Malformaciones congénitas en los hijos de madres diabéticas

The offspring of diabetic mothers have a 10 times higher frequency of congenital malformations and 5 times higher frequency of spontaneous abortions. Since the discovery of insulin, the prognosis of pregnancies has improved, both for the mother and the offspring. However, the prevalence of congenita...

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Autores principales:	Nazer H,Julio, Ramírez F,Rodrigo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Abnormalities Diabetes, gestational Diabetes mellitus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900014
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spelling	oai:scielo:S0034-988720000009000142005-11-15Malformaciones congénitas en los hijos de madres diabéticasNazer H,JulioRamírez F,Rodrigo Abnormalities Diabetes, gestational Diabetes mellitus The offspring of diabetic mothers have a 10 times higher frequency of congenital malformations and 5 times higher frequency of spontaneous abortions. Since the discovery of insulin, the prognosis of pregnancies has improved, both for the mother and the offspring. However, the prevalence of congenital malformations at birth has not decreased significantly. The embriological process that leads to anomalies in the offspring of diabetic mothers probably occurs between 6 and 8 weeks of gestation. According to animal experiments, hyperglycemia, ketones and free radicals may be involved in the genesis of malfomations, but different strains of rats respond differently to these potential teratogenic agents. Possibly, a higher genetic susceptibility towards congenital malformations also plays a role in diabetic women. Therefore, although the intimate mechanism producing malformations in the offspring of diabetic women is not known, several strategies to decrease the prevalence of malformations in these women, such as the use of antioxidants, are being testedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.9 20002000-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900014es10.4067/S0034-98872000000900014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Abnormalities Diabetes, gestational Diabetes mellitus
spellingShingle	Abnormalities Diabetes, gestational Diabetes mellitus Nazer H,Julio Ramírez F,Rodrigo Malformaciones congénitas en los hijos de madres diabéticas
description	The offspring of diabetic mothers have a 10 times higher frequency of congenital malformations and 5 times higher frequency of spontaneous abortions. Since the discovery of insulin, the prognosis of pregnancies has improved, both for the mother and the offspring. However, the prevalence of congenital malformations at birth has not decreased significantly. The embriological process that leads to anomalies in the offspring of diabetic mothers probably occurs between 6 and 8 weeks of gestation. According to animal experiments, hyperglycemia, ketones and free radicals may be involved in the genesis of malfomations, but different strains of rats respond differently to these potential teratogenic agents. Possibly, a higher genetic susceptibility towards congenital malformations also plays a role in diabetic women. Therefore, although the intimate mechanism producing malformations in the offspring of diabetic women is not known, several strategies to decrease the prevalence of malformations in these women, such as the use of antioxidants, are being tested
author	Nazer H,Julio Ramírez F,Rodrigo
author_facet	Nazer H,Julio Ramírez F,Rodrigo
author_sort	Nazer H,Julio
title	Malformaciones congénitas en los hijos de madres diabéticas
title_short	Malformaciones congénitas en los hijos de madres diabéticas
title_full	Malformaciones congénitas en los hijos de madres diabéticas
title_fullStr	Malformaciones congénitas en los hijos de madres diabéticas
title_full_unstemmed	Malformaciones congénitas en los hijos de madres diabéticas
title_sort	malformaciones congénitas en los hijos de madres diabéticas
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000900014
work_keys_str_mv	AT nazerhjulio malformacionescongenitasenloshijosdemadresdiabeticas AT ramirezfrodrigo malformacionescongenitasenloshijosdemadresdiabeticas
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Malformaciones congénitas en los hijos de madres diabéticas

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