Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos

Background: In patients with type 2 diabetes, the presence of microalbuminuria, reflecting a widespread vascular damage, can be a marker of nephropathy, retinophaty and cardiovascular diseases. Aim: To study the relationship between microalbuminuria and the frequency, severity and outcome of retinop...

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Autores principales:	Durruty A,Pilar, Carpentier G,Cristián, Krause I,Paulina, García de los Ríos A,Manuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Diabetes mellitus, non-insulin-dependent Diabetic angiopathies Diabetic ne-phropathies Diabetic retinopathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000002
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spelling	oai:scielo:S0034-988720000010000022001-01-29Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricosDurruty A,PilarCarpentier G,CristiánKrause I,PaulinaGarcía de los Ríos A,Manuel Diabetes mellitus, non-insulin-dependent Diabetic angiopathies Diabetic ne-phropathies Diabetic retinopathy Background: In patients with type 2 diabetes, the presence of microalbuminuria, reflecting a widespread vascular damage, can be a marker of nephropathy, retinophaty and cardiovascular diseases. Aim: To study the relationship between microalbuminuria and the frequency, severity and outcome of retinopathy in patients with type 2 diabetes mellitus. Patients and methods: One hundred patients with type 2 diabetes were subjected to a clinical examination, serial monitoring of blood pressure and quarterly measurement of microalbuminuria by RIA. Annually, a fundoscopy, a color photography of the posterior pole and retinal angiofluorescence were performed. Retinophaty was classified as basal (mild to moderate), preproliferative and proliferative. Sixty four normoalbuminuric patients (urinary albumin of less than 30 mg/24 h) were included in group 1 and 36 patients with a urinary albumin over 30 mg/24 h in group 2. Fifty seven patients with normal blood pressure were randomly treated with enalapril or placebo and those with hypertension received enalapril or acebutolol to normalize blood pressure. Results: Sixty one percent of group 1 patients and 41% of group 2 patients has retinopathy (p < 0.05). The retinal lesions were proliferative in 41% of group 2 patients and in 8% of group 1 patient (p < 0.05). Retinopathy was present in 67% of hypertensive patients of group 2 and in 41% of hypertensive patients of group 1. An unfavorable evolution of retinopathy was observed in 22% of group 2 patients and in 5% of group 1 patient (p < 0.05). Conclusions: In type 2 diabetic patients, the presence of microalbuminuria is a prediction of a higher frequency, severity and dismal evolution of diabetic retinopathy (Rev Méd Chile 2000; 128: 1085-92).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.10 20002000-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000002es10.4067/S0034-98872000001000002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus, non-insulin-dependent Diabetic angiopathies Diabetic ne-phropathies Diabetic retinopathy
spellingShingle	Diabetes mellitus, non-insulin-dependent Diabetic angiopathies Diabetic ne-phropathies Diabetic retinopathy Durruty A,Pilar Carpentier G,Cristián Krause I,Paulina García de los Ríos A,Manuel Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
description	Background: In patients with type 2 diabetes, the presence of microalbuminuria, reflecting a widespread vascular damage, can be a marker of nephropathy, retinophaty and cardiovascular diseases. Aim: To study the relationship between microalbuminuria and the frequency, severity and outcome of retinopathy in patients with type 2 diabetes mellitus. Patients and methods: One hundred patients with type 2 diabetes were subjected to a clinical examination, serial monitoring of blood pressure and quarterly measurement of microalbuminuria by RIA. Annually, a fundoscopy, a color photography of the posterior pole and retinal angiofluorescence were performed. Retinophaty was classified as basal (mild to moderate), preproliferative and proliferative. Sixty four normoalbuminuric patients (urinary albumin of less than 30 mg/24 h) were included in group 1 and 36 patients with a urinary albumin over 30 mg/24 h in group 2. Fifty seven patients with normal blood pressure were randomly treated with enalapril or placebo and those with hypertension received enalapril or acebutolol to normalize blood pressure. Results: Sixty one percent of group 1 patients and 41% of group 2 patients has retinopathy (p < 0.05). The retinal lesions were proliferative in 41% of group 2 patients and in 8% of group 1 patient (p < 0.05). Retinopathy was present in 67% of hypertensive patients of group 2 and in 41% of hypertensive patients of group 1. An unfavorable evolution of retinopathy was observed in 22% of group 2 patients and in 5% of group 1 patient (p < 0.05). Conclusions: In type 2 diabetic patients, the presence of microalbuminuria is a prediction of a higher frequency, severity and dismal evolution of diabetic retinopathy (Rev Méd Chile 2000; 128: 1085-92).
author	Durruty A,Pilar Carpentier G,Cristián Krause I,Paulina García de los Ríos A,Manuel
author_facet	Durruty A,Pilar Carpentier G,Cristián Krause I,Paulina García de los Ríos A,Manuel
author_sort	Durruty A,Pilar
title	Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
title_short	Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
title_full	Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
title_fullStr	Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
title_full_unstemmed	Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
title_sort	evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000002
work_keys_str_mv	AT durrutyapilar evaluaciondelcompromisoretinalendiabeticostipo2microalbuminuricos AT carpentiergcristian evaluaciondelcompromisoretinalendiabeticostipo2microalbuminuricos AT krauseipaulina evaluaciondelcompromisoretinalendiabeticostipo2microalbuminuricos AT garciadelosriosamanuel evaluaciondelcompromisoretinalendiabeticostipo2microalbuminuricos
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Evaluación del compromiso retinal en diabéticos tipo 2 microalbuminúricos

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