Neuropatía por disulfiram: Comunicación de tres casos clínicos

Disulfiram is widely used for aversive treatment of alcoholism. Although it is well tolerated in most patients, one in 15,000 patients will develop peripheral neuropathy every year, which is frequently misdiagnosed as alcoholic neuropathy. Disulfiram neuropathy can be mild or severe, depending on di...

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Autores principales:	Bevilacqua,Jorge A, Díaz S,Mario, Díaz T,Violeta, Silva R,Carlos, Fruns Q.,Manuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Alcohol related disorders Disulfiram Drug toxicity Neuropathies
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900012
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spelling	oai:scielo:S0034-988720020009000122005-11-29Neuropatía por disulfiram: Comunicación de tres casos clínicosBevilacqua,Jorge ADíaz S,MarioDíaz T,VioletaSilva R,CarlosFruns Q.,Manuel Alcohol related disorders Disulfiram Drug toxicity Neuropathies Disulfiram is widely used for aversive treatment of alcoholism. Although it is well tolerated in most patients, one in 15,000 patients will develop peripheral neuropathy every year, which is frequently misdiagnosed as alcoholic neuropathy. Disulfiram neuropathy can be mild or severe, depending on diverse factors such as time of exposure and the dosage. Most patients will present with a motor-sensory neuropathy of the lower limbs, which tends to improve as disulfiram administration ceases, however some cases may remain with permanent sequelae. We report the clinical, laboratory and electrophysiological features of three patients who developed disulfiram neuropathy during treatment of alcoholism. Recovery was incomplete at 8 weeks after treatment cessation in all of them. No other findings justified the clinical features described in these patients. Considering the incidence of alcoholism and the wide use of disulfiram treatment in Chile, we suggest that disulfiram neuropathy is being underdiagnosed. We also stress the fact that disulfiram neuropathy could be avoided by using lower doses (Rev Méd Chile 2002; 130: 1037-42).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.9 20022002-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900012es10.4067/S0034-98872002000900012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alcohol related disorders Disulfiram Drug toxicity Neuropathies
spellingShingle	Alcohol related disorders Disulfiram Drug toxicity Neuropathies Bevilacqua,Jorge A Díaz S,Mario Díaz T,Violeta Silva R,Carlos Fruns Q.,Manuel Neuropatía por disulfiram: Comunicación de tres casos clínicos
description	Disulfiram is widely used for aversive treatment of alcoholism. Although it is well tolerated in most patients, one in 15,000 patients will develop peripheral neuropathy every year, which is frequently misdiagnosed as alcoholic neuropathy. Disulfiram neuropathy can be mild or severe, depending on diverse factors such as time of exposure and the dosage. Most patients will present with a motor-sensory neuropathy of the lower limbs, which tends to improve as disulfiram administration ceases, however some cases may remain with permanent sequelae. We report the clinical, laboratory and electrophysiological features of three patients who developed disulfiram neuropathy during treatment of alcoholism. Recovery was incomplete at 8 weeks after treatment cessation in all of them. No other findings justified the clinical features described in these patients. Considering the incidence of alcoholism and the wide use of disulfiram treatment in Chile, we suggest that disulfiram neuropathy is being underdiagnosed. We also stress the fact that disulfiram neuropathy could be avoided by using lower doses (Rev Méd Chile 2002; 130: 1037-42).
author	Bevilacqua,Jorge A Díaz S,Mario Díaz T,Violeta Silva R,Carlos Fruns Q.,Manuel
author_facet	Bevilacqua,Jorge A Díaz S,Mario Díaz T,Violeta Silva R,Carlos Fruns Q.,Manuel
author_sort	Bevilacqua,Jorge A
title	Neuropatía por disulfiram: Comunicación de tres casos clínicos
title_short	Neuropatía por disulfiram: Comunicación de tres casos clínicos
title_full	Neuropatía por disulfiram: Comunicación de tres casos clínicos
title_fullStr	Neuropatía por disulfiram: Comunicación de tres casos clínicos
title_full_unstemmed	Neuropatía por disulfiram: Comunicación de tres casos clínicos
title_sort	neuropatía por disulfiram: comunicación de tres casos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900012
work_keys_str_mv	AT bevilacquajorgea neuropatiapordisulfiramcomunicaciondetrescasosclinicos AT diazsmario neuropatiapordisulfiramcomunicaciondetrescasosclinicos AT diaztvioleta neuropatiapordisulfiramcomunicaciondetrescasosclinicos AT silvarcarlos neuropatiapordisulfiramcomunicaciondetrescasosclinicos AT frunsqmanuel neuropatiapordisulfiramcomunicaciondetrescasosclinicos
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Neuropatía por disulfiram: Comunicación de tres casos clínicos

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