Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica

Background: No intravenous multivitamin formulation is available at the Chilean market that fulfills the requirements of pediatric patients on total parenteral nutrition. Therefore, adult formulations must be used. Aim: To prepare a parenteral aqueous multivitamin solution, to be used in pediatric p...

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Autores principales:	Carreño G,Patricia, Rosas E,Andrea, Rojas E,Irene
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Nutritional requirements Parenteral nutrition, total Pediatrics Vitamins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000800009
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spelling	oai:scielo:S0034-988720010008000092001-10-29Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátricaCarreño G,PatriciaRosas E,AndreaRojas E,Irene Nutritional requirements Parenteral nutrition, total Pediatrics Vitamins Background: No intravenous multivitamin formulation is available at the Chilean market that fulfills the requirements of pediatric patients on total parenteral nutrition. Therefore, adult formulations must be used. Aim: To prepare a parenteral aqueous multivitamin solution, to be used in pediatric patients. Material and methods: The solution was prepared, mixing vitamins according to their stability and compatibility, in a horizontal laminar flow hood. The quality control for this formulation at times zero and 30 days consisted of an organoleptic analysis, microbiologic and pyrogen controls and vitamin quantification. In addition, the effect of vitamin solution incorporation on the stability of total parenteral nutrition formulae was evaluated. The approximated production cost was calculated. Results: The ampoules did not show changes on the organoleptic characteristics. No bacterial contamination or pyrogens were detected. Total parenteral nutrition solutions were not modified after the incorporation of the vitamins. The vitamin solution was stable for one month at 4°C. Conclusions: The manufacture of this formulation results in significant savings, because it has a low manufacturing cost and fulfills pediatric requirements (Rev Méd Chile 2001; 129: 905-10)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.8 20012001-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000800009es10.4067/S0034-98872001000800009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Nutritional requirements Parenteral nutrition, total Pediatrics Vitamins
spellingShingle	Nutritional requirements Parenteral nutrition, total Pediatrics Vitamins Carreño G,Patricia Rosas E,Andrea Rojas E,Irene Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
description	Background: No intravenous multivitamin formulation is available at the Chilean market that fulfills the requirements of pediatric patients on total parenteral nutrition. Therefore, adult formulations must be used. Aim: To prepare a parenteral aqueous multivitamin solution, to be used in pediatric patients. Material and methods: The solution was prepared, mixing vitamins according to their stability and compatibility, in a horizontal laminar flow hood. The quality control for this formulation at times zero and 30 days consisted of an organoleptic analysis, microbiologic and pyrogen controls and vitamin quantification. In addition, the effect of vitamin solution incorporation on the stability of total parenteral nutrition formulae was evaluated. The approximated production cost was calculated. Results: The ampoules did not show changes on the organoleptic characteristics. No bacterial contamination or pyrogens were detected. Total parenteral nutrition solutions were not modified after the incorporation of the vitamins. The vitamin solution was stable for one month at 4°C. Conclusions: The manufacture of this formulation results in significant savings, because it has a low manufacturing cost and fulfills pediatric requirements (Rev Méd Chile 2001; 129: 905-10)
author	Carreño G,Patricia Rosas E,Andrea Rojas E,Irene
author_facet	Carreño G,Patricia Rosas E,Andrea Rojas E,Irene
author_sort	Carreño G,Patricia
title	Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
title_short	Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
title_full	Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
title_fullStr	Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
title_full_unstemmed	Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
title_sort	formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000800009
work_keys_str_mv	AT carrenogpatricia formulaciondeunamezclavitaminicaintravenosaparanutricionparenteraltotalpediatrica AT rosaseandrea formulaciondeunamezclavitaminicaintravenosaparanutricionparenteraltotalpediatrica AT rojaseirene formulaciondeunamezclavitaminicaintravenosaparanutricionparenteraltotalpediatrica
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Formulación de una mezcla vitamínica intravenosa para nutrición parenteral total pediátrica

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