Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos

Background: There is little information about the behavior of early gallbladder carcinoma. Aim: To report the clinical and pathological features of 196 patients with early gallbladder carcinoma. Material and methods: All patients with gallbladder cancer diagnosed between 1988 and 1997 were reviewed....

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Autores principales: Roa E,Iván, de Aretxabala U,Xabier, Araya O,Juan C, Villaseca H,Miguel, Roa S,Juan, Guzmán G,Pablo
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2001
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001000002
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spelling oai:scielo:S0034-988720010010000022005-11-14Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casosRoa E,Ivánde Aretxabala U,XabierAraya O,Juan CVillaseca H,MiguelRoa S,JuanGuzmán G,PabloBackground: There is little information about the behavior of early gallbladder carcinoma. Aim: To report the clinical and pathological features of 196 patients with early gallbladder carcinoma. Material and methods: All patients with gallbladder cancer diagnosed between 1988 and 1997 were reviewed. In 703 of 829 patients, there was information about clinical features and follow up, and were included in this study. All gallbladders were subjected to a complete mapping. When neoplastic cells involved only the mucosa or muscular layer, the tumors were considered as early. Results: One hundred ninety six patients had an early carcinoma (161 women, aged 57.5 years and 35 male, aged 63.4 years). One hundred twenty eight tumors were located in the mucosa and 68 in the muscular layer. Patients with tumors involving the mucosa were younger than those with tumors involving the muscular layer. All tumors were adenocarcinomas, 66% were well differentiated and 32% moderately differentiated. Tumors were not visible macroscopically in 132 cases. Five and 10 years survival was 92%. Subjects of less than 40 years old had a 100% survival at 5 years. A hepatic and lymph node resection was done in 12 patients with tumors infiltrating the muscular layer but in only one, the tumor infiltrated the liver. No difference in survival was observed when a simple cholecystectomy or radical surgery was done. Conclusions: Nearly 25% of gallbladder carcinomas can be classified as early and its diagnosis requires a directed studyinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.10 20012001-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001000002es10.4067/S0034-98872001001000002
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
description Background: There is little information about the behavior of early gallbladder carcinoma. Aim: To report the clinical and pathological features of 196 patients with early gallbladder carcinoma. Material and methods: All patients with gallbladder cancer diagnosed between 1988 and 1997 were reviewed. In 703 of 829 patients, there was information about clinical features and follow up, and were included in this study. All gallbladders were subjected to a complete mapping. When neoplastic cells involved only the mucosa or muscular layer, the tumors were considered as early. Results: One hundred ninety six patients had an early carcinoma (161 women, aged 57.5 years and 35 male, aged 63.4 years). One hundred twenty eight tumors were located in the mucosa and 68 in the muscular layer. Patients with tumors involving the mucosa were younger than those with tumors involving the muscular layer. All tumors were adenocarcinomas, 66% were well differentiated and 32% moderately differentiated. Tumors were not visible macroscopically in 132 cases. Five and 10 years survival was 92%. Subjects of less than 40 years old had a 100% survival at 5 years. A hepatic and lymph node resection was done in 12 patients with tumors infiltrating the muscular layer but in only one, the tumor infiltrated the liver. No difference in survival was observed when a simple cholecystectomy or radical surgery was done. Conclusions: Nearly 25% of gallbladder carcinomas can be classified as early and its diagnosis requires a directed study
author Roa E,Iván
de Aretxabala U,Xabier
Araya O,Juan C
Villaseca H,Miguel
Roa S,Juan
Guzmán G,Pablo
spellingShingle Roa E,Iván
de Aretxabala U,Xabier
Araya O,Juan C
Villaseca H,Miguel
Roa S,Juan
Guzmán G,Pablo
Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
author_facet Roa E,Iván
de Aretxabala U,Xabier
Araya O,Juan C
Villaseca H,Miguel
Roa S,Juan
Guzmán G,Pablo
author_sort Roa E,Iván
title Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
title_short Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
title_full Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
title_fullStr Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
title_full_unstemmed Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
title_sort carcinoma incipiente de la vesícula biliar: estudio clínico-patológico y pronóstico de 196 casos
publisher Sociedad Médica de Santiago
publishDate 2001
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001000002
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