Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile

Background: The chemical stability of a pharmaceutical product depends, among other factors, on environmental factors during transport, storage and manipulation of the product. Aim: To study the chemical stability of acetylsalicylic acid (AAS) tablets during ten months of storage in five pharmacies...

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Autores principales:	Mennickent C,Sigrid, Yates K,Tamara, Vega H,Mario, Godoy M,C Gloria, Saelzer F,Roberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Aspirin High performance thin layer chromatography Drug stability Drug delivery systems Drug storage
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000400008
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spelling	oai:scielo:S0034-988720020004000082003-01-24Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, ChileMennickent C,SigridYates K,TamaraVega H,MarioGodoy M,C GloriaSaelzer F,Roberto Aspirin High performance thin layer chromatography Drug stability Drug delivery systems Drug storage Background: The chemical stability of a pharmaceutical product depends, among other factors, on environmental factors during transport, storage and manipulation of the product. Aim: To study the chemical stability of acetylsalicylic acid (AAS) tablets during ten months of storage in five pharmacies of Concepción, Chile. Material and methods: Tablets were randomly collected at the beginning of the study and at the third, sixth and tenth month. Quantitative analyses of AAS tablets was carried out by instrumental thin layer chromatography (HPTLC). Results: AAS in tablets was between 99 and 109% at the beginning of the study, between 76 and 110% at three months, between 71% and 112% at six months and between 86 and 110% at ten months of storage. Conclusions: There was a progressive decrease in the content of acetylsalicylic acid in tables during storage, but it remained between the limits accepted by the United States Pharmacopoeia (USP) (90-110%) (Rev Méd Chile 2002; 130: 409-415)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.4 20022002-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000400008es10.4067/S0034-98872002000400008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aspirin High performance thin layer chromatography Drug stability Drug delivery systems Drug storage
spellingShingle	Aspirin High performance thin layer chromatography Drug stability Drug delivery systems Drug storage Mennickent C,Sigrid Yates K,Tamara Vega H,Mario Godoy M,C Gloria Saelzer F,Roberto Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
description	Background: The chemical stability of a pharmaceutical product depends, among other factors, on environmental factors during transport, storage and manipulation of the product. Aim: To study the chemical stability of acetylsalicylic acid (AAS) tablets during ten months of storage in five pharmacies of Concepción, Chile. Material and methods: Tablets were randomly collected at the beginning of the study and at the third, sixth and tenth month. Quantitative analyses of AAS tablets was carried out by instrumental thin layer chromatography (HPTLC). Results: AAS in tablets was between 99 and 109% at the beginning of the study, between 76 and 110% at three months, between 71% and 112% at six months and between 86 and 110% at ten months of storage. Conclusions: There was a progressive decrease in the content of acetylsalicylic acid in tables during storage, but it remained between the limits accepted by the United States Pharmacopoeia (USP) (90-110%) (Rev Méd Chile 2002; 130: 409-415)
author	Mennickent C,Sigrid Yates K,Tamara Vega H,Mario Godoy M,C Gloria Saelzer F,Roberto
author_facet	Mennickent C,Sigrid Yates K,Tamara Vega H,Mario Godoy M,C Gloria Saelzer F,Roberto
author_sort	Mennickent C,Sigrid
title	Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
title_short	Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
title_full	Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
title_fullStr	Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
title_full_unstemmed	Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile
title_sort	estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de concepción, chile
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000400008
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Estudio de la estabilidad química de comprimidos de ácido acetilsalicílico mediante un control de estanterías en farmacias de Concepción, Chile

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