Rechazo humoral en trasplante cardíaco: Comunicación de dos casos

Heart transplantation is a therapeutic alternative for selected patients with refractory heart failure. Acute allograft rejection is one of the main causes of early death after transplantation. The cellular rejection is characterized by cellular infiltrates with or without miocyte necrosis. However,...

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Autores principales:	Castro G,Pablo, Arriagada S,Germán, Moreno S,Mauricio, Morán V,Sergio, Becker R,Pedro, Zalaquett S,Ricardo, Godoy J,Iván, Córdova A,Samuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Azathioprine Heart transplantation Methylprednisolone Transplantation isogeneic Transplant rejection
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100009
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spelling	oai:scielo:S0034-988720000011000092001-01-29Rechazo humoral en trasplante cardíaco: Comunicación de dos casosCastro G,PabloArriagada S,GermánMoreno S,MauricioMorán V,SergioBecker R,PedroZalaquett S,RicardoGodoy J,IvánCórdova A,Samuel Azathioprine Heart transplantation Methylprednisolone Transplantation isogeneic Transplant rejection Heart transplantation is a therapeutic alternative for selected patients with refractory heart failure. Acute allograft rejection is one of the main causes of early death after transplantation. The cellular rejection is characterized by cellular infiltrates with or without miocyte necrosis. However, some patients develop left ventricular dysfunction due to rejection without evidence of cellular infiltration. In these patients, the rejection is mediated by antibodies and complement. Humoral rejection is a relative rare but potentially fatal form of acute allograft rejection. We report two patients with left ventricular dysfunction secondary to humoral rejection, shortly after cardiac transplantation. Both patients were treated with methylprednisolone, and azathioprine was substituted by cyclophosphamide. One patient underwent plasmapheresis. The clinical outcome was satisfactory and the left ventricular function returned to normal in both cases. The diagnostic and therapeutic strategies for the management of humoral rejection are reviewed (Rev Méd Chile 2000; 128: 1245-49)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.11 20002000-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100009es10.4067/S0034-98872000001100009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Azathioprine Heart transplantation Methylprednisolone Transplantation isogeneic Transplant rejection
spellingShingle	Azathioprine Heart transplantation Methylprednisolone Transplantation isogeneic Transplant rejection Castro G,Pablo Arriagada S,Germán Moreno S,Mauricio Morán V,Sergio Becker R,Pedro Zalaquett S,Ricardo Godoy J,Iván Córdova A,Samuel Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
description	Heart transplantation is a therapeutic alternative for selected patients with refractory heart failure. Acute allograft rejection is one of the main causes of early death after transplantation. The cellular rejection is characterized by cellular infiltrates with or without miocyte necrosis. However, some patients develop left ventricular dysfunction due to rejection without evidence of cellular infiltration. In these patients, the rejection is mediated by antibodies and complement. Humoral rejection is a relative rare but potentially fatal form of acute allograft rejection. We report two patients with left ventricular dysfunction secondary to humoral rejection, shortly after cardiac transplantation. Both patients were treated with methylprednisolone, and azathioprine was substituted by cyclophosphamide. One patient underwent plasmapheresis. The clinical outcome was satisfactory and the left ventricular function returned to normal in both cases. The diagnostic and therapeutic strategies for the management of humoral rejection are reviewed (Rev Méd Chile 2000; 128: 1245-49)
author	Castro G,Pablo Arriagada S,Germán Moreno S,Mauricio Morán V,Sergio Becker R,Pedro Zalaquett S,Ricardo Godoy J,Iván Córdova A,Samuel
author_facet	Castro G,Pablo Arriagada S,Germán Moreno S,Mauricio Morán V,Sergio Becker R,Pedro Zalaquett S,Ricardo Godoy J,Iván Córdova A,Samuel
author_sort	Castro G,Pablo
title	Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
title_short	Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
title_full	Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
title_fullStr	Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
title_full_unstemmed	Rechazo humoral en trasplante cardíaco: Comunicación de dos casos
title_sort	rechazo humoral en trasplante cardíaco: comunicación de dos casos
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100009
work_keys_str_mv	AT castrogpablo rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT arriagadasgerman rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT morenosmauricio rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT moranvsergio rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT beckerrpedro rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT zalaquettsricardo rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT godoyjivan rechazohumoralentrasplantecardiacocomunicaciondedoscasos AT cordovaasamuel rechazohumoralentrasplantecardiacocomunicaciondedoscasos
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Rechazo humoral en trasplante cardíaco: Comunicación de dos casos

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