Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento

Background: Gastric neuroendocrine tumors correspond to less than 1% of all gastric tumors. These tumors can be of three types. Seventy five percent are type I and are associated to chronic atrophic gastritis type A (CAG- A). Half of them are associated with pernicious anemia. Type II tumors are ass...

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Autores principales:	Lazarte C,Raúl, Poniachik T,Jaime, Smok S,Gladys, Contreras B,Jorge, Gutiérrez C,Luis, Csendes J,Attila
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Gastrinoma Gastritis atrophic Neoplasms hormone-dependent
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900004
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spelling	oai:scielo:S0034-988720020009000042005-11-29Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamientoLazarte C,RaúlPoniachik T,JaimeSmok S,GladysContreras B,JorgeGutiérrez C,LuisCsendes J,Attila Gastrinoma Gastritis atrophic Neoplasms hormone-dependent Background: Gastric neuroendocrine tumors correspond to less than 1% of all gastric tumors. These tumors can be of three types. Seventy five percent are type I and are associated to chronic atrophic gastritis type A (CAG- A). Half of them are associated with pernicious anemia. Type II tumors are associated with Zollinger Ellison syndrome and type I multiple endocrine neoplasia. Type III are sporadic tumors. Aim: To report the clinical, endoscopical features and response to the treatment of gastric neuroendocrine tumors. Patients and methods: A retrospective study of eleven patients (seven male, aged 38 to 72 years old) with a pathological diagnosis of gastric neuroendocrine tumor. Their clinical presentation, associated diseases, treatment and follow up were reviewed. Results: Epigastric pain was present in eight patients, weight loss in three, epigastric pain and weight loss in one and post prandial abdominal pain in two. At endoscopy, multiple polyps in the fundus were observed in six, verrucose gastritis in one, polyps in the antrum in one, two subcardial polyps in 1, a fundus ulcer in one and a Bormann III type lesion in one. Chronic atrophic gastritis was diagnosed in seven patients and pernicious anemia in five. Serum gastrin levels were determined in 4 patients and were high in all. Four subjects were treated with endoscopic polipectomy only. A partial or total gastrectomy was done in seven patients. No complications or mortality occurred during the follow up. Conclusions: Abdominal pain is a common presentation of patients with gastric neuroendocrine neoplasia. Polyps predominantly in the fundus are the most common endoscopic finding. Surgical treatment or endoscopical polypectomy, depending of the extension of the disease, yield satisfactory results (Rev Méd Chile 2002; 130: 985-92).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.9 20022002-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900004es10.4067/S0034-98872002000900004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gastrinoma Gastritis atrophic Neoplasms hormone-dependent
spellingShingle	Gastrinoma Gastritis atrophic Neoplasms hormone-dependent Lazarte C,Raúl Poniachik T,Jaime Smok S,Gladys Contreras B,Jorge Gutiérrez C,Luis Csendes J,Attila Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
description	Background: Gastric neuroendocrine tumors correspond to less than 1% of all gastric tumors. These tumors can be of three types. Seventy five percent are type I and are associated to chronic atrophic gastritis type A (CAG- A). Half of them are associated with pernicious anemia. Type II tumors are associated with Zollinger Ellison syndrome and type I multiple endocrine neoplasia. Type III are sporadic tumors. Aim: To report the clinical, endoscopical features and response to the treatment of gastric neuroendocrine tumors. Patients and methods: A retrospective study of eleven patients (seven male, aged 38 to 72 years old) with a pathological diagnosis of gastric neuroendocrine tumor. Their clinical presentation, associated diseases, treatment and follow up were reviewed. Results: Epigastric pain was present in eight patients, weight loss in three, epigastric pain and weight loss in one and post prandial abdominal pain in two. At endoscopy, multiple polyps in the fundus were observed in six, verrucose gastritis in one, polyps in the antrum in one, two subcardial polyps in 1, a fundus ulcer in one and a Bormann III type lesion in one. Chronic atrophic gastritis was diagnosed in seven patients and pernicious anemia in five. Serum gastrin levels were determined in 4 patients and were high in all. Four subjects were treated with endoscopic polipectomy only. A partial or total gastrectomy was done in seven patients. No complications or mortality occurred during the follow up. Conclusions: Abdominal pain is a common presentation of patients with gastric neuroendocrine neoplasia. Polyps predominantly in the fundus are the most common endoscopic finding. Surgical treatment or endoscopical polypectomy, depending of the extension of the disease, yield satisfactory results (Rev Méd Chile 2002; 130: 985-92).
author	Lazarte C,Raúl Poniachik T,Jaime Smok S,Gladys Contreras B,Jorge Gutiérrez C,Luis Csendes J,Attila
author_facet	Lazarte C,Raúl Poniachik T,Jaime Smok S,Gladys Contreras B,Jorge Gutiérrez C,Luis Csendes J,Attila
author_sort	Lazarte C,Raúl
title	Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
title_short	Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
title_full	Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
title_fullStr	Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
title_full_unstemmed	Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
title_sort	tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900004
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Tumores neuroendocrinos gástricos: presentación clínica, endoscópica y alternativas de tratamiento

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