Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico
Background: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldo...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Lenguaje: | Spanish / Castilian |
| Publicado: |
Sociedad Médica de Santiago
2000
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900001 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0034-98872000000900001 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0034-988720000009000012005-11-15Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnósticoCortés P,PaolaFardella B,CarlosOestreicher C,EvelineGac E,HomeroMosso G,LorenaSoto M,JuliaForadori C,ArnaldoClaverie R,XimenaAhuad N,JessicaMontero L,Joaquín Aldosterone Hyperaldosteronism Hypertension Background: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects. Patients and methods: One hundred twenty five subjects with essential hypertension, not receiving medications for at least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium. Results: Plasma aldosterone was higher in hypertensive subjects than controls (11.6 ± 7.6 and 9.9 ± 5.1 ng/dl respectively; p=0.04). Plasma renin activity was lower in hypertensives than controls (1.42 ± 1.28 and 1.88 ± 1.39 ng/ml/h respectively; p<0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 ± 13.5 and 8.3 ± 7.8; p<0.001). A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia. Conclusions: Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal. (Rev Méd Chile 2000; 128: 955-61)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.9 20002000-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900001es10.4067/S0034-98872000000900001 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Aldosterone Hyperaldosteronism Hypertension |
| spellingShingle |
Aldosterone Hyperaldosteronism Hypertension Cortés P,Paola Fardella B,Carlos Oestreicher C,Eveline Gac E,Homero Mosso G,Lorena Soto M,Julia Foradori C,Arnaldo Claverie R,Ximena Ahuad N,Jessica Montero L,Joaquín Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| description |
Background: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects. Patients and methods: One hundred twenty five subjects with essential hypertension, not receiving medications for at least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium. Results: Plasma aldosterone was higher in hypertensive subjects than controls (11.6 ± 7.6 and 9.9 ± 5.1 ng/dl respectively; p=0.04). Plasma renin activity was lower in hypertensives than controls (1.42 ± 1.28 and 1.88 ± 1.39 ng/ml/h respectively; p<0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 ± 13.5 and 8.3 ± 7.8; p<0.001). A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia. Conclusions: Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal. (Rev Méd Chile 2000; 128: 955-61) |
| author |
Cortés P,Paola Fardella B,Carlos Oestreicher C,Eveline Gac E,Homero Mosso G,Lorena Soto M,Julia Foradori C,Arnaldo Claverie R,Ximena Ahuad N,Jessica Montero L,Joaquín |
| author_facet |
Cortés P,Paola Fardella B,Carlos Oestreicher C,Eveline Gac E,Homero Mosso G,Lorena Soto M,Julia Foradori C,Arnaldo Claverie R,Ximena Ahuad N,Jessica Montero L,Joaquín |
| author_sort |
Cortés P,Paola |
| title |
Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| title_short |
Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| title_full |
Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| title_fullStr |
Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| title_full_unstemmed |
Exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| title_sort |
exceso de mineralocorticoides en hipertensos esenciales: enfoque clínico-diagnóstico |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2000 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900001 |
| work_keys_str_mv |
AT cortesppaola excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT fardellabcarlos excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT oestreicherceveline excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT gacehomero excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT mossoglorena excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT sotomjulia excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT foradoricarnaldo excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT claverierximena excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT ahuadnjessica excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico AT monteroljoaquin excesodemineralocorticoidesenhipertensosesencialesenfoqueclinicodiagnostico |
| _version_ |
1718435934035247104 |