Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas

Background: HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a defined entity. However, there are many patients not well characterized with a similar clinical picture who are HTLV-I seronegative. Objective: Clinical and neurophysiological description of patients with HTLV-I ser...

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Autores principales:	Castillo C,José Luis, Cea M,Gabriel, Cartier R,Luis, Verdugo L,Renato
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Progressive spastic paraparesis HTLV-I Quantitative Somatosensory Thermotest Somatosensory Evoked Potentials Vibratory Sensory Analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700005
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spelling	oai:scielo:S0034-988720010007000052005-11-22Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivasCastillo C,José LuisCea M,GabrielCartier R,LuisVerdugo L,Renato Progressive spastic paraparesis HTLV-I Quantitative Somatosensory Thermotest Somatosensory Evoked Potentials Vibratory Sensory Analysis Background: HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a defined entity. However, there are many patients not well characterized with a similar clinical picture who are HTLV-I seronegative. Objective: Clinical and neurophysiological description of patients with HTLV-I seronegative idiopathic paraparesia. Patients and Methods: Seventeen patients (4 women and 13 men aged 24-67 years, average 52.3) were evaluated including clinical assessment, vibratory sensory analysis, quantitative somatosensory thermotest (QST), somatosensory evoked potentials (SSEPs), electromyography (EMG) and motor and sensory nerve conductions. Results: In addition to the spastic paraparesis, 3 (17.6%) patients had pseudobulbar symptoms. Ten (58.8%) patients had a spastic gait but could walk unaided, 6 (35.2%) needed support and 1 patient could not walk. Bladder dysfunction was found in 10 (58.8) patients and sensory symptoms in 7 (41.1%). There was mild distal impairment of vibration and position sense, distal tactile and pinprick hypoesthesia in 4 (23.4%) patients. Tibial SSEPs were abnormal in 11 (64.7%). Nerve conduction studies and EMG were normal. QST showed cold hypoesthesia in 14 (82.4%) patients. Warm sensation and heat pain appeared unimpaired. Conclusions: All sensory abnormalities found were restricted to sensations carried by myelinated (A beta and A delta) channels. Sensory and motor abnormalities are similar to HAM/TSP patients suggesting a common pathogenesis (Rev Méd Chile 2001; 129: 731-41)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.7 20012001-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700005es10.4067/S0034-98872001000700005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Progressive spastic paraparesis HTLV-I Quantitative Somatosensory Thermotest Somatosensory Evoked Potentials Vibratory Sensory Analysis
spellingShingle	Progressive spastic paraparesis HTLV-I Quantitative Somatosensory Thermotest Somatosensory Evoked Potentials Vibratory Sensory Analysis Castillo C,José Luis Cea M,Gabriel Cartier R,Luis Verdugo L,Renato Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
description	Background: HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a defined entity. However, there are many patients not well characterized with a similar clinical picture who are HTLV-I seronegative. Objective: Clinical and neurophysiological description of patients with HTLV-I seronegative idiopathic paraparesia. Patients and Methods: Seventeen patients (4 women and 13 men aged 24-67 years, average 52.3) were evaluated including clinical assessment, vibratory sensory analysis, quantitative somatosensory thermotest (QST), somatosensory evoked potentials (SSEPs), electromyography (EMG) and motor and sensory nerve conductions. Results: In addition to the spastic paraparesis, 3 (17.6%) patients had pseudobulbar symptoms. Ten (58.8%) patients had a spastic gait but could walk unaided, 6 (35.2%) needed support and 1 patient could not walk. Bladder dysfunction was found in 10 (58.8) patients and sensory symptoms in 7 (41.1%). There was mild distal impairment of vibration and position sense, distal tactile and pinprick hypoesthesia in 4 (23.4%) patients. Tibial SSEPs were abnormal in 11 (64.7%). Nerve conduction studies and EMG were normal. QST showed cold hypoesthesia in 14 (82.4%) patients. Warm sensation and heat pain appeared unimpaired. Conclusions: All sensory abnormalities found were restricted to sensations carried by myelinated (A beta and A delta) channels. Sensory and motor abnormalities are similar to HAM/TSP patients suggesting a common pathogenesis (Rev Méd Chile 2001; 129: 731-41)
author	Castillo C,José Luis Cea M,Gabriel Cartier R,Luis Verdugo L,Renato
author_facet	Castillo C,José Luis Cea M,Gabriel Cartier R,Luis Verdugo L,Renato
author_sort	Castillo C,José Luis
title	Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
title_short	Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
title_full	Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
title_fullStr	Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
title_full_unstemmed	Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas
title_sort	paraparesia espástica progresiva idiopática htlv-i seronegativa: estudio clínico y neurofisiológico de las manifestaciones sensitivas
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700005
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Paraparesia espástica progresiva idiopática HTLV-I seronegativa: Estudio clínico y neurofisiológico de las manifestaciones sensitivas

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