Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años

Background: Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done. Aim: To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension. Mate...

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Autores principales:	Román A,Oscar, Cuevas,Gerardo, Badilla S,Marta, Valenzuela C,María Angélica, Cumsille G,Francisco, Valverde F,Luis, González M,Alejandra, Pulgar SM,María, Pino V,Claudia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Antihypertensive agents Hypertension Risk factors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100004
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spelling	oai:scielo:S0034-988720010011000042002-06-12Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 añosRomán A,OscarCuevas,GerardoBadilla S,MartaValenzuela C,María AngélicaCumsille G,FranciscoValverde F,LuisGonzález M,AlejandraPulgar SM,MaríaPino V,Claudia Antihypertensive agents Hypertension Risk factors Background: Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done. Aim: To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension. Material and methods: A cohort of 1.072 treated patients with essential hypertension was followed for a period up to 25 years. Four hundred eighty six were men and 586 were women, age ranged from 31 to 70 years. At entry, 56% of subjects did not have any organic complications associated to hypertension (stage I WHO criteria), 30% had mild alterations (Stage II) and 14% had major complications (myocardial infarction, stroke, heart failure or renal failure). Likewise, 43.8% had mild, 14.5%, moderate and 41.7%, severe hypertension. Patients were treated with monotherapy or combined therapy based on diuretics, beta blockers, calcium antagonists and angiotensin converting enzyme inhibitors. Goal of therapy was 140/90 mm Hg. Risk factors associated diseases and complications were registered carefully. Causes of death were obtained from hospital records and death certificates. Mortality was analyzed using life tables (intention to treat method included). Results: Blood pressure dropped significantly during follow up from a mean of 182/110 to 154/92 mm Hg. During follow up, 143 patients died and 429 complications (lethal or non lethal) were recorded. Twenty four percent of patients smoked, 24% reported alcohol intake, 56% had hypercholesterolemia, 11% were obese, 13% had diabetes and 3% had gout. The proportional hazard model showed that the existence of previous complications, the presence of more than 3 risk factors, and age over 60 and mean systolic and diastolic pressure during therapy, were independent and significant risk factors for mortality. Conclusions: The incidence of risk factors among our hypertensive patients is very similar to that of other national or international cohorts (Rev Méd Chile 2001; 129: 1253-61)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.11 20012001-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100004es10.4067/S0034-98872001001100004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antihypertensive agents Hypertension Risk factors
spellingShingle	Antihypertensive agents Hypertension Risk factors Román A,Oscar Cuevas,Gerardo Badilla S,Marta Valenzuela C,María Angélica Cumsille G,Francisco Valverde F,Luis González M,Alejandra Pulgar SM,María Pino V,Claudia Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
description	Background: Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done. Aim: To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension. Material and methods: A cohort of 1.072 treated patients with essential hypertension was followed for a period up to 25 years. Four hundred eighty six were men and 586 were women, age ranged from 31 to 70 years. At entry, 56% of subjects did not have any organic complications associated to hypertension (stage I WHO criteria), 30% had mild alterations (Stage II) and 14% had major complications (myocardial infarction, stroke, heart failure or renal failure). Likewise, 43.8% had mild, 14.5%, moderate and 41.7%, severe hypertension. Patients were treated with monotherapy or combined therapy based on diuretics, beta blockers, calcium antagonists and angiotensin converting enzyme inhibitors. Goal of therapy was 140/90 mm Hg. Risk factors associated diseases and complications were registered carefully. Causes of death were obtained from hospital records and death certificates. Mortality was analyzed using life tables (intention to treat method included). Results: Blood pressure dropped significantly during follow up from a mean of 182/110 to 154/92 mm Hg. During follow up, 143 patients died and 429 complications (lethal or non lethal) were recorded. Twenty four percent of patients smoked, 24% reported alcohol intake, 56% had hypercholesterolemia, 11% were obese, 13% had diabetes and 3% had gout. The proportional hazard model showed that the existence of previous complications, the presence of more than 3 risk factors, and age over 60 and mean systolic and diastolic pressure during therapy, were independent and significant risk factors for mortality. Conclusions: The incidence of risk factors among our hypertensive patients is very similar to that of other national or international cohorts (Rev Méd Chile 2001; 129: 1253-61)
author	Román A,Oscar Cuevas,Gerardo Badilla S,Marta Valenzuela C,María Angélica Cumsille G,Francisco Valverde F,Luis González M,Alejandra Pulgar SM,María Pino V,Claudia
author_facet	Román A,Oscar Cuevas,Gerardo Badilla S,Marta Valenzuela C,María Angélica Cumsille G,Francisco Valverde F,Luis González M,Alejandra Pulgar SM,María Pino V,Claudia
author_sort	Román A,Oscar
title	Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
title_short	Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
title_full	Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
title_fullStr	Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
title_full_unstemmed	Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
title_sort	factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100004
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Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 años

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