Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas

In case-control studies, spurious associations between allelic variants in candidate genes and disease may arise as a result of population stratification by ethnicity. In epidemiological terms, the ethnic group would act as a confounding factor if both the genotype frequency and the incidence/preval...

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Autores principales:	Santos,José Luis, Pérez,Francisco, Carrasco,Elena, Albala,Cecilia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Genetics, medical Genetics, population Genotype Polymorphinsm (Genetics)
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100016
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spelling	oai:scielo:S0034-988720020011000162005-11-23Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejasSantos,José LuisPérez,FranciscoCarrasco,ElenaAlbala,Cecilia Genetics, medical Genetics, population Genotype Polymorphinsm (Genetics) In case-control studies, spurious associations between allelic variants in candidate genes and disease may arise as a result of population stratification by ethnicity. In epidemiological terms, the ethnic group would act as a confounding factor if both the genotype frequency and the incidence/prevalence of a given chronic disease vary across ethnic groups. Population stratification is a key element in the study of population dynamics and the knowledge of the disparity in health-related conditions among strata has important social and public health implications. However, it would not be scientifically correct to conclude a causal gene-disease association in situations in which the association arises as a consequence of a particular population structure. Although the relevance and magnitude of the bias derived from this confounding, effect would be different depending on the population considered, there has been an increased use of study designs such as the case-parent study, that avoids the effect of population stratification by ethnicity. In this article, we review the analysis of case-parent trios using unrelated affected cases as an epidemiological study design for testing association between genetic polymorphisms and disease (Rev Méd Chile 2002; 130: 1307-15).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.11 20022002-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100016es10.4067/S0034-98872002001100016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Genetics, medical Genetics, population Genotype Polymorphinsm (Genetics)
spellingShingle	Genetics, medical Genetics, population Genotype Polymorphinsm (Genetics) Santos,José Luis Pérez,Francisco Carrasco,Elena Albala,Cecilia Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
description	In case-control studies, spurious associations between allelic variants in candidate genes and disease may arise as a result of population stratification by ethnicity. In epidemiological terms, the ethnic group would act as a confounding factor if both the genotype frequency and the incidence/prevalence of a given chronic disease vary across ethnic groups. Population stratification is a key element in the study of population dynamics and the knowledge of the disparity in health-related conditions among strata has important social and public health implications. However, it would not be scientifically correct to conclude a causal gene-disease association in situations in which the association arises as a consequence of a particular population structure. Although the relevance and magnitude of the bias derived from this confounding, effect would be different depending on the population considered, there has been an increased use of study designs such as the case-parent study, that avoids the effect of population stratification by ethnicity. In this article, we review the analysis of case-parent trios using unrelated affected cases as an epidemiological study design for testing association between genetic polymorphisms and disease (Rev Méd Chile 2002; 130: 1307-15).
author	Santos,José Luis Pérez,Francisco Carrasco,Elena Albala,Cecilia
author_facet	Santos,José Luis Pérez,Francisco Carrasco,Elena Albala,Cecilia
author_sort	Santos,José Luis
title	Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
title_short	Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
title_full	Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
title_fullStr	Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
title_full_unstemmed	Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
title_sort	uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001100016
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Uso de tríos caso-padres en estudios epidemiológicos de asociación entre polimorfismos genéticos y enfermedades complejas

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