Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)

Background: Acute bacterial meningitis still has a high mortality and rate of complications. Aim: To assess the impact of anti H influenzae vaccination on the epidemiology of acute bacterial meningitis in Chilean children. Material and methods: A retrospective study of hospital discharge records of...

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Autores principales:	Díaz P,José Manuel, Catalán N,Lía, Urrutia L,María Teresa, Prado J,Valeria, Ledermann D,Walter, Mendoza N,Carmen, Topelberg V,Santiago
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Harmophilus influenzae type b Meningitis, bacterial Meningitis haemophily Vaccination
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700003
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spelling	oai:scielo:S0034-988720010007000032005-11-22Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)Díaz P,José ManuelCatalán N,LíaUrrutia L,María TeresaPrado J,ValeriaLedermann D,WalterMendoza N,CarmenTopelberg V,Santiago Harmophilus influenzae type b Meningitis, bacterial Meningitis haemophily Vaccination Background: Acute bacterial meningitis still has a high mortality and rate of complications. Aim: To assess the impact of anti H influenzae vaccination on the epidemiology of acute bacterial meningitis in Chilean children. Material and methods: A retrospective study of hospital discharge records of patients with acute bacterial meningitis. Causative agents were studied globally, by hospital and by age group. The changes in etiology from 1989 to 1995 were also assessed. Between 1996 and 1998, only those patients with acute bacterial meningitis caused by H influenzae were recollected. Results: In the period prior to vaccination (1989-1995), 1000 cases were registered. The main causative agents were N meningitidis in 33.8%, H influenzas type b in 21.9% and S pneumoniae in 15.4%. The incidence of H influenzae decreased in the period from 36.4 to 9.9% (p<0.001) and the incidence of N meningitidis increased from 22.9 to 52.1% (p <0.001). The incidence of S pneumoniae did not change significantly. H influenzae predominated in children between 4 and 24 months of age and N meningitidis predominated in children over 25 months of age. In the period after the introduction of vaccination (1995-1998), there was a further decrease in the incidence of H influenzae from 10 to 2% (p <0.001). Until 1997, there was a considerable increase in the incidence of N meningitidis, specially in children over 25 months of age. It declined in 1998 to 38%. Conclusions: There was a reduction in the incidence of acute bacterial meningitis caused by H influenzae prior to the introduction of the vaccine against H influenzae type b. The decrease was more pronounced after the introduction of the vaccine (Rev Méd Chile 2001; 129: 719-26)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.7 20012001-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700003es10.4067/S0034-98872001000700003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Harmophilus influenzae type b Meningitis, bacterial Meningitis haemophily Vaccination
spellingShingle	Harmophilus influenzae type b Meningitis, bacterial Meningitis haemophily Vaccination Díaz P,José Manuel Catalán N,Lía Urrutia L,María Teresa Prado J,Valeria Ledermann D,Walter Mendoza N,Carmen Topelberg V,Santiago Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
description	Background: Acute bacterial meningitis still has a high mortality and rate of complications. Aim: To assess the impact of anti H influenzae vaccination on the epidemiology of acute bacterial meningitis in Chilean children. Material and methods: A retrospective study of hospital discharge records of patients with acute bacterial meningitis. Causative agents were studied globally, by hospital and by age group. The changes in etiology from 1989 to 1995 were also assessed. Between 1996 and 1998, only those patients with acute bacterial meningitis caused by H influenzae were recollected. Results: In the period prior to vaccination (1989-1995), 1000 cases were registered. The main causative agents were N meningitidis in 33.8%, H influenzas type b in 21.9% and S pneumoniae in 15.4%. The incidence of H influenzae decreased in the period from 36.4 to 9.9% (p<0.001) and the incidence of N meningitidis increased from 22.9 to 52.1% (p <0.001). The incidence of S pneumoniae did not change significantly. H influenzae predominated in children between 4 and 24 months of age and N meningitidis predominated in children over 25 months of age. In the period after the introduction of vaccination (1995-1998), there was a further decrease in the incidence of H influenzae from 10 to 2% (p <0.001). Until 1997, there was a considerable increase in the incidence of N meningitidis, specially in children over 25 months of age. It declined in 1998 to 38%. Conclusions: There was a reduction in the incidence of acute bacterial meningitis caused by H influenzae prior to the introduction of the vaccine against H influenzae type b. The decrease was more pronounced after the introduction of the vaccine (Rev Méd Chile 2001; 129: 719-26)
author	Díaz P,José Manuel Catalán N,Lía Urrutia L,María Teresa Prado J,Valeria Ledermann D,Walter Mendoza N,Carmen Topelberg V,Santiago
author_facet	Díaz P,José Manuel Catalán N,Lía Urrutia L,María Teresa Prado J,Valeria Ledermann D,Walter Mendoza N,Carmen Topelberg V,Santiago
author_sort	Díaz P,José Manuel
title	Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
title_short	Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
title_full	Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
title_fullStr	Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
title_full_unstemmed	Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)
title_sort	tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: impacto de la vacuna anti-h influenzae tipo b (hib)
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700003
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Tendencias en la etiología de la meningitis bacteriana aguda en niños chilenos, período 1989-1998.: Impacto de la vacuna anti-H influenzae tipo b (Hib)

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