La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica

Background: Patients with chronic cardiac failure often have elevated plasma uric acid levels, that are associated to a dismal prognosis. Aim: To investigate possible metabolic mechanisms to explain elevated uric acid levels in these patients. Patients and methods: Eighteen patients with chronic car...

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Autores principales:	Martínez S,Alejandro, Pérez C,Pedro, Ossa A,Cristóbal, Corbalán H,Ramón, Jalil M,Jorge, Castro G,Pablo, Acevedo B,Mónica
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Anoxia Cardiac output, low Oximetry Oxygen Uric acid
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500005
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spelling	oai:scielo:S0034-988720010005000052005-11-24La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónicaMartínez S,AlejandroPérez C,PedroOssa A,CristóbalCorbalán H,RamónJalil M,JorgeCastro G,PabloAcevedo B,Mónica Anoxia Cardiac output, low Oximetry Oxygen Uric acid Background: Patients with chronic cardiac failure often have elevated plasma uric acid levels, that are associated to a dismal prognosis. Aim: To investigate possible metabolic mechanisms to explain elevated uric acid levels in these patients. Patients and methods: Eighteen patients with chronic cardiac failure aged 61 ± 10 years old, without gout or renal failure and not using high doses of diuretics (equal or less than 80 mg/day furosemide or 50 mg/day hydrochlorothiazide) were studied. Plasma uric acid levels were correlated with anaerobic threshold, maximal oxygen uptake, plasma noradrenaline and creatinine and left ventricular ejection fraction, measured radioisotopically. Results: Mean maximal oxygen uptake was 16.6 ± 4.2 ml/kg/min. There was a negative correlation between uric acid levels and maximal oxygen uptake or maximal oxygen uptake/body surface area (r=0.521 and -0.533 respectively, p<0.05). Patients with uric acid levels over 7 mg/dl had a lower anaerobic threshold than patients with lower levels (9.81 ± 2.41 and 13.08 ± 3.28 ml/kg/min respectively, p<0.05). No significant differences in maximal oxygen uptake were observed in these two groups of patients (15.5 ± 4.24 and 18.08 ± 3.86 ml/kg/min respectively). Uric acid levels did not correlate with plasma noradrenaline, creatinine or lefi ventricular ejection fraction. Conclusions: These results suggest that a defect in cellular oxygenation contributes to the elevation of plasma uric acid levels in patients with chronic cardiac failure. (Rev Méd Chile 2001; 129: 503-8)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.5 20012001-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500005es10.4067/S0034-98872001000500005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anoxia Cardiac output, low Oximetry Oxygen Uric acid
spellingShingle	Anoxia Cardiac output, low Oximetry Oxygen Uric acid Martínez S,Alejandro Pérez C,Pedro Ossa A,Cristóbal Corbalán H,Ramón Jalil M,Jorge Castro G,Pablo Acevedo B,Mónica La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
description	Background: Patients with chronic cardiac failure often have elevated plasma uric acid levels, that are associated to a dismal prognosis. Aim: To investigate possible metabolic mechanisms to explain elevated uric acid levels in these patients. Patients and methods: Eighteen patients with chronic cardiac failure aged 61 ± 10 years old, without gout or renal failure and not using high doses of diuretics (equal or less than 80 mg/day furosemide or 50 mg/day hydrochlorothiazide) were studied. Plasma uric acid levels were correlated with anaerobic threshold, maximal oxygen uptake, plasma noradrenaline and creatinine and left ventricular ejection fraction, measured radioisotopically. Results: Mean maximal oxygen uptake was 16.6 ± 4.2 ml/kg/min. There was a negative correlation between uric acid levels and maximal oxygen uptake or maximal oxygen uptake/body surface area (r=0.521 and -0.533 respectively, p<0.05). Patients with uric acid levels over 7 mg/dl had a lower anaerobic threshold than patients with lower levels (9.81 ± 2.41 and 13.08 ± 3.28 ml/kg/min respectively, p<0.05). No significant differences in maximal oxygen uptake were observed in these two groups of patients (15.5 ± 4.24 and 18.08 ± 3.86 ml/kg/min respectively). Uric acid levels did not correlate with plasma noradrenaline, creatinine or lefi ventricular ejection fraction. Conclusions: These results suggest that a defect in cellular oxygenation contributes to the elevation of plasma uric acid levels in patients with chronic cardiac failure. (Rev Méd Chile 2001; 129: 503-8)
author	Martínez S,Alejandro Pérez C,Pedro Ossa A,Cristóbal Corbalán H,Ramón Jalil M,Jorge Castro G,Pablo Acevedo B,Mónica
author_facet	Martínez S,Alejandro Pérez C,Pedro Ossa A,Cristóbal Corbalán H,Ramón Jalil M,Jorge Castro G,Pablo Acevedo B,Mónica
author_sort	Martínez S,Alejandro
title	La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
title_short	La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
title_full	La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
title_fullStr	La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
title_full_unstemmed	La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
title_sort	la hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500005
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La hiperuricemia es un marcador del umbral anaeróbico en la insuficiencia cardíaca crónica

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