Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia

Background: In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells. Aim: To study the in vitro effect...

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Autores principales:	Marcelain C,Katherine, Navarrete S,Carmen Luz, Bravo L,Mireya, Santos A,Manuel, Be R,Cecilia, Pincheira V,Juana
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Ataxia telangiectasia Chromosome fragility Vitamin E
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900001
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spelling	oai:scielo:S0034-988720020009000012005-11-29Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasiaMarcelain C,KatherineNavarrete S,Carmen LuzBravo L,MireyaSantos A,ManuelBe R,CeciliaPincheira V,Juana Ataxia telangiectasia Chromosome fragility Vitamin E Background: In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells. Aim: To study the in vitro effect of vitamin E (DL-alpha-tocopherol) on the frequency of chromosomal damage of lymphocytes from patients with A-T. Patients and methods: Seven patients with A-T and age-sex matched controls were studied. Chromosomal damage in mitosis was evaluated in lymphocytes cultures both under basal conditions and when G2 repair was prevented by 5 mM caffeine. Results: In cells from patients with A-T, vitamin E induced a 57.1 and 47.9% decrease in chromosomal damage under basal and inhibited G2 repair conditions, respectively. However, there was a non significant improvement in their repair activity. Vitamin E effects on chromosomal damage was not significant in control subjects. Conclusions: Vitamin E reduces chromosomal damage in lymphocytes from patients with ataxia telangiectasia (Rev Med Chile 2002; 130: 957-63).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.9 20022002-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900001es10.4067/S0034-98872002000900001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ataxia telangiectasia Chromosome fragility Vitamin E
spellingShingle	Ataxia telangiectasia Chromosome fragility Vitamin E Marcelain C,Katherine Navarrete S,Carmen Luz Bravo L,Mireya Santos A,Manuel Be R,Cecilia Pincheira V,Juana Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
description	Background: In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells. Aim: To study the in vitro effect of vitamin E (DL-alpha-tocopherol) on the frequency of chromosomal damage of lymphocytes from patients with A-T. Patients and methods: Seven patients with A-T and age-sex matched controls were studied. Chromosomal damage in mitosis was evaluated in lymphocytes cultures both under basal conditions and when G2 repair was prevented by 5 mM caffeine. Results: In cells from patients with A-T, vitamin E induced a 57.1 and 47.9% decrease in chromosomal damage under basal and inhibited G2 repair conditions, respectively. However, there was a non significant improvement in their repair activity. Vitamin E effects on chromosomal damage was not significant in control subjects. Conclusions: Vitamin E reduces chromosomal damage in lymphocytes from patients with ataxia telangiectasia (Rev Med Chile 2002; 130: 957-63).
author	Marcelain C,Katherine Navarrete S,Carmen Luz Bravo L,Mireya Santos A,Manuel Be R,Cecilia Pincheira V,Juana
author_facet	Marcelain C,Katherine Navarrete S,Carmen Luz Bravo L,Mireya Santos A,Manuel Be R,Cecilia Pincheira V,Juana
author_sort	Marcelain C,Katherine
title	Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
title_short	Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
title_full	Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
title_fullStr	Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
title_full_unstemmed	Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
title_sort	efecto de la vitamina e(dl alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900001
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Efecto de la vitamina E(DL alfa-tocoferol) sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia

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