Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco

Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco

There are many stages and a large investment of both time and money involved in the process of research and development before a new drug can be prescribed for clinical use. Of the thousands of new molecular entities, only one or two are approved for commercialization, after having endured a traject...

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Autor principal: Marovac,Jacqueline
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2001
Materias:
Drug approval
Drug design
Drug therapy
Medications systems
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000100015
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spelling oai:scielo:S0034-988720010001000152005-11-23Investigación y desarrollo de nuevos medicamentos: de la molécula al fármacoMarovac,Jacqueline Drug approval Drug design Drug therapy Medications systems There are many stages and a large investment of both time and money involved in the process of research and development before a new drug can be prescribed for clinical use. Of the thousands of new molecular entities, only one or two are approved for commercialization, after having endured a trajectory of 12 to 15 years in clinical trials in both animals and humans, demonstrating their therapeutic effectiveness and safety. There are three large administrators of medicines that control the process of new drug registration, the FDA - Food and Drug Administration of the USA being the largest and most well known. This article is based on their model and details the various stages that the molecule must undergo before finally being administered to patients. The future holds many exciting promises for new drug development with the advent of the human genome project and other highly advanced technological methods. However, the main challenge still remains, which is to guarantee the access of basic medicines to the majority of the world’s population that is still without them (Rev Méd Chile 2001; 129: 99-106)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.1 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000100015es10.4067/S0034-98872001000100015
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Drug approval
Drug design
Drug therapy
Medications systems
spellingShingle Drug approval
Drug design
Drug therapy
Medications systems
Marovac,Jacqueline
Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
description There are many stages and a large investment of both time and money involved in the process of research and development before a new drug can be prescribed for clinical use. Of the thousands of new molecular entities, only one or two are approved for commercialization, after having endured a trajectory of 12 to 15 years in clinical trials in both animals and humans, demonstrating their therapeutic effectiveness and safety. There are three large administrators of medicines that control the process of new drug registration, the FDA - Food and Drug Administration of the USA being the largest and most well known. This article is based on their model and details the various stages that the molecule must undergo before finally being administered to patients. The future holds many exciting promises for new drug development with the advent of the human genome project and other highly advanced technological methods. However, the main challenge still remains, which is to guarantee the access of basic medicines to the majority of the world’s population that is still without them (Rev Méd Chile 2001; 129: 99-106)
author Marovac,Jacqueline
author_facet Marovac,Jacqueline
author_sort Marovac,Jacqueline
title Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
title_short Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
title_full Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
title_fullStr Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
title_full_unstemmed Investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
title_sort investigación y desarrollo de nuevos medicamentos: de la molécula al fármaco
publisher Sociedad Médica de Santiago
publishDate 2001
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000100015
work_keys_str_mv AT marovacjacqueline investigacionydesarrollodenuevosmedicamentosdelamoleculaalfarmaco
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