Hipertensión pulmonar y embarazo

A 36 year old woman, with an 18 year history of syncope, became pregnant shortly after a cardiac catheterization demonstrated a high pulmonary arterial pressure and resistance and a low cardiac output. During pregnancy she remained stable at NYHA FC III, on nifedipine, apresoline, isosorbide, aspiri...

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Autores principales:	Valdés S,Gloria, Matthei F,Robert, Fernández V,María Soledad, Schacht F,Carmen, Corthorn H,Jenny, Germaín A,Alfredo M
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Hypertension, pulmonary Pregnancy complications, cardiovascular Pulmonary artery
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200010
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spelling	oai:scielo:S0034-988720020002000102014-08-20Hipertensión pulmonar y embarazoValdés S,GloriaMatthei F,RobertFernández V,María SoledadSchacht F,CarmenCorthorn H,JennyGermaín A,Alfredo M Hypertension, pulmonary Pregnancy complications, cardiovascular Pulmonary artery A 36 year old woman, with an 18 year history of syncope, became pregnant shortly after a cardiac catheterization demonstrated a high pulmonary arterial pressure and resistance and a low cardiac output. During pregnancy she remained stable at NYHA FC III, on nifedipine, apresoline, isosorbide, aspirin and bed rest. At 28 weeks, catheterization showed a decreased pulmonary pressure and an increased cardiac output. At 38 weeks, she was submitted to an elective caesarean section, and delivered a healthy newborn of 2820 g. After 5 months, her catheterization showed a pulmonary artery pressure similar to the pre-pregnancy study. Her condition deteriorated, leading to death 10 months later. Urinary 6-keto-PGF1∂, nitrates/nitrites, kallikrein and angiotensin-(1-7) were increased from 13 to 33 weeks, to drop in week 35 of pregnancy. The safe maternal and fetal outcome, and the intragestational hemodynamic improvement are attributed to a close multidisciplinary surveillance, and to the effects of the endogenous vasodilators of pregnancy on the reversible component of the pulmonary hypertension. Reports in the literature show a decrease in maternal mortality rate, from 56% for the period previous to 1963, to 34 and 30% for those spanning between 1978-1996 y 1997-2001 respectively (Rev Méd Chile 2002; 130: 201-8)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.2 20022002-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200010es10.4067/S0034-98872002000200010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hypertension, pulmonary Pregnancy complications, cardiovascular Pulmonary artery
spellingShingle	Hypertension, pulmonary Pregnancy complications, cardiovascular Pulmonary artery Valdés S,Gloria Matthei F,Robert Fernández V,María Soledad Schacht F,Carmen Corthorn H,Jenny Germaín A,Alfredo M Hipertensión pulmonar y embarazo
description	A 36 year old woman, with an 18 year history of syncope, became pregnant shortly after a cardiac catheterization demonstrated a high pulmonary arterial pressure and resistance and a low cardiac output. During pregnancy she remained stable at NYHA FC III, on nifedipine, apresoline, isosorbide, aspirin and bed rest. At 28 weeks, catheterization showed a decreased pulmonary pressure and an increased cardiac output. At 38 weeks, she was submitted to an elective caesarean section, and delivered a healthy newborn of 2820 g. After 5 months, her catheterization showed a pulmonary artery pressure similar to the pre-pregnancy study. Her condition deteriorated, leading to death 10 months later. Urinary 6-keto-PGF1∂, nitrates/nitrites, kallikrein and angiotensin-(1-7) were increased from 13 to 33 weeks, to drop in week 35 of pregnancy. The safe maternal and fetal outcome, and the intragestational hemodynamic improvement are attributed to a close multidisciplinary surveillance, and to the effects of the endogenous vasodilators of pregnancy on the reversible component of the pulmonary hypertension. Reports in the literature show a decrease in maternal mortality rate, from 56% for the period previous to 1963, to 34 and 30% for those spanning between 1978-1996 y 1997-2001 respectively (Rev Méd Chile 2002; 130: 201-8)
author	Valdés S,Gloria Matthei F,Robert Fernández V,María Soledad Schacht F,Carmen Corthorn H,Jenny Germaín A,Alfredo M
author_facet	Valdés S,Gloria Matthei F,Robert Fernández V,María Soledad Schacht F,Carmen Corthorn H,Jenny Germaín A,Alfredo M
author_sort	Valdés S,Gloria
title	Hipertensión pulmonar y embarazo
title_short	Hipertensión pulmonar y embarazo
title_full	Hipertensión pulmonar y embarazo
title_fullStr	Hipertensión pulmonar y embarazo
title_full_unstemmed	Hipertensión pulmonar y embarazo
title_sort	hipertensión pulmonar y embarazo
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000200010
work_keys_str_mv	AT valdessgloria hipertensionpulmonaryembarazo AT mattheifrobert hipertensionpulmonaryembarazo AT fernandezvmariasoledad hipertensionpulmonaryembarazo AT schachtfcarmen hipertensionpulmonaryembarazo AT corthornhjenny hipertensionpulmonaryembarazo AT germainaalfredom hipertensionpulmonaryembarazo
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Hipertensión pulmonar y embarazo

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