ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica

Background: There is an urgent need to assess the impact, on the incidence of neural tube defects, of the recently implanted flour fortification with folic acid in Chile. The Collaborative Study of Congenital Malformations in Latin America (ECLAMC) has carried out an uninterrupted register of congen...

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Autores principales:	Nazer H,Julio, López-Camelo,Jorge, Castilla,Eduardo E
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Abnormalities Genetics, medical Neural tube defects
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500009
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spelling	oai:scielo:S0034-988720010005000092005-11-24ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en LatinoaméricaNazer H,JulioLópez-Camelo,JorgeCastilla,Eduardo E Abnormalities Genetics, medical Neural tube defects Background: There is an urgent need to assess the impact, on the incidence of neural tube defects, of the recently implanted flour fortification with folic acid in Chile. The Collaborative Study of Congenital Malformations in Latin America (ECLAMC) has carried out an uninterrupted register of congenital malformations in the last thirty years Aim: To assess the epidemiology of neural tube defects in Chile and determine the most adequate base period to evaluate the effects of Folic acid fortification. Material and methods: analysis of ECLAMC database that has registered all births over 500 g from 1967. Results: From 1967 to 1999, there were 434.624 births in 18 hospitals in Chile and 3.586.569 births in 155 hospitals in the rest of Latin America. The rate of neural tube defects in Chile was 17.03 per 10.000, significantly higher than the rest of ECLAMC (14.88 per 10.000). The prevalence of neural tube defects has a statistically significant secular tendency to increase in the study period and is higher among stillbirths, newborns with a birth weight of less than 1500 g, women and offspring of mothers aged less than 19 years old. Conclusions: The period 1982-1999 is considered the best period for reference comparisons of the effects folic acid supplementation (Rev Méd Chile 2001; 129: 531-9)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.5 20012001-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500009es10.4067/S0034-98872001000500009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Abnormalities Genetics, medical Neural tube defects
spellingShingle	Abnormalities Genetics, medical Neural tube defects Nazer H,Julio López-Camelo,Jorge Castilla,Eduardo E ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
description	Background: There is an urgent need to assess the impact, on the incidence of neural tube defects, of the recently implanted flour fortification with folic acid in Chile. The Collaborative Study of Congenital Malformations in Latin America (ECLAMC) has carried out an uninterrupted register of congenital malformations in the last thirty years Aim: To assess the epidemiology of neural tube defects in Chile and determine the most adequate base period to evaluate the effects of Folic acid fortification. Material and methods: analysis of ECLAMC database that has registered all births over 500 g from 1967. Results: From 1967 to 1999, there were 434.624 births in 18 hospitals in Chile and 3.586.569 births in 155 hospitals in the rest of Latin America. The rate of neural tube defects in Chile was 17.03 per 10.000, significantly higher than the rest of ECLAMC (14.88 per 10.000). The prevalence of neural tube defects has a statistically significant secular tendency to increase in the study period and is higher among stillbirths, newborns with a birth weight of less than 1500 g, women and offspring of mothers aged less than 19 years old. Conclusions: The period 1982-1999 is considered the best period for reference comparisons of the effects folic acid supplementation (Rev Méd Chile 2001; 129: 531-9)
author	Nazer H,Julio López-Camelo,Jorge Castilla,Eduardo E
author_facet	Nazer H,Julio López-Camelo,Jorge Castilla,Eduardo E
author_sort	Nazer H,Julio
title	ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
title_short	ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
title_full	ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
title_fullStr	ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
title_full_unstemmed	ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica
title_sort	eclamc: estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en chile y en latinoamérica
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500009
work_keys_str_mv	AT nazerhjulio eclamcestudiode30anosdevigilanciaepidemiologicadedefectosdetuboneuralenchileyenlatinoamerica AT lopezcamelojorge eclamcestudiode30anosdevigilanciaepidemiologicadedefectosdetuboneuralenchileyenlatinoamerica AT castillaeduardoe eclamcestudiode30anosdevigilanciaepidemiologicadedefectosdetuboneuralenchileyenlatinoamerica
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ECLAMC: Estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica

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