Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico

Background: About 60% of patients with polycystic ovary syndrome (PCOS) have insulin resistance, predisposing them to the premature coronary disease and type 2 -diabetes mellitus. However, the history of metabolic disorders in family members of patients with PCOS has been seldom documented in the li...

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Autores principales:	Benítez M,Ricardo, Sir-Petermann,Teresa, Palomino A,Alberto, Angel B,Bárbara, Maliqueo Y,Manuel, Pérez B,Francisco, Calvillán C,Marcelo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Insulin resistance Polycystic ovary syndrome Reproductive, medicine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700001
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spelling	oai:scielo:S0034-988720010007000012005-11-22Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquísticoBenítez M,RicardoSir-Petermann,TeresaPalomino A,AlbertoAngel B,BárbaraMaliqueo Y,ManuelPérez B,FranciscoCalvillán C,Marcelo Insulin resistance Polycystic ovary syndrome Reproductive, medicine Background: About 60% of patients with polycystic ovary syndrome (PCOS) have insulin resistance, predisposing them to the premature coronary disease and type 2 -diabetes mellitus. However, the history of metabolic disorders in family members of patients with PCOS has been seldom documented in the literature. Aim: To evaluate the family profile of metabolic disorders of PCOS patients and to determine their relative risk of developing one of them in comparison to a control group. Patients and Methods: Sixty PCOS patients were evaluated. The control group were 60 normal women. The data were obtained from the clinical history and personal interview with the patients, the controls and their relatives (brothers, parents and grandparents). The metabolic disorders considered were: dyslipidemia, obesity, hypertension and diabetes. Results: The ages were similar between groups (PCOS: 24.0 ± 6.3; control group: 24.8 ± 6.2 years). The prevalence of metabolic disorders was 62% in the relatives of the PCOS patients and 27.8% in the relatives of the control group (p <0.005). The probability to develop a metabolic disorder within the family was 2.7 (2.2-3.3) fold higher in the PCOS group compared to the control group. The risk of developing hypertension, dyslipidemia, obesity and diabetes was 2.1 (1.5-2.9); 1.8 (1.5-2.7); 3.6 (2.6-4.9) and 2.7 (1.8-3.9), respectively, in the PCOS group compared to the control group. Conclusions: The probability of finding a metabolic disorder in the families of PCOS patients, is 2.7 fold higher than in the control group families. The metabolic disorders are more frequent in parents and grandparents of the PCOS patients than in those of normal women (Rev Méd Chile 2001; 129: 707-12)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.7 20012001-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700001es10.4067/S0034-98872001000700001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Insulin resistance Polycystic ovary syndrome Reproductive, medicine
spellingShingle	Insulin resistance Polycystic ovary syndrome Reproductive, medicine Benítez M,Ricardo Sir-Petermann,Teresa Palomino A,Alberto Angel B,Bárbara Maliqueo Y,Manuel Pérez B,Francisco Calvillán C,Marcelo Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
description	Background: About 60% of patients with polycystic ovary syndrome (PCOS) have insulin resistance, predisposing them to the premature coronary disease and type 2 -diabetes mellitus. However, the history of metabolic disorders in family members of patients with PCOS has been seldom documented in the literature. Aim: To evaluate the family profile of metabolic disorders of PCOS patients and to determine their relative risk of developing one of them in comparison to a control group. Patients and Methods: Sixty PCOS patients were evaluated. The control group were 60 normal women. The data were obtained from the clinical history and personal interview with the patients, the controls and their relatives (brothers, parents and grandparents). The metabolic disorders considered were: dyslipidemia, obesity, hypertension and diabetes. Results: The ages were similar between groups (PCOS: 24.0 ± 6.3; control group: 24.8 ± 6.2 years). The prevalence of metabolic disorders was 62% in the relatives of the PCOS patients and 27.8% in the relatives of the control group (p <0.005). The probability to develop a metabolic disorder within the family was 2.7 (2.2-3.3) fold higher in the PCOS group compared to the control group. The risk of developing hypertension, dyslipidemia, obesity and diabetes was 2.1 (1.5-2.9); 1.8 (1.5-2.7); 3.6 (2.6-4.9) and 2.7 (1.8-3.9), respectively, in the PCOS group compared to the control group. Conclusions: The probability of finding a metabolic disorder in the families of PCOS patients, is 2.7 fold higher than in the control group families. The metabolic disorders are more frequent in parents and grandparents of the PCOS patients than in those of normal women (Rev Méd Chile 2001; 129: 707-12)
author	Benítez M,Ricardo Sir-Petermann,Teresa Palomino A,Alberto Angel B,Bárbara Maliqueo Y,Manuel Pérez B,Francisco Calvillán C,Marcelo
author_facet	Benítez M,Ricardo Sir-Petermann,Teresa Palomino A,Alberto Angel B,Bárbara Maliqueo Y,Manuel Pérez B,Francisco Calvillán C,Marcelo
author_sort	Benítez M,Ricardo
title	Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
title_short	Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
title_full	Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
title_fullStr	Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
title_full_unstemmed	Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
title_sort	prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700001
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Prevalencia familiar de patologías metabólicas en pacientes con síndrome de ovario poliquístico

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