El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología

Cytokine unbalance is responsible for the pathogenesis of diverse inflammatory, autoimmune and infectious diseases, and Tumor Necrosis Factor Alpha (TNFalpha), among other cytokines, plays a central role. TNFalpha production can be regulated at the transcriptional, post-transcriptional, and translat...

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Autores principales:	Aguillón G,Juan C, Cruzat C,Andrea, Cuenca M,Jimena, Cuchacovich T,Miguel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Cytokines Polymorphism (Genetics) Tumor necrosis factor
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900013
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spelling	oai:scielo:S0034-988720020009000132005-11-29El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patologíaAguillón G,Juan CCruzat C,AndreaCuenca M,JimenaCuchacovich T,Miguel Cytokines Polymorphism (Genetics) Tumor necrosis factor Cytokine unbalance is responsible for the pathogenesis of diverse inflammatory, autoimmune and infectious diseases, and Tumor Necrosis Factor Alpha (TNFalpha), among other cytokines, plays a central role. TNFalpha production can be regulated at the transcriptional, post-transcriptional, and translational levels. Variability in the promoter and coding regions of the TNFalpha gene may modulate the magnitude of its secretory response. Up to date, several single nucleotide polymorphisms (SNPs) have been identified in the human TNFalpha gene promoter. One of these, is a guanine to adenine transition at position -308, that generates the TNF1 and TNF2 alleles, respectively. The TNF2 allele is associated to a high in vitro TNF expression, and it has also been linked to an increased susceptibility and severity, for a variety of illnesses, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer disease and cerebral malaria among others. It is also associated with a higher septic shock susceptibility and mortality. The investigation of polymorphisms within the TNFalpha cluster will be important in understanding the role of TNFalpha regulation in specific diseases (Rev Méd Chile 2002; 130: 1043-50).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.9 20022002-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900013es10.4067/S0034-98872002000900013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cytokines Polymorphism (Genetics) Tumor necrosis factor
spellingShingle	Cytokines Polymorphism (Genetics) Tumor necrosis factor Aguillón G,Juan C Cruzat C,Andrea Cuenca M,Jimena Cuchacovich T,Miguel El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
description	Cytokine unbalance is responsible for the pathogenesis of diverse inflammatory, autoimmune and infectious diseases, and Tumor Necrosis Factor Alpha (TNFalpha), among other cytokines, plays a central role. TNFalpha production can be regulated at the transcriptional, post-transcriptional, and translational levels. Variability in the promoter and coding regions of the TNFalpha gene may modulate the magnitude of its secretory response. Up to date, several single nucleotide polymorphisms (SNPs) have been identified in the human TNFalpha gene promoter. One of these, is a guanine to adenine transition at position -308, that generates the TNF1 and TNF2 alleles, respectively. The TNF2 allele is associated to a high in vitro TNF expression, and it has also been linked to an increased susceptibility and severity, for a variety of illnesses, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer disease and cerebral malaria among others. It is also associated with a higher septic shock susceptibility and mortality. The investigation of polymorphisms within the TNFalpha cluster will be important in understanding the role of TNFalpha regulation in specific diseases (Rev Méd Chile 2002; 130: 1043-50).
author	Aguillón G,Juan C Cruzat C,Andrea Cuenca M,Jimena Cuchacovich T,Miguel
author_facet	Aguillón G,Juan C Cruzat C,Andrea Cuenca M,Jimena Cuchacovich T,Miguel
author_sort	Aguillón G,Juan C
title	El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
title_short	El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
title_full	El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
title_fullStr	El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
title_full_unstemmed	El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
title_sort	el polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002000900013
work_keys_str_mv	AT aguillongjuanc elpolimorfismogeneticodelfactordenecrosistumoralalfacomofactorderiesgoenpatologia AT cruzatcandrea elpolimorfismogeneticodelfactordenecrosistumoralalfacomofactorderiesgoenpatologia AT cuencamjimena elpolimorfismogeneticodelfactordenecrosistumoralalfacomofactorderiesgoenpatologia AT cuchacovichtmiguel elpolimorfismogeneticodelfactordenecrosistumoralalfacomofactorderiesgoenpatologia
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El polimorfismo genético del factor de necrosis tumoral alfa como factor de riesgo en patología

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