Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento

Background: There is some information about wheeze characteristics in infants, however it is not clear whether the different wheeze patterns relates to prognosis and evolution during the first two years of life. Objectives: To characterize wheezing and spectral pattern of lung sounds in infants with...

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Autores principales:	Sánchez D,Ignacio, Navarro M,Héctor, Bertrand N,Pablo, Alvarez G,Cecilia, Lisboa B,Carmen
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Infant care Lung diseases, obstructive Lung volume measurements Respiratory sounds
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000700007
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spelling	oai:scielo:S0034-988720020007000072014-08-20Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimientoSánchez D,IgnacioNavarro M,HéctorBertrand N,PabloAlvarez G,CeciliaLisboa B,Carmen Infant care Lung diseases, obstructive Lung volume measurements Respiratory sounds Background: There is some information about wheeze characteristics in infants, however it is not clear whether the different wheeze patterns relates to prognosis and evolution during the first two years of life. Objectives: To characterize wheezing and spectral pattern of lung sounds in infants with acute bronchiolitis (AB) and in infants with recurrent wheeze (RW) as well as to compare these parameters with the clinical evolution 2 years after admission. Methods: Seventy six AB infants (48 boys), aged 5.5±0.7 months (mean ± SD), 62 RSV (+) and 32 RW infants (20 boys), aged 11.4±2 months were studied during the first week of admission at the hospital. Patients were studied during spontaneous sleep, breathing with a face mask connected to a pneumotachograph at flows of 0.1±0.02L/s. Sounds were registered at baseline and 20 minutes after salbutamol using 2 contact sensors placed at both lower lobes levels. Signals were low-pass filtered, amplified and a Fourier analysis was applied to sounds within a target flow range. Spectral analysis was done between 100 and 1000 HZ. Results: In 40/76 (53%) AB vs 30/34 (88%) RW sinusoidal wheezing (p <0.01; chi2) were observed and a positive bronchodilator response was obtained in 37/76 (49%) AB vs 32/34 (94%) RW (p <0.01; chi²). Patients with sinusoidal wheezing (s-w) had more wheezing episodes in follow-up, 26/40 vs 8/36 in complex wheezing (c-w), (p <0.01: chi²) and 30/34 in RW (p <0.01; chi²). IgE values at 18 months were higher in s-w compared to c-w (63±7 vs 24±5 Iu/mL (p <0.01) and 96±11 Iu/mL in RW (p <0.01). Conclusions: a) Wheezing characteristics in acute bronchiolitis vs recurrent wheezing are different; b) Bronchodilator response relates to wheeze characteristics and c) Higher IgE and more recurrent wheezing episodes are seen in acute bronchiolitis with sinusoidal wheezing. These findings suggest that lung sounds analysis is useful in assessing wheezy patients and have a value to identify infants on risk of developing asthma (Rev Méd Chile 2002; 130: 760-7)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.7 20022002-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000700007es10.4067/S0034-98872002000700007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Infant care Lung diseases, obstructive Lung volume measurements Respiratory sounds
spellingShingle	Infant care Lung diseases, obstructive Lung volume measurements Respiratory sounds Sánchez D,Ignacio Navarro M,Héctor Bertrand N,Pablo Alvarez G,Cecilia Lisboa B,Carmen Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
description	Background: There is some information about wheeze characteristics in infants, however it is not clear whether the different wheeze patterns relates to prognosis and evolution during the first two years of life. Objectives: To characterize wheezing and spectral pattern of lung sounds in infants with acute bronchiolitis (AB) and in infants with recurrent wheeze (RW) as well as to compare these parameters with the clinical evolution 2 years after admission. Methods: Seventy six AB infants (48 boys), aged 5.5±0.7 months (mean ± SD), 62 RSV (+) and 32 RW infants (20 boys), aged 11.4±2 months were studied during the first week of admission at the hospital. Patients were studied during spontaneous sleep, breathing with a face mask connected to a pneumotachograph at flows of 0.1±0.02L/s. Sounds were registered at baseline and 20 minutes after salbutamol using 2 contact sensors placed at both lower lobes levels. Signals were low-pass filtered, amplified and a Fourier analysis was applied to sounds within a target flow range. Spectral analysis was done between 100 and 1000 HZ. Results: In 40/76 (53%) AB vs 30/34 (88%) RW sinusoidal wheezing (p <0.01; chi2) were observed and a positive bronchodilator response was obtained in 37/76 (49%) AB vs 32/34 (94%) RW (p <0.01; chi²). Patients with sinusoidal wheezing (s-w) had more wheezing episodes in follow-up, 26/40 vs 8/36 in complex wheezing (c-w), (p <0.01: chi²) and 30/34 in RW (p <0.01; chi²). IgE values at 18 months were higher in s-w compared to c-w (63±7 vs 24±5 Iu/mL (p <0.01) and 96±11 Iu/mL in RW (p <0.01). Conclusions: a) Wheezing characteristics in acute bronchiolitis vs recurrent wheezing are different; b) Bronchodilator response relates to wheeze characteristics and c) Higher IgE and more recurrent wheezing episodes are seen in acute bronchiolitis with sinusoidal wheezing. These findings suggest that lung sounds analysis is useful in assessing wheezy patients and have a value to identify infants on risk of developing asthma (Rev Méd Chile 2002; 130: 760-7)
author	Sánchez D,Ignacio Navarro M,Héctor Bertrand N,Pablo Alvarez G,Cecilia Lisboa B,Carmen
author_facet	Sánchez D,Ignacio Navarro M,Héctor Bertrand N,Pablo Alvarez G,Cecilia Lisboa B,Carmen
author_sort	Sánchez D,Ignacio
title	Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
title_short	Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
title_full	Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
title_fullStr	Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
title_full_unstemmed	Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento
title_sort	análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: estudio de seguimiento
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000700007
work_keys_str_mv	AT sanchezdignacio analisisacusticodelassibilanciasenlactantesconobstruccionbronquialagudaestudiodeseguimiento AT navarromhector analisisacusticodelassibilanciasenlactantesconobstruccionbronquialagudaestudiodeseguimiento AT bertrandnpablo analisisacusticodelassibilanciasenlactantesconobstruccionbronquialagudaestudiodeseguimiento AT alvarezgcecilia analisisacusticodelassibilanciasenlactantesconobstruccionbronquialagudaestudiodeseguimiento AT lisboabcarmen analisisacusticodelassibilanciasenlactantesconobstruccionbronquialagudaestudiodeseguimiento
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Análisis acústico de las sibilancias en lactantes con obstrucción bronquial aguda: Estudio de seguimiento

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