Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile

Background: Insulin resistance is defined as an inappropriate high level of plasma insulin required to maintain metabolic homeostasis. It is associated with type 2 diabetes and cardiovascular diseases. The glucose clamp technique is the standard method for the measurement of insulin resistance. Howe...

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Autores principales:	Acosta B,Ana M, Escalona O,Manuel, Maiz G,Alberto, Pollak C,Felipe, Leighton P,Federico
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Diabetes mellitus Glucose clamp technique Glucose tolerance test Insulin resistance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100004
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spelling	oai:scielo:S0034-988720020011000042005-11-23Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de ChileAcosta B,Ana MEscalona O,ManuelMaiz G,AlbertoPollak C,FelipeLeighton P,Federico Diabetes mellitus Glucose clamp technique Glucose tolerance test Insulin resistance Background: Insulin resistance is defined as an inappropriate high level of plasma insulin required to maintain metabolic homeostasis. It is associated with type 2 diabetes and cardiovascular diseases. The glucose clamp technique is the standard method for the measurement of insulin resistance. However, this method is laborious, expensive and impractical to perform in epidemiological investigations. The homeostasis model assessment (HOMA) has been proposed to assess insulin resistance and secretion, using fasting glucose and insulin concentrations. Aim: To measure insulin resistance using HOMA (HOMAir) in a population sample from the Metropolitan Region in Chile. Material and Methods: One hundred twenty subjects (59 female) with a normal body mass index and fasting blood glucose were studied. Fasting plasma glucose was measured by a glucose oxidase method and serum insulin was measured by radio immunoassay. Results: Fasting blood glucose was 81.6±9.4 mg/dl and serum insulin was 9.7±2.4 µU/ml. Mean HOMA insulin resistance was 1.96±0.57 (range 0.5 and 3.0). Conclusions: These HOMA values can be used as reference for Chilean non obese individuals (Rev Méd Chile 2002; 130: 1227-31)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.11 20022002-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100004es10.4067/S0034-98872002001100004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus Glucose clamp technique Glucose tolerance test Insulin resistance
spellingShingle	Diabetes mellitus Glucose clamp technique Glucose tolerance test Insulin resistance Acosta B,Ana M Escalona O,Manuel Maiz G,Alberto Pollak C,Felipe Leighton P,Federico Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
description	Background: Insulin resistance is defined as an inappropriate high level of plasma insulin required to maintain metabolic homeostasis. It is associated with type 2 diabetes and cardiovascular diseases. The glucose clamp technique is the standard method for the measurement of insulin resistance. However, this method is laborious, expensive and impractical to perform in epidemiological investigations. The homeostasis model assessment (HOMA) has been proposed to assess insulin resistance and secretion, using fasting glucose and insulin concentrations. Aim: To measure insulin resistance using HOMA (HOMAir) in a population sample from the Metropolitan Region in Chile. Material and Methods: One hundred twenty subjects (59 female) with a normal body mass index and fasting blood glucose were studied. Fasting plasma glucose was measured by a glucose oxidase method and serum insulin was measured by radio immunoassay. Results: Fasting blood glucose was 81.6±9.4 mg/dl and serum insulin was 9.7±2.4 µU/ml. Mean HOMA insulin resistance was 1.96±0.57 (range 0.5 and 3.0). Conclusions: These HOMA values can be used as reference for Chilean non obese individuals (Rev Méd Chile 2002; 130: 1227-31)
author	Acosta B,Ana M Escalona O,Manuel Maiz G,Alberto Pollak C,Felipe Leighton P,Federico
author_facet	Acosta B,Ana M Escalona O,Manuel Maiz G,Alberto Pollak C,Felipe Leighton P,Federico
author_sort	Acosta B,Ana M
title	Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
title_short	Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
title_full	Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
title_fullStr	Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
title_full_unstemmed	Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile
title_sort	determinación del índice de resistencia insulínica mediante homa en una población de la región metropolitana de chile
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100004
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Determinación del índice de resistencia insulínica mediante HOMA en una población de la Región Metropolitana de Chile

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