Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro

Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt.The pathogenesis of CHE remains unclear but increased levels of ammonia are a basic feature. Several clinical and experimental observations support a role for manganese (Mn) in the path...

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Autores principales:	Miranda C,Marcelo, Caballero E,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Ammonia Hepatic encephalopathy Magnetic resonance imaging Manganes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900011
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spelling	oai:scielo:S0034-988720010009000112005-11-24Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebroMiranda C,MarceloCaballero E,Luis Ammonia Hepatic encephalopathy Magnetic resonance imaging Manganes Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt.The pathogenesis of CHE remains unclear but increased levels of ammonia are a basic feature. Several clinical and experimental observations support a role for manganese (Mn) in the pathogenesis of this disorder. Increased blood levels of Mn have been described in patients with CHE and this could lead to its accumulation on the basal ganglia and characteristic hyperintensities of basal ganglia as seen on magnetic resonance imaging (MRI) of the brain. We report on the clinical features and characteristic radiologic findings of a patient who presented with the neurologic syndrome of CHE and who had very high blood levels of Mn in the absence of an occupational exposure to this metal. Our report supports the hypothesis that Mn has a role in the pathogenesis of CHE and also suggests that brain MRI is a useful marker of the brain metabolic repercusion due to CHE (Rev Méd Chile 2001; 129: 1051-5info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.9 20012001-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900011es10.4067/S0034-98872001000900011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ammonia Hepatic encephalopathy Magnetic resonance imaging Manganes
spellingShingle	Ammonia Hepatic encephalopathy Magnetic resonance imaging Manganes Miranda C,Marcelo Caballero E,Luis Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
description	Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt.The pathogenesis of CHE remains unclear but increased levels of ammonia are a basic feature. Several clinical and experimental observations support a role for manganese (Mn) in the pathogenesis of this disorder. Increased blood levels of Mn have been described in patients with CHE and this could lead to its accumulation on the basal ganglia and characteristic hyperintensities of basal ganglia as seen on magnetic resonance imaging (MRI) of the brain. We report on the clinical features and characteristic radiologic findings of a patient who presented with the neurologic syndrome of CHE and who had very high blood levels of Mn in the absence of an occupational exposure to this metal. Our report supports the hypothesis that Mn has a role in the pathogenesis of CHE and also suggests that brain MRI is a useful marker of the brain metabolic repercusion due to CHE (Rev Méd Chile 2001; 129: 1051-5
author	Miranda C,Marcelo Caballero E,Luis
author_facet	Miranda C,Marcelo Caballero E,Luis
author_sort	Miranda C,Marcelo
title	Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
title_short	Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
title_full	Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
title_fullStr	Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
title_full_unstemmed	Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
title_sort	encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001000900011
work_keys_str_mv	AT mirandacmarcelo encefalopatiahepaticacronicaroldenivelessanguineoselevadosdemanganesoysurelacionconlesionesengangliosbasalesenlaresonanciamagneticanucleardecerebro AT caballeroeluis encefalopatiahepaticacronicaroldenivelessanguineoselevadosdemanganesoysurelacionconlesionesengangliosbasalesenlaresonanciamagneticanucleardecerebro
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Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro

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