Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente

Background: The clinical parameters for the suspicion of Clostridium difficile infections, namely the use of antimicrobials and diarrhea, have a low predictive value for the diagnosis. Aim: To search other clinical variables and determine a clinical prediction model for (Clostridium difficile diarrh...

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Autores principales:	Alvarez L,Manuel, González D,Robinson, Briceño L,Isabel, Cofre D,Colomba, Labarca L,Jaime, Vial C,Pablo, García C,Patricia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Clostridium difficile Diarrhea Enterocolitis, pseudomembranous
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600004
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spelling	oai:scielo:S0034-988720010006000042001-09-24Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficienteAlvarez L,ManuelGonzález D,RobinsonBriceño L,IsabelCofre D,ColombaLabarca L,JaimeVial C,PabloGarcía C,Patricia Clostridium difficile Diarrhea Enterocolitis, pseudomembranous Background: The clinical parameters for the suspicion of Clostridium difficile infections, namely the use of antimicrobials and diarrhea, have a low predictive value for the diagnosis. Aim: To search other clinical variables and determine a clinical prediction model for (Clostridium difficile diarrhea. Patients and methods: All patients to whom a Clostridium difficile study was requested, were prospectively studied during 5 months. Clinical variables of these patients were registered. The diagnosis of Clostridium difficile was done using the cytotoxicity test in fibroblast cultures. Results: Ninety two patients were analyzed and in 26, the diagnosis of Clostridium difficile was confirmed. A logistic regression model disclosed an age over 60 years old, the presence of mucus in the stools and a temperature over 37.8 °C in the previous 24 h, as significant predictors of the infection. The correlation of the model, between the predicted probability and the observed condition, was 81.5%. Conclusions: The presence of the clinical variables identified in this study are associated with a high probability of an infection by Clostridium difficile in patients with diarrhea and the recent use of antimicrobials (Rev Méd Chile 2001; 129: 620-625)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.6 20012001-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600004es10.4067/S0034-98872001000600004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Clostridium difficile Diarrhea Enterocolitis, pseudomembranous
spellingShingle	Clostridium difficile Diarrhea Enterocolitis, pseudomembranous Alvarez L,Manuel González D,Robinson Briceño L,Isabel Cofre D,Colomba Labarca L,Jaime Vial C,Pablo García C,Patricia Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
description	Background: The clinical parameters for the suspicion of Clostridium difficile infections, namely the use of antimicrobials and diarrhea, have a low predictive value for the diagnosis. Aim: To search other clinical variables and determine a clinical prediction model for (Clostridium difficile diarrhea. Patients and methods: All patients to whom a Clostridium difficile study was requested, were prospectively studied during 5 months. Clinical variables of these patients were registered. The diagnosis of Clostridium difficile was done using the cytotoxicity test in fibroblast cultures. Results: Ninety two patients were analyzed and in 26, the diagnosis of Clostridium difficile was confirmed. A logistic regression model disclosed an age over 60 years old, the presence of mucus in the stools and a temperature over 37.8 °C in the previous 24 h, as significant predictors of the infection. The correlation of the model, between the predicted probability and the observed condition, was 81.5%. Conclusions: The presence of the clinical variables identified in this study are associated with a high probability of an infection by Clostridium difficile in patients with diarrhea and the recent use of antimicrobials (Rev Méd Chile 2001; 129: 620-625)
author	Alvarez L,Manuel González D,Robinson Briceño L,Isabel Cofre D,Colomba Labarca L,Jaime Vial C,Pablo García C,Patricia
author_facet	Alvarez L,Manuel González D,Robinson Briceño L,Isabel Cofre D,Colomba Labarca L,Jaime Vial C,Pablo García C,Patricia
author_sort	Alvarez L,Manuel
title	Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
title_short	Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
title_full	Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
title_fullStr	Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
title_full_unstemmed	Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente
title_sort	diagnóstico de diarrea por clostridium difficile: en busca de un enfoque clínico más eficiente
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000600004
work_keys_str_mv	AT alvarezlmanuel diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT gonzalezdrobinson diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT bricenolisabel diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT cofredcolomba diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT labarcaljaime diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT vialcpablo diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente AT garciacpatricia diagnosticodediarreaporclostridiumdifficileenbuscadeunenfoqueclinicomaseficiente
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Diagnóstico de diarrea por Clostridium difficile: en busca de un enfoque clínico más eficiente

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