Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas

Cells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show...

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Autor principal:	González C,Jorge
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Leishmania Phosphorylation Phosphorylase kinase Phosphorylase phosphatase Protozoan infections Trypanosoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000012
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spelling	oai:scielo:S0034-988720000010000122001-01-29Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneasGonzález C,Jorge Leishmania Phosphorylation Phosphorylase kinase Phosphorylase phosphatase Protozoan infections Trypanosoma Cells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show that phosphatases and kinases are also involved in the molecular basis of immune response and in diseases such as diabetes obesity and Alzheimer. In protozoan parasites like Trypanosoma and Leishmania, several kinases and phosphatases have been identified, many of them have been cloned but in several cases their biological role remains undetermined. In this review, the state-of-the art is summarized and the role of phosphatases and kinases in biological phenomena such as remodeling, invasion and pathogenic capacity of protozoan parasites is described. The real chance to use these components of signal transduction pathways as target for chemotherapeutic intervention is also discussed (Rev Méd Chile 2000; 128: 1150-60).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.10 20002000-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000012es10.4067/S0034-98872000001000012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Leishmania Phosphorylation Phosphorylase kinase Phosphorylase phosphatase Protozoan infections Trypanosoma
spellingShingle	Leishmania Phosphorylation Phosphorylase kinase Phosphorylase phosphatase Protozoan infections Trypanosoma González C,Jorge Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
description	Cells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show that phosphatases and kinases are also involved in the molecular basis of immune response and in diseases such as diabetes obesity and Alzheimer. In protozoan parasites like Trypanosoma and Leishmania, several kinases and phosphatases have been identified, many of them have been cloned but in several cases their biological role remains undetermined. In this review, the state-of-the art is summarized and the role of phosphatases and kinases in biological phenomena such as remodeling, invasion and pathogenic capacity of protozoan parasites is described. The real chance to use these components of signal transduction pathways as target for chemotherapeutic intervention is also discussed (Rev Méd Chile 2000; 128: 1150-60).
author	González C,Jorge
author_facet	González C,Jorge
author_sort	González C,Jorge
title	Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
title_short	Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
title_full	Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
title_fullStr	Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
title_full_unstemmed	Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
title_sort	fosforilación en células eucarióticas: papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001000012
work_keys_str_mv	AT gonzalezcjorge fosforilacionencelulaseucarioticaspapeldefosfatasasyquinasasenlabiologiapatogeniaycontroldeprotozoosistisularesysanguineas
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Fosforilación en células eucarióticas: Papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas

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