Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998

Background: The incidence of acute myeloid leukemia is 3 cases per 100.000 inhabitants/year and its five years event free survival is 15 to 20%. Since the incorporation of trans retinoic acid, event free survival of M3 acute myeloid leukemia is 80%. Aim: To report the results of acute myeloid leukem...

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Autores principales:	Puga L,Barbara, Cabrera C,María Elena, Undurraga S,María Soledad, Etcheverry B,Raúl, Vacarezza Y,Ricardo, Ducach G,Germán, Toledo G,Humberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Antineoplastic agents combined Chemotherapy adjuvant Leukemia myeloid promyelocytic acute
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100002
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spelling	oai:scielo:S0034-988720000011000022001-01-29Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998Puga L,BarbaraCabrera C,María ElenaUndurraga S,María SoledadEtcheverry B,RaúlVacarezza Y,RicardoDucach G,GermánToledo G,Humberto Antineoplastic agents combined Chemotherapy adjuvant Leukemia myeloid Leukemia promyelocytic acute Background: The incidence of acute myeloid leukemia is 3 cases per 100.000 inhabitants/year and its five years event free survival is 15 to 20%. Since the incorporation of trans retinoic acid, event free survival of M3 acute myeloid leukemia is 80%. Aim: To report the results of acute myeloid leukemia treatment at the Hospital del Salvador, between 1990 and 1998. Patients and methods: The medical records of 117 patients (66 female, mean age 48.2 years), treated between 1990 and 1998 using PANDA protocol, were retrospectively reviewed. Immunophenotyping was done in 69 patients and cytogenetic studies were done in 65. Results: Sixteen percent of patients had M3 acute myeloid leukemia. The most frequent phenotype was the association of DR, CD34 plus a panmyeloid marker. DR and CD34 were negative in seven of nine patients with M3 acute myeloid leukemia. Cariotype was abnormal in 78% of patients. Complete remission was achieved in 65% of cases with a 13% of failures. Early mortality was 21.3% and decreased to 6.1% in the last three years. Infections and coagulation disorders were the main causes of death. Mean survival was 10.5 months. Five years event free survival was 11%. In M3 acute myeloid leukemia, the figure is 50%. Conclusions: Treatment results are less effective than protocols that consider more aggressive chemotherapeutic protocols or bone marrow transplantation. The reduction in early mortality is due to a better management of febrile neutropenia (Rev Méd Chile 2000; 128: 1191-98)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.11 20002000-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100002es10.4067/S0034-98872000001100002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antineoplastic agents combined Chemotherapy adjuvant Leukemia myeloid Leukemia promyelocytic acute
spellingShingle	Antineoplastic agents combined Chemotherapy adjuvant Leukemia myeloid Leukemia promyelocytic acute Puga L,Barbara Cabrera C,María Elena Undurraga S,María Soledad Etcheverry B,Raúl Vacarezza Y,Ricardo Ducach G,Germán Toledo G,Humberto Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
description	Background: The incidence of acute myeloid leukemia is 3 cases per 100.000 inhabitants/year and its five years event free survival is 15 to 20%. Since the incorporation of trans retinoic acid, event free survival of M3 acute myeloid leukemia is 80%. Aim: To report the results of acute myeloid leukemia treatment at the Hospital del Salvador, between 1990 and 1998. Patients and methods: The medical records of 117 patients (66 female, mean age 48.2 years), treated between 1990 and 1998 using PANDA protocol, were retrospectively reviewed. Immunophenotyping was done in 69 patients and cytogenetic studies were done in 65. Results: Sixteen percent of patients had M3 acute myeloid leukemia. The most frequent phenotype was the association of DR, CD34 plus a panmyeloid marker. DR and CD34 were negative in seven of nine patients with M3 acute myeloid leukemia. Cariotype was abnormal in 78% of patients. Complete remission was achieved in 65% of cases with a 13% of failures. Early mortality was 21.3% and decreased to 6.1% in the last three years. Infections and coagulation disorders were the main causes of death. Mean survival was 10.5 months. Five years event free survival was 11%. In M3 acute myeloid leukemia, the figure is 50%. Conclusions: Treatment results are less effective than protocols that consider more aggressive chemotherapeutic protocols or bone marrow transplantation. The reduction in early mortality is due to a better management of febrile neutropenia (Rev Méd Chile 2000; 128: 1191-98)
author	Puga L,Barbara Cabrera C,María Elena Undurraga S,María Soledad Etcheverry B,Raúl Vacarezza Y,Ricardo Ducach G,Germán Toledo G,Humberto
author_facet	Puga L,Barbara Cabrera C,María Elena Undurraga S,María Soledad Etcheverry B,Raúl Vacarezza Y,Ricardo Ducach G,Germán Toledo G,Humberto
author_sort	Puga L,Barbara
title	Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
title_short	Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
title_full	Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
title_fullStr	Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
title_full_unstemmed	Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998
title_sort	leucemia mieloide aguda del adulto: resultados del protocolo nacional de drogas antineoplásica. hospital del salvador 1990-1998
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100002
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Leucemia mieloide aguda del adulto: Resultados del Protocolo Nacional de Drogas Antineoplásica. Hospital del Salvador 1990-1998

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