Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica

Background: Measurement of changes in serum antibodies is an excellent predictor of Helicobacter pylori eradication after antibiotic treatment. Aim: To measure the changes in serum antibody titers to Helicobacter pylori, before and after treatment. Material and methods: IgG antibodies to H. pylori w...

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Autores principales:	Figueroa G,Guillermo, Troncoso H,Miriam, Toledo B,M. Soledad, Acuña M,Raúl
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Antibiotics ELISA Helicobacter pylori Peptic ulcer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000007
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spelling	oai:scielo:S0034-988720000010000072001-01-29Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera pépticaFigueroa G,GuillermoTroncoso H,MiriamToledo B,M. SoledadAcuña M,Raúl Antibiotics ELISA Helicobacter pylori Peptic ulcer Background: Measurement of changes in serum antibodies is an excellent predictor of Helicobacter pylori eradication after antibiotic treatment. Aim: To measure the changes in serum antibody titers to Helicobacter pylori, before and after treatment. Material and methods: IgG antibodies to H. pylori were prospectively evaluated in 107 duodenal ulcer patients treated either with antibiotics (amoxicillin, metronidazole and bismuth subsalicylate) plus omeprazole or omeprazole alone. IgG antibody levels were determined using an "in house" ELISA in sera from 49 eradicated patients that received quadruple therapy and 58 non-eradicated patients (12 in whom antibiotic therapy failed and 46 that received omeprazole alone). Endoscopy, urease test, microscopy, and culture of gastric biopsies confirmed H. pylori eradication. Results: Patients in whom H. pylori was eradicated, showed a maintained drop in serum antibody titers that ranged from 15%, 62%, 74% to 76% at 28 days, 4, 8 and 12 months respectively. Such reduction was not observed in patients treated with omeprazole. Patients, in whom quadruple therapy failed to eradicate H. pylori, showed a discrete and transient decrease in antibody titers. By the fourth month, patients in whom eradication with quadruple therapy was not achieved, irrespective of whether they received quadruple therapy or omeprazole alone. Conclusions: A 45% decrease in IgG titer after 4 months is indicative of therapeutic success in H. pylori eradication. Therefore, serology may be useful to monitor the outcome of antibiotic therapy (Rev Méd Chile 2000; 128: 1119-26)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.10 20002000-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000007es10.4067/S0034-98872000001000007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibiotics ELISA Helicobacter pylori Peptic ulcer
spellingShingle	Antibiotics ELISA Helicobacter pylori Peptic ulcer Figueroa G,Guillermo Troncoso H,Miriam Toledo B,M. Soledad Acuña M,Raúl Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
description	Background: Measurement of changes in serum antibodies is an excellent predictor of Helicobacter pylori eradication after antibiotic treatment. Aim: To measure the changes in serum antibody titers to Helicobacter pylori, before and after treatment. Material and methods: IgG antibodies to H. pylori were prospectively evaluated in 107 duodenal ulcer patients treated either with antibiotics (amoxicillin, metronidazole and bismuth subsalicylate) plus omeprazole or omeprazole alone. IgG antibody levels were determined using an "in house" ELISA in sera from 49 eradicated patients that received quadruple therapy and 58 non-eradicated patients (12 in whom antibiotic therapy failed and 46 that received omeprazole alone). Endoscopy, urease test, microscopy, and culture of gastric biopsies confirmed H. pylori eradication. Results: Patients in whom H. pylori was eradicated, showed a maintained drop in serum antibody titers that ranged from 15%, 62%, 74% to 76% at 28 days, 4, 8 and 12 months respectively. Such reduction was not observed in patients treated with omeprazole. Patients, in whom quadruple therapy failed to eradicate H. pylori, showed a discrete and transient decrease in antibody titers. By the fourth month, patients in whom eradication with quadruple therapy was not achieved, irrespective of whether they received quadruple therapy or omeprazole alone. Conclusions: A 45% decrease in IgG titer after 4 months is indicative of therapeutic success in H. pylori eradication. Therefore, serology may be useful to monitor the outcome of antibiotic therapy (Rev Méd Chile 2000; 128: 1119-26)
author	Figueroa G,Guillermo Troncoso H,Miriam Toledo B,M. Soledad Acuña M,Raúl
author_facet	Figueroa G,Guillermo Troncoso H,Miriam Toledo B,M. Soledad Acuña M,Raúl
author_sort	Figueroa G,Guillermo
title	Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
title_short	Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
title_full	Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
title_fullStr	Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
title_full_unstemmed	Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica
title_sort	aplicación de la serología para confirmar la erradicación de helicobacter pylori en pacientes con úlcera péptica
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000007
work_keys_str_mv	AT figueroagguillermo aplicaciondelaserologiaparaconfirmarlaerradicaciondehelicobacterpylorienpacientesconulcerapeptica AT troncosohmiriam aplicaciondelaserologiaparaconfirmarlaerradicaciondehelicobacterpylorienpacientesconulcerapeptica AT toledobmsoledad aplicaciondelaserologiaparaconfirmarlaerradicaciondehelicobacterpylorienpacientesconulcerapeptica AT acunamraul aplicaciondelaserologiaparaconfirmarlaerradicaciondehelicobacterpylorienpacientesconulcerapeptica
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Aplicación de la serología para confirmar la erradicación de Helicobacter pylori en pacientes con úlcera péptica

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