Alcohol-induced liver disease: From molecular damage to treatment

Although the interaction between alcohol and the liver has been the subject of intensive investigation since many years, several uncertainties remain to be solved. Good examples of what we need to learn are: The real number of patients with alcohol-induced liver disease (AILD), the dose of alcohol &...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fernández Checa,José C, Bellentani,Stefano, Tiribelli,Claudio
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Alcohol dehydrogenase Alcohol-induced disorders Cytokines Liver diseases, alcoholic Tumor necrosis factor
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000600013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872002000600013
record_format	dspace
spelling	oai:scielo:S0034-988720020006000132014-08-20Alcohol-induced liver disease: From molecular damage to treatmentFernández Checa,José CBellentani,StefanoTiribelli,Claudio Alcohol dehydrogenase Alcohol-induced disorders Cytokines Liver diseases, alcoholic Tumor necrosis factor Although the interaction between alcohol and the liver has been the subject of intensive investigation since many years, several uncertainties remain to be solved. Good examples of what we need to learn are: The real number of patients with alcohol-induced liver disease (AILD), the dose of alcohol "safe" for the liver, the genetic predisposition to the damage or, on the other side of the coin, protecting from the damage. Rather recently, however, part of these questions started to be clarified, thus permitting a better definition of the role of each of these factors in AILD. In parallel to the clinical approach to AILD, the unveiling of the molecular and biochemical mechanisms involved in AILD has progressed and proved to be important in both a better understanding of the disease and, more important, in a more rational treatment of these disorders. This review will focus on what we currently know of AILD in clinical, biochemical and molecular terms and what we need to address in the future (Rev Med Chile 2002; 130: 681-690).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.6 20022002-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000600013en10.4067/S0034-98872002000600013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alcohol dehydrogenase Alcohol-induced disorders Cytokines Liver diseases, alcoholic Tumor necrosis factor
spellingShingle	Alcohol dehydrogenase Alcohol-induced disorders Cytokines Liver diseases, alcoholic Tumor necrosis factor Fernández Checa,José C Bellentani,Stefano Tiribelli,Claudio Alcohol-induced liver disease: From molecular damage to treatment
description	Although the interaction between alcohol and the liver has been the subject of intensive investigation since many years, several uncertainties remain to be solved. Good examples of what we need to learn are: The real number of patients with alcohol-induced liver disease (AILD), the dose of alcohol "safe" for the liver, the genetic predisposition to the damage or, on the other side of the coin, protecting from the damage. Rather recently, however, part of these questions started to be clarified, thus permitting a better definition of the role of each of these factors in AILD. In parallel to the clinical approach to AILD, the unveiling of the molecular and biochemical mechanisms involved in AILD has progressed and proved to be important in both a better understanding of the disease and, more important, in a more rational treatment of these disorders. This review will focus on what we currently know of AILD in clinical, biochemical and molecular terms and what we need to address in the future (Rev Med Chile 2002; 130: 681-690).
author	Fernández Checa,José C Bellentani,Stefano Tiribelli,Claudio
author_facet	Fernández Checa,José C Bellentani,Stefano Tiribelli,Claudio
author_sort	Fernández Checa,José C
title	Alcohol-induced liver disease: From molecular damage to treatment
title_short	Alcohol-induced liver disease: From molecular damage to treatment
title_full	Alcohol-induced liver disease: From molecular damage to treatment
title_fullStr	Alcohol-induced liver disease: From molecular damage to treatment
title_full_unstemmed	Alcohol-induced liver disease: From molecular damage to treatment
title_sort	alcohol-induced liver disease: from molecular damage to treatment
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000600013
work_keys_str_mv	AT fernandezchecajosec alcoholinducedliverdiseasefrommoleculardamagetotreatment AT bellentanistefano alcoholinducedliverdiseasefrommoleculardamagetotreatment AT tiribelliclaudio alcoholinducedliverdiseasefrommoleculardamagetotreatment
_version_	1718436038866632704

Alcohol-induced liver disease: From molecular damage to treatment

Ejemplares similares