Gen supresor de tumores p53 en neoplasias digestivas

Malignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are spe...

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Autores principales:	Roa S,Juan C, Roa E,Iván, Araya O,Juan C, Villaseca H,Miguel A, Melo A,Angélica, Burgos S,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Genes, p53 Genetic markers Genetic predisposition to disease Digestive system neoplasm
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100013
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spelling	oai:scielo:S0034-988720000011000132001-01-29Gen supresor de tumores p53 en neoplasias digestivasRoa S,Juan CRoa E,IvánAraya O,Juan CVillaseca H,Miguel AMelo A,AngélicaBurgos S,Luis Genes, p53 Genetic markers Genetic predisposition to disease Digestive system neoplasm Malignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene (Rev Méd Chile 2000; 128: 1269-78)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.11 20002000-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100013es10.4067/S0034-98872000001100013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Genes, p53 Genetic markers Genetic predisposition to disease Digestive system neoplasm
spellingShingle	Genes, p53 Genetic markers Genetic predisposition to disease Digestive system neoplasm Roa S,Juan C Roa E,Iván Araya O,Juan C Villaseca H,Miguel A Melo A,Angélica Burgos S,Luis Gen supresor de tumores p53 en neoplasias digestivas
description	Malignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene (Rev Méd Chile 2000; 128: 1269-78)
author	Roa S,Juan C Roa E,Iván Araya O,Juan C Villaseca H,Miguel A Melo A,Angélica Burgos S,Luis
author_facet	Roa S,Juan C Roa E,Iván Araya O,Juan C Villaseca H,Miguel A Melo A,Angélica Burgos S,Luis
author_sort	Roa S,Juan C
title	Gen supresor de tumores p53 en neoplasias digestivas
title_short	Gen supresor de tumores p53 en neoplasias digestivas
title_full	Gen supresor de tumores p53 en neoplasias digestivas
title_fullStr	Gen supresor de tumores p53 en neoplasias digestivas
title_full_unstemmed	Gen supresor de tumores p53 en neoplasias digestivas
title_sort	gen supresor de tumores p53 en neoplasias digestivas
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100013
work_keys_str_mv	AT roasjuanc gensupresordetumoresp53enneoplasiasdigestivas AT roaeivan gensupresordetumoresp53enneoplasiasdigestivas AT arayaojuanc gensupresordetumoresp53enneoplasiasdigestivas AT villasecahmiguela gensupresordetumoresp53enneoplasiasdigestivas AT meloaangelica gensupresordetumoresp53enneoplasiasdigestivas AT burgossluis gensupresordetumoresp53enneoplasiasdigestivas
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Gen supresor de tumores p53 en neoplasias digestivas

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