Alzheimer disease: 100 years later

Almost 100 years since the first clinical report of a case of Alzheimer disease (AD), three early-onset and two late-onset AD genes have been identified. While rare mutations in the early-onset genes (amyloid precursor protein, and presenilins 1 and 2) lead to increased generation of specific forms...

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Autores principales:	Puglielli MD,Luigi, M Kovacs PhD,Dora
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Alzheimer disease Amyloid beta-Protein Genetics, biochemical Molecular biology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500015
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spelling	oai:scielo:S0034-988720010005000152005-11-24Alzheimer disease: 100 years laterPuglielli MD,LuigiM Kovacs PhD,Dora Alzheimer disease Amyloid beta-Protein Genetics, biochemical Molecular biology Almost 100 years since the first clinical report of a case of Alzheimer disease (AD), three early-onset and two late-onset AD genes have been identified. While rare mutations in the early-onset genes (amyloid precursor protein, and presenilins 1 and 2) lead to increased generation of specific forms of the amyloid ß protein (A,ß), common polymorphisms in the late-onset genes (apolipoprotein E and alpha²-macroglobulin) are thought to alter the clearance and degradation of A,ß in brain. Although definite proof for a direct link between altered A ß generation/clearance and neurodegeneration has not yet been attained, mechanism-based approaches for the therapeutic treatment of AD based on lowering levels of the potentially pathogenic Aß are currently underway. The recent discovery of the enzymes (secretases) responsible for generating Aß have paved the way for the development of such drugs and increase the prospects for successful therapeutic intervention to arrest AD neuropathogenesis (Rev Méd Chile 2001; 129: 569-75)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.5 20012001-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500015en10.4067/S0034-98872001000500015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alzheimer disease Amyloid beta-Protein Genetics, biochemical Molecular biology
spellingShingle	Alzheimer disease Amyloid beta-Protein Genetics, biochemical Molecular biology Puglielli MD,Luigi M Kovacs PhD,Dora Alzheimer disease: 100 years later
description	Almost 100 years since the first clinical report of a case of Alzheimer disease (AD), three early-onset and two late-onset AD genes have been identified. While rare mutations in the early-onset genes (amyloid precursor protein, and presenilins 1 and 2) lead to increased generation of specific forms of the amyloid ß protein (A,ß), common polymorphisms in the late-onset genes (apolipoprotein E and alpha²-macroglobulin) are thought to alter the clearance and degradation of A,ß in brain. Although definite proof for a direct link between altered A ß generation/clearance and neurodegeneration has not yet been attained, mechanism-based approaches for the therapeutic treatment of AD based on lowering levels of the potentially pathogenic Aß are currently underway. The recent discovery of the enzymes (secretases) responsible for generating Aß have paved the way for the development of such drugs and increase the prospects for successful therapeutic intervention to arrest AD neuropathogenesis (Rev Méd Chile 2001; 129: 569-75)
author	Puglielli MD,Luigi M Kovacs PhD,Dora
author_facet	Puglielli MD,Luigi M Kovacs PhD,Dora
author_sort	Puglielli MD,Luigi
title	Alzheimer disease: 100 years later
title_short	Alzheimer disease: 100 years later
title_full	Alzheimer disease: 100 years later
title_fullStr	Alzheimer disease: 100 years later
title_full_unstemmed	Alzheimer disease: 100 years later
title_sort	alzheimer disease: 100 years later
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000500015
work_keys_str_mv	AT pugliellimdluigi alzheimerdisease100yearslater AT mkovacsphddora alzheimerdisease100yearslater
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Alzheimer disease: 100 years later

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