Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1

Background: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) can be present in patients with type I diabetes. Breast feeding duration and the early exposure to milk substitutes are envi...

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Autores principales:	Pérez-Bravo,Francisco, Riesco S,M. Virginia, Albala B,Cecilia, Oyarzún A,Amaya, Santos M,J Luis, Carrasco P,Elena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Antibodies Breast feeding Diabetes mellitus insulin-dependent
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600003
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spelling	oai:scielo:S0034-988720010006000032001-09-24Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1Pérez-Bravo,FranciscoRiesco S,M. VirginiaAlbala B,CeciliaOyarzún A,AmayaSantos M,J LuisCarrasco P,Elena Antibodies Breast feeding Diabetes mellitus insulin-dependent Background: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) can be present in patients with type I diabetes. Breast feeding duration and the early exposure to milk substitutes are environmental factors associated to etiology of type 1 diabetes. Aim To study the frequency of the anti-GAD, anti-IA-2 e ICA antibodies in Chilean type 1 diabetic patients and determine the possible modulator effect of the breast feeding. Patients and methods: One hundred thirty four type I diabetic patients, aged one to 15 years old, were studied at the moment of their diagnosis. Patients were classified according to the duration of exclusive breast feeding. IA-2 and GAD were determined by radio immuno assay and ICA by means of indirect immunofluorescence. Results: Subjects with three months or less and those with more than three months of breast feeding were positive for ICA in 78.8 and 90.6% of cases respectively, for GAD in 75 and 54.6% of cases respectively (p=0.024) and for IA-2 in 73 and 43.8% of cases respectively (p=0.001). All three antibodies were positive in 53.9 and 21.8% of children with less or more than three months of breast feeding (p=0.001). Conclusion: Both IA-2 and GAD antibodies are less frequently positive in type 1 diabetic patients who have been breast fed for more than three months. These findings suggest a possible attenuating role of exclusive breast feeding on pancreatic aggression events in patients with type 1 diabetes (Rev Méd Chile, 2001; 129: 611-9)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.6 20012001-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600003es10.4067/S0034-98872001000600003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibodies Breast feeding Diabetes mellitus insulin-dependent
spellingShingle	Antibodies Breast feeding Diabetes mellitus insulin-dependent Pérez-Bravo,Francisco Riesco S,M. Virginia Albala B,Cecilia Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
description	Background: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) can be present in patients with type I diabetes. Breast feeding duration and the early exposure to milk substitutes are environmental factors associated to etiology of type 1 diabetes. Aim To study the frequency of the anti-GAD, anti-IA-2 e ICA antibodies in Chilean type 1 diabetic patients and determine the possible modulator effect of the breast feeding. Patients and methods: One hundred thirty four type I diabetic patients, aged one to 15 years old, were studied at the moment of their diagnosis. Patients were classified according to the duration of exclusive breast feeding. IA-2 and GAD were determined by radio immuno assay and ICA by means of indirect immunofluorescence. Results: Subjects with three months or less and those with more than three months of breast feeding were positive for ICA in 78.8 and 90.6% of cases respectively, for GAD in 75 and 54.6% of cases respectively (p=0.024) and for IA-2 in 73 and 43.8% of cases respectively (p=0.001). All three antibodies were positive in 53.9 and 21.8% of children with less or more than three months of breast feeding (p=0.001). Conclusion: Both IA-2 and GAD antibodies are less frequently positive in type 1 diabetic patients who have been breast fed for more than three months. These findings suggest a possible attenuating role of exclusive breast feeding on pancreatic aggression events in patients with type 1 diabetes (Rev Méd Chile, 2001; 129: 611-9)
author	Pérez-Bravo,Francisco Riesco S,M. Virginia Albala B,Cecilia Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena
author_facet	Pérez-Bravo,Francisco Riesco S,M. Virginia Albala B,Cecilia Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena
author_sort	Pérez-Bravo,Francisco
title	Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
title_short	Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
title_full	Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
title_fullStr	Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
title_full_unstemmed	Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
title_sort	perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600003
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Perfil de auto-anticuerpos y lactancia materna en pacientes diabéticos tipo 1

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