Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios

Background: Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. Aim: To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. Material and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Prado J,Valeria, Giangrieco O,Marcela, Durán T,Claudia, Ojeda S,Alicia, Flaskamp von F,Renate
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Anti-Infective Agents Quinolones Respiratory Tract Infections
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872000001200003
record_format	dspace
spelling	oai:scielo:S0034-988720000012000032001-02-08Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratoriosPrado J,ValeriaGiangrieco O,MarcelaDurán T,ClaudiaOjeda S,AliciaFlaskamp von F,Renate Anti-Infective Agents Quinolones Respiratory Tract Infections Background: Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. Aim: To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. Material and methods: Forty five strains of S pneumoniae, 44 strains of H influenzae, 21 strains of M catarrhalis, 10 strains of methicillin susceptible S aureus and 20 strains of methicillin resistant S aureus were studied. All were isolated from community acquired respiratory infections during 1999. Minimal inhibitory concentrations of moxifloxacin, amoxicilin, amoxicilin/clavulanic acid, clarithromycin, azithromycin, ciprofloxacin and levofloxacin were determined using the Etest method. Betalactamase production by H influenzae and M catarrhalis was also studied. Results: S pneumoniae strains were 100% susceptible to quinolones and cotrimoxazole, 2% were resistant to macrolides, 11% were resistant to amoxicilin/clavulanic acid and 47% were resistant to cefuroxime. H influenzae was 100% susceptible to quinolones, azithromycin and amoxicilin/clavulanic acid. There was a 53% resistance to cotrimoxazole, 21% to amoxicilin, 9% to clarithromycin and 7% to cefuroxime. M catarrhalis was 100% susceptible to quinolones and 100% resistant to amoxicilin, 5% resistant to macrolides, 14% resistant to amoxicilin/clavulanic acid, 20% to cefuroxime and 30% to cotrimoxazole. Methicilline susceptible S aureus was susceptible to all antimicrobials and methicillin resistant S aureus was resistant to all. Conclusions: Moxifloxacin and the new respiratory quinolones can be useful in the treatment of respiratory infections (Rev Méd Chile 2000; 128: 1319-26).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.12 20002000-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200003es10.4067/S0034-98872000001200003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anti-Infective Agents Quinolones Respiratory Tract Infections
spellingShingle	Anti-Infective Agents Quinolones Respiratory Tract Infections Prado J,Valeria Giangrieco O,Marcela Durán T,Claudia Ojeda S,Alicia Flaskamp von F,Renate Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
description	Background: Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. Aim: To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. Material and methods: Forty five strains of S pneumoniae, 44 strains of H influenzae, 21 strains of M catarrhalis, 10 strains of methicillin susceptible S aureus and 20 strains of methicillin resistant S aureus were studied. All were isolated from community acquired respiratory infections during 1999. Minimal inhibitory concentrations of moxifloxacin, amoxicilin, amoxicilin/clavulanic acid, clarithromycin, azithromycin, ciprofloxacin and levofloxacin were determined using the Etest method. Betalactamase production by H influenzae and M catarrhalis was also studied. Results: S pneumoniae strains were 100% susceptible to quinolones and cotrimoxazole, 2% were resistant to macrolides, 11% were resistant to amoxicilin/clavulanic acid and 47% were resistant to cefuroxime. H influenzae was 100% susceptible to quinolones, azithromycin and amoxicilin/clavulanic acid. There was a 53% resistance to cotrimoxazole, 21% to amoxicilin, 9% to clarithromycin and 7% to cefuroxime. M catarrhalis was 100% susceptible to quinolones and 100% resistant to amoxicilin, 5% resistant to macrolides, 14% resistant to amoxicilin/clavulanic acid, 20% to cefuroxime and 30% to cotrimoxazole. Methicilline susceptible S aureus was susceptible to all antimicrobials and methicillin resistant S aureus was resistant to all. Conclusions: Moxifloxacin and the new respiratory quinolones can be useful in the treatment of respiratory infections (Rev Méd Chile 2000; 128: 1319-26).
author	Prado J,Valeria Giangrieco O,Marcela Durán T,Claudia Ojeda S,Alicia Flaskamp von F,Renate
author_facet	Prado J,Valeria Giangrieco O,Marcela Durán T,Claudia Ojeda S,Alicia Flaskamp von F,Renate
author_sort	Prado J,Valeria
title	Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
title_short	Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
title_full	Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
title_fullStr	Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
title_full_unstemmed	Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
title_sort	actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200003
work_keys_str_mv	AT pradojvaleria actividadcomparativainvitrodemoxifloxacinayotrosantimicrobianosfrenteapatogenosrespiratorios AT giangriecoomarcela actividadcomparativainvitrodemoxifloxacinayotrosantimicrobianosfrenteapatogenosrespiratorios AT durantclaudia actividadcomparativainvitrodemoxifloxacinayotrosantimicrobianosfrenteapatogenosrespiratorios AT ojedasalicia actividadcomparativainvitrodemoxifloxacinayotrosantimicrobianosfrenteapatogenosrespiratorios AT flaskampvonfrenate actividadcomparativainvitrodemoxifloxacinayotrosantimicrobianosfrenteapatogenosrespiratorios
_version_	1718435947839750144

Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios

Ejemplares similares