El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos

Background: Clinical research stresses the need for evidence as a basis for setting research agendas. The extent to which current clinical research involves recent advances in biostatistics is not well known. Aim: This manuscript focuses on the use of interim analyses accumulating data in clinical t...

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Autores principales:	Muñoz N,Sergio R, Bangdiwala,Shrikant I
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Bibliometrics Meta-analysis Research design Statistics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900002
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spelling	oai:scielo:S0034-988720010009000022005-11-24El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicosMuñoz N,Sergio RBangdiwala,Shrikant I Bibliometrics Meta-analysis Research design Statistics Background: Clinical research stresses the need for evidence as a basis for setting research agendas. The extent to which current clinical research involves recent advances in biostatistics is not well known. Aim: This manuscript focuses on the use of interim analyses accumulating data in clinical trials. Material and Methods: A PubMed search was conducted for the period 1990-2000. Keywords used included interim analysis, alpha-spending function, and early termination, after subsetting to randomised controlled trials (RCT) that were multicenter since these particular studies are more likely to have external monitoring boards conducting interim analyses. Studies were grouped by clinical discipline and also by journals of high or low impact index. Results: Thirteen thousand two hundred eighty two articles with both RCT and multicenter were found. Of these, the interim analysis keyword yielded 879 articles, of which only 163 (19%) studies reported their methodology. The percentages varied by clinical discipline and by journal type. A 25% random sample of the articles were further reviewed to investigate the appropriateness of the interim analysis methods used. Discussion: Recent articles in the medical literature attempt to make the interim analysis methods more accessible to clinicians. However, further training of statisticians involved in clinical trials is needed as well (Rev Méd Chile 2001; 129: 983-8)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.9 20012001-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900002es10.4067/S0034-98872001000900002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bibliometrics Meta-analysis Research design Statistics
spellingShingle	Bibliometrics Meta-analysis Research design Statistics Muñoz N,Sergio R Bangdiwala,Shrikant I El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
description	Background: Clinical research stresses the need for evidence as a basis for setting research agendas. The extent to which current clinical research involves recent advances in biostatistics is not well known. Aim: This manuscript focuses on the use of interim analyses accumulating data in clinical trials. Material and Methods: A PubMed search was conducted for the period 1990-2000. Keywords used included interim analysis, alpha-spending function, and early termination, after subsetting to randomised controlled trials (RCT) that were multicenter since these particular studies are more likely to have external monitoring boards conducting interim analyses. Studies were grouped by clinical discipline and also by journals of high or low impact index. Results: Thirteen thousand two hundred eighty two articles with both RCT and multicenter were found. Of these, the interim analysis keyword yielded 879 articles, of which only 163 (19%) studies reported their methodology. The percentages varied by clinical discipline and by journal type. A 25% random sample of the articles were further reviewed to investigate the appropriateness of the interim analysis methods used. Discussion: Recent articles in the medical literature attempt to make the interim analysis methods more accessible to clinicians. However, further training of statisticians involved in clinical trials is needed as well (Rev Méd Chile 2001; 129: 983-8)
author	Muñoz N,Sergio R Bangdiwala,Shrikant I
author_facet	Muñoz N,Sergio R Bangdiwala,Shrikant I
author_sort	Muñoz N,Sergio R
title	El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
title_short	El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
title_full	El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
title_fullStr	El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
title_full_unstemmed	El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
title_sort	el uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900002
work_keys_str_mv	AT munoznsergior elusodemetodologiaestadisticaactualizadaenlainvestigacionbiomedicaelejemplodemetodologiaparaanalisisinterinoenensayosclinicos AT bangdiwalashrikanti elusodemetodologiaestadisticaactualizadaenlainvestigacionbiomedicaelejemplodemetodologiaparaanalisisinterinoenensayosclinicos
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El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos

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