Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes

Background: Staging of colorectal carcinoma has prognostic value and allows to take decisions about adjuvant therapy and follow up. Prognostic factors are not universally accepted and there are different staging classifications. Aim: To assess the prognostic value of clinical and pathological variab...

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Autores principales:	Bannura C,Guillermo, Cumsille G,Miguel A., Contreras P,Jaime, Melo L,Carlos, Barrera E,Alejandro, Reinero C,Macarena, Pardo T,Lorena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Colonic neoplasms Colorectal surgery Rectal neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300001
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spelling	oai:scielo:S0034-988720010003000012001-05-22Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientesBannura C,GuillermoCumsille G,Miguel A.Contreras P,JaimeMelo L,CarlosBarrera E,AlejandroReinero C,MacarenaPardo T,Lorena Colonic neoplasms Colorectal surgery Rectal neoplasms Background: Staging of colorectal carcinoma has prognostic value and allows to take decisions about adjuvant therapy and follow up. Prognostic factors are not universally accepted and there are different staging classifications. Aim: To assess the prognostic value of clinical and pathological variables in 224 patients subjected to a curative resection of a colorectal carcinoma. Patients and methods: A retrospective analysis of 99 men and 125 women, aged 23 to 91 years old subjected to a curative resection of a colorectal carcinoma and followed up for a mean of 72 months. Results: Global survival at 60 months was 72%. Univariate analysis showed that tumor localization, vascular permeation, wall infiltration and number of involved lymph nodes had an influence on survival. A Cox regression model disclosed tumor localization (colon versus rectum), a carcinoembrionic antigen over 30 ng/ml, vascular permeation, presence of 1 to 4 involved lymph nodes, or 5 or more lymph nodes and the presence of an apical lymph node as variables with significant prognostic value. Conclusions: Our series confirms the prognostic importance of lymph node involvement. This parameter is incorporated in Jass, GITSG (both modifications of Dukes classification) and TNM staging scores. (Rev Méd Chile 2001; 129: 237-46).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.3 20012001-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300001es10.4067/S0034-98872001000300001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Colonic neoplasms Colorectal surgery Rectal neoplasms
spellingShingle	Colonic neoplasms Colorectal surgery Rectal neoplasms Bannura C,Guillermo Cumsille G,Miguel A. Contreras P,Jaime Melo L,Carlos Barrera E,Alejandro Reinero C,Macarena Pardo T,Lorena Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
description	Background: Staging of colorectal carcinoma has prognostic value and allows to take decisions about adjuvant therapy and follow up. Prognostic factors are not universally accepted and there are different staging classifications. Aim: To assess the prognostic value of clinical and pathological variables in 224 patients subjected to a curative resection of a colorectal carcinoma. Patients and methods: A retrospective analysis of 99 men and 125 women, aged 23 to 91 years old subjected to a curative resection of a colorectal carcinoma and followed up for a mean of 72 months. Results: Global survival at 60 months was 72%. Univariate analysis showed that tumor localization, vascular permeation, wall infiltration and number of involved lymph nodes had an influence on survival. A Cox regression model disclosed tumor localization (colon versus rectum), a carcinoembrionic antigen over 30 ng/ml, vascular permeation, presence of 1 to 4 involved lymph nodes, or 5 or more lymph nodes and the presence of an apical lymph node as variables with significant prognostic value. Conclusions: Our series confirms the prognostic importance of lymph node involvement. This parameter is incorporated in Jass, GITSG (both modifications of Dukes classification) and TNM staging scores. (Rev Méd Chile 2001; 129: 237-46).
author	Bannura C,Guillermo Cumsille G,Miguel A. Contreras P,Jaime Melo L,Carlos Barrera E,Alejandro Reinero C,Macarena Pardo T,Lorena
author_facet	Bannura C,Guillermo Cumsille G,Miguel A. Contreras P,Jaime Melo L,Carlos Barrera E,Alejandro Reinero C,Macarena Pardo T,Lorena
author_sort	Bannura C,Guillermo
title	Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
title_short	Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
title_full	Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
title_fullStr	Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
title_full_unstemmed	Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes
title_sort	factores pronósticos en el cáncer colorrectal: análisis multivariado de 224 pacientes
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300001
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Factores pronósticos en el cáncer colorrectal: Análisis multivariado de 224 pacientes

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