Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren

Background: Renal transplant is the best therapeutic alternative for chronic renal failure, although it is not exempt of risks. Aim: To report the survival of renal transplant recipients and grafts and the main complications at a public hospital in Chile. Patients and methods: This is a non experime...

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Autores principales:	Poblete B,Hugo, Toro C,José, Nicovani H,Víctor, Cevallos P,Mónica, Orriols W,Miguel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Azathioprine Cyclosporine Kidney transplantation Transplantation, homologou
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700009
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spelling	oai:scielo:S0034-988720010007000092005-11-22Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van BurenPoblete B,HugoToro C,JoséNicovani H,VíctorCevallos P,MónicaOrriols W,Miguel Azathioprine Cyclosporine Kidney transplantation Transplantation, homologou Background: Renal transplant is the best therapeutic alternative for chronic renal failure, although it is not exempt of risks. Aim: To report the survival of renal transplant recipients and grafts and the main complications at a public hospital in Chile. Patients and methods: This is a non experimental, open historical cohort study, with reposition of the first 100 transplants in 94 patients, performed at the Carlos van Buren Hospital between 1984 and 1998. Seventy grafts came from cadaveric donors and 30 from live donors. As immunosuppressive therapy, prednisone + azathioprine was used in 48 transplants and the same regimen plus cyclosporine in 52. Results: Mean age of recipients was 36 ± 23 years old. Ten years actuarial survival of patients was 80.5% in transplants from cadaveric donors and 86% in transplants from live donors. Ten years graft survival was 57.5% in transplants from cadaveric donors and 42% in transplants from live donors. The period in which the transplant was performed (first or second half of the observation period), type of donor, HLA B-DR compatibility and sensitization (% PRA) had no effect on survival. Twenty five subjects lost their graft, 12 due to acute steroid resistant rejection, 10 due to chronic graft nephropathy and three due to renal artery thrombosis. Fifteen subjects died with a functioning graft, 10 due to infections, two due to an acute myocardial infarction, two due to an acute pancreatitis and one due to a brain tumor. Conclusions: Survival of grafts and renal transplant recipients was not influenced by the type of donor, period of transplantation and immune variables. Main causes of recipient death were infections and the main cause of graft failure was acute rejection (Rev Méd Chile 2001; 763-72).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.7 20012001-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700009es10.4067/S0034-98872001000700009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Azathioprine Cyclosporine Kidney transplantation Transplantation, homologou
spellingShingle	Azathioprine Cyclosporine Kidney transplantation Transplantation, homologou Poblete B,Hugo Toro C,José Nicovani H,Víctor Cevallos P,Mónica Orriols W,Miguel Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
description	Background: Renal transplant is the best therapeutic alternative for chronic renal failure, although it is not exempt of risks. Aim: To report the survival of renal transplant recipients and grafts and the main complications at a public hospital in Chile. Patients and methods: This is a non experimental, open historical cohort study, with reposition of the first 100 transplants in 94 patients, performed at the Carlos van Buren Hospital between 1984 and 1998. Seventy grafts came from cadaveric donors and 30 from live donors. As immunosuppressive therapy, prednisone + azathioprine was used in 48 transplants and the same regimen plus cyclosporine in 52. Results: Mean age of recipients was 36 ± 23 years old. Ten years actuarial survival of patients was 80.5% in transplants from cadaveric donors and 86% in transplants from live donors. Ten years graft survival was 57.5% in transplants from cadaveric donors and 42% in transplants from live donors. The period in which the transplant was performed (first or second half of the observation period), type of donor, HLA B-DR compatibility and sensitization (% PRA) had no effect on survival. Twenty five subjects lost their graft, 12 due to acute steroid resistant rejection, 10 due to chronic graft nephropathy and three due to renal artery thrombosis. Fifteen subjects died with a functioning graft, 10 due to infections, two due to an acute myocardial infarction, two due to an acute pancreatitis and one due to a brain tumor. Conclusions: Survival of grafts and renal transplant recipients was not influenced by the type of donor, period of transplantation and immune variables. Main causes of recipient death were infections and the main cause of graft failure was acute rejection (Rev Méd Chile 2001; 763-72).
author	Poblete B,Hugo Toro C,José Nicovani H,Víctor Cevallos P,Mónica Orriols W,Miguel
author_facet	Poblete B,Hugo Toro C,José Nicovani H,Víctor Cevallos P,Mónica Orriols W,Miguel
author_sort	Poblete B,Hugo
title	Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
title_short	Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
title_full	Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
title_fullStr	Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
title_full_unstemmed	Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren
title_sort	sobrevida del injerto en los primeros 100 trasplantes renales del hospital carlos van buren
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000700009
work_keys_str_mv	AT pobletebhugo sobrevidadelinjertoenlosprimeros100trasplantesrenalesdelhospitalcarlosvanburen AT torocjose sobrevidadelinjertoenlosprimeros100trasplantesrenalesdelhospitalcarlosvanburen AT nicovanihvictor sobrevidadelinjertoenlosprimeros100trasplantesrenalesdelhospitalcarlosvanburen AT cevallospmonica sobrevidadelinjertoenlosprimeros100trasplantesrenalesdelhospitalcarlosvanburen AT orriolswmiguel sobrevidadelinjertoenlosprimeros100trasplantesrenalesdelhospitalcarlosvanburen
_version_	1718435981495894016

Sobrevida del injerto en los primeros 100 trasplantes renales del Hospital Carlos van Buren

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