelium-derived relaxing factor Endothelium, vascular
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600014
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id	oai:scielo:S0034-98872000000600014
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spelling	oai:scielo:S0034-988720000006000142005-11-14Disfunción endotelial como alteración primaria en las patologías vascularesIrribarra P,VerónicaGermain A,AlfredoCuevas M,AdaFaúndez G,LorenaValdés S,Gloria Endothelins Endothelium-derived relaxing factor Endothelium, vascular Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In addition, the endothelium may increase the release of NO in response to humoral stimulation by vasoactive substances such as acetylcholine, bradikinin or substance P. Although the endothelium releases a number of products, no single blood test has yet proved useful to determine normal endothelial function or as early abnormalities. The most useful test of endothelial function relies on the meassurement of endothelium-dependent dilatation in response to pharmacological or physiologic stimuli. The alteration of this response is known as endothelial dysfunction and has been observed in a variety of circumstances related to cardiovascular risk. This review summarizes the evidence that sustains this association and emphasizes the clinical utility of assessing endothelial function presenting two clinical cases of hypercholesterolemia in which a high-resolution vascular ultrasound in the braquial artery was used. (Rev Méd Chile 2000; 128: 659-70).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.6 20002000-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600014es10.4067/S0034-98872000000600014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endothelins Endothelium-derived relaxing factor Endothelium, vascular
spellingShingle	Endothelins Endothelium-derived relaxing factor Endothelium, vascular Irribarra P,Verónica Germain A,Alfredo Cuevas M,Ada Faúndez G,Lorena Valdés S,Gloria Disfunción endotelial como alteración primaria en las patologías vasculares
description	Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In addition, the endothelium may increase the release of NO in response to humoral stimulation by vasoactive substances such as acetylcholine, bradikinin or substance P. Although the endothelium releases a number of products, no single blood test has yet proved useful to determine normal endothelial function or as early abnormalities. The most useful test of endothelial function relies on the meassurement of endothelium-dependent dilatation in response to pharmacological or physiologic stimuli. The alteration of this response is known as endothelial dysfunction and has been observed in a variety of circumstances related to cardiovascular risk. This review summarizes the evidence that sustains this association and emphasizes the clinical utility of assessing endothelial function presenting two clinical cases of hypercholesterolemia in which a high-resolution vascular ultrasound in the braquial artery was used. (Rev Méd Chile 2000; 128: 659-70).
author	Irribarra P,Verónica Germain A,Alfredo Cuevas M,Ada Faúndez G,Lorena Valdés S,Gloria
author_facet	Irribarra P,Verónica Germain A,Alfredo Cuevas M,Ada Faúndez G,Lorena Valdés S,Gloria
author_sort	Irribarra P,Verónica
title	Disfunción endotelial como alteración primaria en las patologías vasculares
title_short	Disfunción endotelial como alteración primaria en las patologías vasculares
title_full	Disfunción endotelial como alteración primaria en las patologías vasculares
title_fullStr	Disfunción endotelial como alteración primaria en las patologías vasculares
title_full_unstemmed	Disfunción endotelial como alteración primaria en las patologías vasculares
title_sort	disfunción endotelial como alteración primaria en las patologías vasculares
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000600014
work_keys_str_mv	AT irribarrapveronica disfuncionendotelialcomoalteracionprimariaenlaspatologiasvasculares AT germainaalfredo disfuncionendotelialcomoalteracionprimariaenlaspatologiasvasculares AT cuevasmada disfuncionendotelialcomoalteracionprimariaenlaspatologiasvasculares AT faundezglorena disfuncionendotelialcomoalteracionprimariaenlaspatologiasvasculares AT valdessgloria disfuncionendotelialcomoalteracionprimariaenlaspatologiasvasculares
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Disfunción endotelial como alteración primaria en las patologías vasculares

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