Rol del virus Herpes simplex en la queratitis inmune estromal

Background: Herpes simplex virus (HSV) infection of the cornea is a leading cause of blindness in occidental countries and a common recurrent manifestation of it is the immune stromal keratitis (ISK). However, it is not known whether active viral replication occurs during the acute phase of the dise...

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Autores principales:	Vinagre del P,Claudia, Martínez G,María José, Vogel G,Marlene, Traipe C,Leonidas, Stoppel O,Juan, Squella G,Olympia, Srur A,Miguel, Charlín E,Raimundo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Corneal diseases Keratitis Keratitis herpetic Herpes simplex
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300004
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spelling	oai:scielo:S0034-988720010003000042001-05-22Rol del virus Herpes simplex en la queratitis inmune estromalVinagre del P,ClaudiaMartínez G,María JoséVogel G,MarleneTraipe C,LeonidasStoppel O,JuanSquella G,OlympiaSrur A,MiguelCharlín E,Raimundo Corneal diseases Keratitis Keratitis herpetic Herpes simplex Background: Herpes simplex virus (HSV) infection of the cornea is a leading cause of blindness in occidental countries and a common recurrent manifestation of it is the immune stromal keratitis (ISK). However, it is not known whether active viral replication occurs during the acute phase of the disease, because isolation of the virus by conventional culture techniques has not been accomplished. Aim: To establish the presence of HSV in patients with ISK. Material and methods: Fourteen corneal swabbing samples, from active diseased eyes of patients with clinical diagnosis of ISK, were submitted to Herpchek® and PCR for the identification of HSV antigens and genome. Results: All ISK samples were negative by both techniques. Conclusions: It was not possible to identify HSV antigens nor their genome by the methodology used. It is likely that, they cant be detected in corneal superficial layers or probably there is no viral replication at this stage of the disease, so antiviral therapy should be reconsidered. (Rev Méd Chile 2001; 129: 259-63).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.3 20012001-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300004es10.4067/S0034-98872001000300004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Corneal diseases Keratitis Keratitis herpetic Herpes simplex
spellingShingle	Corneal diseases Keratitis Keratitis herpetic Herpes simplex Vinagre del P,Claudia Martínez G,María José Vogel G,Marlene Traipe C,Leonidas Stoppel O,Juan Squella G,Olympia Srur A,Miguel Charlín E,Raimundo Rol del virus Herpes simplex en la queratitis inmune estromal
description	Background: Herpes simplex virus (HSV) infection of the cornea is a leading cause of blindness in occidental countries and a common recurrent manifestation of it is the immune stromal keratitis (ISK). However, it is not known whether active viral replication occurs during the acute phase of the disease, because isolation of the virus by conventional culture techniques has not been accomplished. Aim: To establish the presence of HSV in patients with ISK. Material and methods: Fourteen corneal swabbing samples, from active diseased eyes of patients with clinical diagnosis of ISK, were submitted to Herpchek® and PCR for the identification of HSV antigens and genome. Results: All ISK samples were negative by both techniques. Conclusions: It was not possible to identify HSV antigens nor their genome by the methodology used. It is likely that, they cant be detected in corneal superficial layers or probably there is no viral replication at this stage of the disease, so antiviral therapy should be reconsidered. (Rev Méd Chile 2001; 129: 259-63).
author	Vinagre del P,Claudia Martínez G,María José Vogel G,Marlene Traipe C,Leonidas Stoppel O,Juan Squella G,Olympia Srur A,Miguel Charlín E,Raimundo
author_facet	Vinagre del P,Claudia Martínez G,María José Vogel G,Marlene Traipe C,Leonidas Stoppel O,Juan Squella G,Olympia Srur A,Miguel Charlín E,Raimundo
author_sort	Vinagre del P,Claudia
title	Rol del virus Herpes simplex en la queratitis inmune estromal
title_short	Rol del virus Herpes simplex en la queratitis inmune estromal
title_full	Rol del virus Herpes simplex en la queratitis inmune estromal
title_fullStr	Rol del virus Herpes simplex en la queratitis inmune estromal
title_full_unstemmed	Rol del virus Herpes simplex en la queratitis inmune estromal
title_sort	rol del virus herpes simplex en la queratitis inmune estromal
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000300004
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Rol del virus Herpes simplex en la queratitis inmune estromal

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