Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald

The Friedewald formula is used to estimate cholesterol of low density lipoprotein (LDL) from total cholesterol (CT), cholesterol of high density lipoprotein (HDL) and triglycerides (TG), but there are doubts about its precision. Aim: To compare Friedewald formula and regression analysis for the calc...

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Autores principales:	Eblen-Zajjur,Antonio, Eblen-Zajjur,Marta
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2001
Materias:	Hypercholesterolemia Lipoproteins, HDL cholesterol Lipoproteins, LDL cholesterol Triglycerides
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100005
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spelling	oai:scielo:S0034-988720010011000052002-06-12Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de FriedewaldEblen-Zajjur,AntonioEblen-Zajjur,Marta Hypercholesterolemia Lipoproteins, HDL cholesterol Lipoproteins, LDL cholesterol Triglycerides The Friedewald formula is used to estimate cholesterol of low density lipoprotein (LDL) from total cholesterol (CT), cholesterol of high density lipoprotein (HDL) and triglycerides (TG), but there are doubts about its precision. Aim: To compare Friedewald formula and regression analysis for the calculation of LDL cholesterol. Material and methods: One hundred and fifty plasma samples from asymptomatic adults (aged 47.7 ± 13 years, 50.6% male) were analyzed. CT, HDL, LDL and TG were determined by enzymatic methods. Friedewald formula (LDLc=CT-HDL-(TG/5)) and multiple regression analysis were applied to estimate LDL concentration. Results: Mean total cholesterol was 175.3 ± 39.7 mg/dl, HDL cholesterol was 35.57 ± 0.8 mg/dl and TG was 128.4 ± 65.4 mg/dl. Mean values for LDL cholesterol were significantly higher than those estimated by the Friedewald formula (136.4 ± 37.9 mg/dl and 114.1 ± 37.4 mg/dl respectively, p<0.001) with a mean underestimation of 16.4 ± 11.7%. LDL cholesterol values were directly proportional to TG concentration. Multiple regression analysis (LDLr=-14.376 + (age x 0.198) + (CT x 0.949) + (HDL x -0.474) + (TG x -0.064) showed no statistical differences with those obtained by the enzymatic method. Conclusions: These results confirm the underestimation of LDL concentration by the Friedewald formula despite normal range of TG concentration. A multiple regression analysis should be used to estimate LDL concentration with precision (Rev Méd Chile 2001; 129: 1263-70)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.129 n.11 20012001-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100005es10.4067/S0034-98872001001100005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hypercholesterolemia Lipoproteins, HDL cholesterol Lipoproteins, LDL cholesterol Triglycerides
spellingShingle	Hypercholesterolemia Lipoproteins, HDL cholesterol Lipoproteins, LDL cholesterol Triglycerides Eblen-Zajjur,Antonio Eblen-Zajjur,Marta Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
description	The Friedewald formula is used to estimate cholesterol of low density lipoprotein (LDL) from total cholesterol (CT), cholesterol of high density lipoprotein (HDL) and triglycerides (TG), but there are doubts about its precision. Aim: To compare Friedewald formula and regression analysis for the calculation of LDL cholesterol. Material and methods: One hundred and fifty plasma samples from asymptomatic adults (aged 47.7 ± 13 years, 50.6% male) were analyzed. CT, HDL, LDL and TG were determined by enzymatic methods. Friedewald formula (LDLc=CT-HDL-(TG/5)) and multiple regression analysis were applied to estimate LDL concentration. Results: Mean total cholesterol was 175.3 ± 39.7 mg/dl, HDL cholesterol was 35.57 ± 0.8 mg/dl and TG was 128.4 ± 65.4 mg/dl. Mean values for LDL cholesterol were significantly higher than those estimated by the Friedewald formula (136.4 ± 37.9 mg/dl and 114.1 ± 37.4 mg/dl respectively, p<0.001) with a mean underestimation of 16.4 ± 11.7%. LDL cholesterol values were directly proportional to TG concentration. Multiple regression analysis (LDLr=-14.376 + (age x 0.198) + (CT x 0.949) + (HDL x -0.474) + (TG x -0.064) showed no statistical differences with those obtained by the enzymatic method. Conclusions: These results confirm the underestimation of LDL concentration by the Friedewald formula despite normal range of TG concentration. A multiple regression analysis should be used to estimate LDL concentration with precision (Rev Méd Chile 2001; 129: 1263-70)
author	Eblen-Zajjur,Antonio Eblen-Zajjur,Marta
author_facet	Eblen-Zajjur,Antonio Eblen-Zajjur,Marta
author_sort	Eblen-Zajjur,Antonio
title	Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
title_short	Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
title_full	Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
title_fullStr	Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
title_full_unstemmed	Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald
title_sort	cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de friedewald
publisher	Sociedad Médica de Santiago
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872001001100005
work_keys_str_mv	AT eblenzajjurantonio calculodelaconcentraciondecolesteroldelalipoproteinadebajadensidadanalisisderegresionversusformuladefriedewald AT eblenzajjurmarta calculodelaconcentraciondecolesteroldelalipoproteinadebajadensidadanalisisderegresionversusformuladefriedewald
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Cálculo de la concentración de colesterol de la lipoproteína de baja densidad: análisis de regresión versus fórmula de Friedewald

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