Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple

A Multiple Myeloma (MM), IgG-lambda stage III-A was diagnosed in a 41-year-old-man. After VAD cycles IgG decreased from 7.5 to 2.4 g/dL. were mobilized with cyclophosphamide and 10 µg/Kg G-CSF. Three days after the collection of peripheral stem cell, the patient had fever, nausea, vomiting, liquid s...

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Autores principales:	Conte L,Guillermo, Conte S,Francisco J, Ojeda F,José M, Araos H,Daniel, Poniachik T,Jaime, Murray C,Guillermo, Flores P,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Multiple myeloma Purpura Schönlein-Henoch Vasculitis hypersensitivity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100011
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spelling	oai:scielo:S0034-988720000011000112001-01-29Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltipleConte L,GuillermoConte S,Francisco JOjeda F,José MAraos H,DanielPoniachik T,JaimeMurray C,GuillermoFlores P,Claudio Multiple myeloma Purpura Schönlein-Henoch Vasculitis hypersensitivity A Multiple Myeloma (MM), IgG-lambda stage III-A was diagnosed in a 41-year-old-man. After VAD cycles IgG decreased from 7.5 to 2.4 g/dL. were mobilized with cyclophosphamide and 10 µg/Kg G-CSF. Three days after the collection of peripheral stem cell, the patient had fever, nausea, vomiting, liquid stools, shoulder and knee arthralgia and dehydration. Upper GI endoscopy showed esophageal candidiasis and ulcerative necrotic lesions both in stomach and duodenum; the biopsy confirmed necrosis. Simultaneously, the appearance of purpura with maculopapular lesions of diverse sizes appeared in the feet progressing to the limbs and trunk. Hematuria and proteinuria were also observed. Skin biopsy showed leukocytoclastic vasculitis. Renal biopsy showed focal and segmental glomerulonephritis. Serum ANCA, cryoglobulins, anti-HCV and RF were negative, and serum monoclonal IgG was 1290 mg/dL. Daily treatment with iv methylprednisolone pulses for 3 days improved skin lesions and digestive involvement. Macroscopic hematuria and proteinuria improved after two months of steroid treatment (Rev Méd Chile 2000; 128: 1255-60)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.11 20002000-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100011es10.4067/S0034-98872000001100011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Multiple myeloma Purpura Schönlein-Henoch Vasculitis hypersensitivity
spellingShingle	Multiple myeloma Purpura Schönlein-Henoch Vasculitis hypersensitivity Conte L,Guillermo Conte S,Francisco J Ojeda F,José M Araos H,Daniel Poniachik T,Jaime Murray C,Guillermo Flores P,Claudio Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
description	A Multiple Myeloma (MM), IgG-lambda stage III-A was diagnosed in a 41-year-old-man. After VAD cycles IgG decreased from 7.5 to 2.4 g/dL. were mobilized with cyclophosphamide and 10 µg/Kg G-CSF. Three days after the collection of peripheral stem cell, the patient had fever, nausea, vomiting, liquid stools, shoulder and knee arthralgia and dehydration. Upper GI endoscopy showed esophageal candidiasis and ulcerative necrotic lesions both in stomach and duodenum; the biopsy confirmed necrosis. Simultaneously, the appearance of purpura with maculopapular lesions of diverse sizes appeared in the feet progressing to the limbs and trunk. Hematuria and proteinuria were also observed. Skin biopsy showed leukocytoclastic vasculitis. Renal biopsy showed focal and segmental glomerulonephritis. Serum ANCA, cryoglobulins, anti-HCV and RF were negative, and serum monoclonal IgG was 1290 mg/dL. Daily treatment with iv methylprednisolone pulses for 3 days improved skin lesions and digestive involvement. Macroscopic hematuria and proteinuria improved after two months of steroid treatment (Rev Méd Chile 2000; 128: 1255-60)
author	Conte L,Guillermo Conte S,Francisco J Ojeda F,José M Araos H,Daniel Poniachik T,Jaime Murray C,Guillermo Flores P,Claudio
author_facet	Conte L,Guillermo Conte S,Francisco J Ojeda F,José M Araos H,Daniel Poniachik T,Jaime Murray C,Guillermo Flores P,Claudio
author_sort	Conte L,Guillermo
title	Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
title_short	Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
title_full	Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
title_fullStr	Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
title_full_unstemmed	Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple
title_sort	púrpura de schönlein-henoch grave en un paciente con mieloma múltiple
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100011
work_keys_str_mv	AT contelguillermo purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT contesfranciscoj purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT ojedafjosem purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT araoshdaniel purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT poniachiktjaime purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT murraycguillermo purpuradeschonleinhenochgraveenunpacienteconmielomamultiple AT florespclaudio purpuradeschonleinhenochgraveenunpacienteconmielomamultiple
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Púrpura de Schönlein-Henoch grave en un paciente con mieloma múltiple

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