Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos

Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11ß-hydroxysteroid dehydrogenase type 2 (11ßHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the inte...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mosso G,Lorena, Carvajal M,Cristian, CampinoJ,Carmen, Rojas O,Auristela, González P,Alexis, Barraza M,Adolfo, Montero L,Joaquín, Fardella B,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Aldosterone Hypertension Renin-angiotensin system 11ß-Hydroxysteroid dehydrogenases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100001
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872002001100001
record_format	dspace
spelling	oai:scielo:S0034-988720020011000012005-11-23Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenosMosso G,LorenaCarvajal M,CristianCampinoJ,CarmenRojas O,AuristelaGonzález P,AlexisBarraza M,AdolfoMontero L,JoaquínFardella B,Carlos Aldosterone Hypertension Renin-angiotensin system 11ß-Hydroxysteroid dehydrogenases Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11ß-hydroxysteroid dehydrogenase type 2 (11ßHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11ßHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 µg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 µg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11ßHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.11 20022002-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100001es10.4067/S0034-98872002001100001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aldosterone Hypertension Renin-angiotensin system 11ß-Hydroxysteroid dehydrogenases
spellingShingle	Aldosterone Hypertension Renin-angiotensin system 11ß-Hydroxysteroid dehydrogenases Mosso G,Lorena Carvajal M,Cristian CampinoJ,Carmen Rojas O,Auristela González P,Alexis Barraza M,Adolfo Montero L,Joaquín Fardella B,Carlos Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
description	Background: Half of hypertensive patients with low plasma renin activity have a primary hyperaldosteronism. Among the remaining half, 11ß-hydroxysteroid dehydrogenase type 2 (11ßHSD2) deficiency plays an important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11ßHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ng/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1±3.3 and 9.2±2.8 µg/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4±1.3 and 3.7±1.2 µg/dl, respectively). Four hypertensive subjects had an abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with low plasma renin activity and aldosterone had biochemical alterations suggestive of 11ßHSD2 deficiency (Rev Méd Chile 2002; 130: 1201-8).
author	Mosso G,Lorena Carvajal M,Cristian CampinoJ,Carmen Rojas O,Auristela González P,Alexis Barraza M,Adolfo Montero L,Joaquín Fardella B,Carlos
author_facet	Mosso G,Lorena Carvajal M,Cristian CampinoJ,Carmen Rojas O,Auristela González P,Alexis Barraza M,Adolfo Montero L,Joaquín Fardella B,Carlos
author_sort	Mosso G,Lorena
title	Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
title_short	Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
title_full	Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
title_fullStr	Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
title_full_unstemmed	Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
title_sort	actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100001
work_keys_str_mv	AT mossoglorena actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT carvajalmcristian actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT campinojcarmen actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT rojasoauristela actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT gonzalezpalexis actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT barrazamadolfo actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT monteroljoaquin actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos AT fardellabcarlos actividadde11betahidroxiesteroidedehidrogenasatipo2enhipertensoschilenos
_version_	1718436064121585664

Actividad de 11 beta hidroxiesteroide dehidrogenasa tipo 2 en hipertensos chilenos

Ejemplares similares