Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia

Background: Helicobacter pylori is recognized as an etiologic agent of several gastric diseases. Bacterial genotypes have been related to clinical outcome in several populations. Aim: To compare cagA, vacA and iceA genotypes of Colombian isolates from patients with several gastrointestinal diseases,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cittelly P,Diana M, Huertas,Mónica G, Martínez,Julián D, Oliveros,Ricardo, Posso,Héctor, Bravo,María Mercedes, Orozco D,Oscar
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Gastritis, atrophic Gastritis, hypertrophic Helicobacter pylori Neoplasms, glandular and epithelial
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872002000200003
record_format	dspace
spelling	oai:scielo:S0034-988720020002000032014-08-20Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en ColombiaCittelly P,Diana MHuertas,Mónica GMartínez,Julián DOliveros,RicardoPosso,HéctorBravo,María MercedesOrozco D,Oscar Gastritis, atrophic Gastritis, hypertrophic Helicobacter pylori Neoplasms, glandular and epithelial Background: Helicobacter pylori is recognized as an etiologic agent of several gastric diseases. Bacterial genotypes have been related to clinical outcome in several populations. Aim: To compare cagA, vacA and iceA genotypes of Colombian isolates from patients with several gastrointestinal diseases, including gastric cancer. Material and methods: We used polymerase chain reactions to amplify vacA, cagA and iceA genes of 137 H pylori isolates coming from 26 patients with gastric cancer (GC), 34 with peptic ulcer (PU), 19 with intestinal metaplasia (IM), 23 with atrophic gastritis (AG) and 35 with non atrophic gastritis (NAG). Results: vacA s1-m1, cagA+, iceA+ were the most frequently found genotypes. vacA s1 and m1 subtypes were found in 92 (67%) and 82 (60%) cases respectively. Sixty three percent were cagA+ and 85% were iceA+. There was a lower prevalence of s1 allele in cases of NAG (43%), compared with GC, PU and IM (81%, 77% and 81% prevalence, respectively, p <0.01). Isolates from NAG also showed a low frequency of vacA m1 subtype (40%) compared with GC or IM (81% and 84% respectively, p <0.01). The prevalence of cagA+ strains was significantly higher in GC patients (80%) than in NAG patients (51.4%, p <0.01). No differences in the frequency of vacA s1a, s1b and iceA subtypes, were observed. Conclusions: A lower frequency of cytotoxic H pylori genotypes such as cagA and vacA s1m1 and a higher frequency of non cytotoxic genotypes, was observed in patients with NAG, when compared to patients with GC or PU. These results suggest that even in Colombia, vacA and cagA could be used as markers of increased virulence (Rev Méd Chile 2002; 130: 143-51)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.2 20022002-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200003es10.4067/S0034-98872002000200003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gastritis, atrophic Gastritis, hypertrophic Helicobacter pylori Neoplasms, glandular and epithelial
spellingShingle	Gastritis, atrophic Gastritis, hypertrophic Helicobacter pylori Neoplasms, glandular and epithelial Cittelly P,Diana M Huertas,Mónica G Martínez,Julián D Oliveros,Ricardo Posso,Héctor Bravo,María Mercedes Orozco D,Oscar Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
description	Background: Helicobacter pylori is recognized as an etiologic agent of several gastric diseases. Bacterial genotypes have been related to clinical outcome in several populations. Aim: To compare cagA, vacA and iceA genotypes of Colombian isolates from patients with several gastrointestinal diseases, including gastric cancer. Material and methods: We used polymerase chain reactions to amplify vacA, cagA and iceA genes of 137 H pylori isolates coming from 26 patients with gastric cancer (GC), 34 with peptic ulcer (PU), 19 with intestinal metaplasia (IM), 23 with atrophic gastritis (AG) and 35 with non atrophic gastritis (NAG). Results: vacA s1-m1, cagA+, iceA+ were the most frequently found genotypes. vacA s1 and m1 subtypes were found in 92 (67%) and 82 (60%) cases respectively. Sixty three percent were cagA+ and 85% were iceA+. There was a lower prevalence of s1 allele in cases of NAG (43%), compared with GC, PU and IM (81%, 77% and 81% prevalence, respectively, p <0.01). Isolates from NAG also showed a low frequency of vacA m1 subtype (40%) compared with GC or IM (81% and 84% respectively, p <0.01). The prevalence of cagA+ strains was significantly higher in GC patients (80%) than in NAG patients (51.4%, p <0.01). No differences in the frequency of vacA s1a, s1b and iceA subtypes, were observed. Conclusions: A lower frequency of cytotoxic H pylori genotypes such as cagA and vacA s1m1 and a higher frequency of non cytotoxic genotypes, was observed in patients with NAG, when compared to patients with GC or PU. These results suggest that even in Colombia, vacA and cagA could be used as markers of increased virulence (Rev Méd Chile 2002; 130: 143-51)
author	Cittelly P,Diana M Huertas,Mónica G Martínez,Julián D Oliveros,Ricardo Posso,Héctor Bravo,María Mercedes Orozco D,Oscar
author_facet	Cittelly P,Diana M Huertas,Mónica G Martínez,Julián D Oliveros,Ricardo Posso,Héctor Bravo,María Mercedes Orozco D,Oscar
author_sort	Cittelly P,Diana M
title	Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
title_short	Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
title_full	Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
title_fullStr	Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
title_full_unstemmed	Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia
title_sort	los genotipos de helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en colombia
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200003
work_keys_str_mv	AT cittellypdianam losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT huertasmonicag losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT martinezjuliand losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT oliverosricardo losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT possohector losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT bravomariamercedes losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia AT orozcodoscar losgenotiposdehelicobacterpyloriengastritisnoatroficadifierendelosencontradosenulcerapepticalesionespremalignasycancergastricoencolombia
_version_	1718436013196443648

Los genotipos de Helicobacter pylori en gastritis no atrófica difieren de los encontrados en úlcera péptica, lesiones premalignas y cáncer gástrico en Colombia

Ejemplares similares