Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina

Background: Subserous gallbladder carcinoma is difficult to diagnose and treat. There are no tissue markers with prognostic value in this type of tumor. Aim: To study the immunohistochemical expression of E-cadherin alpha and beta catenin in subserous gallbladder carcinoma. Patients and methods: One...

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Autores principales:	Roa E,Iván, Ibacache S,Gilda, Melo A,Angélica, Morales M,Erick, Villaseca H,Miguel, Araya O,Juan, Roa S,Juan, Guzmán G,Pablo, de Aretxabala U,Xabier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2002
Materias:	Cadherins Gallbladder Neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001200004
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spelling	oai:scielo:S0034-988720020012000042003-02-05Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-cateninaRoa E,IvánIbacache S,GildaMelo A,AngélicaMorales M,ErickVillaseca H,MiguelAraya O,JuanRoa S,JuanGuzmán G,Pablode Aretxabala U,Xabier Cadherins Gallbladder Neoplasms Background: Subserous gallbladder carcinoma is difficult to diagnose and treat. There are no tissue markers with prognostic value in this type of tumor. Aim: To study the immunohistochemical expression of E-cadherin alpha and beta catenin in subserous gallbladder carcinoma. Patients and methods: One hundred seventeen subjects (103 women and 14 men aged 62 and 69 years as a mean, respectively), were studied. Thirty five gallbladder samples without evidence of cancer were used as controls. Expression of markers was studied with standard immunohistochemical techniques for formalin fixed and paraffin embedded tissue. Results: Ninety seven percent of tumors were adenocarcinoma. A lower or absent expression of E-cadherin, alpha catenin and beta catenin was observed in 26, 33 and 29% of tumors, respectively. Actuarial five years survival was 37%. No association between macroscopic features of the tumor and survival was observed. Well differentiated tumors had a 73% survival, whereas less differentiated tumors had a 30% survival. Tumors with a normal expression of the markers had a slightly better survival, although not significant (p=0.06). Conclusions: Approximately 30% of subserous gallbladder carcinoma have an abnormal expression of E-cadherin, alpha catenin and beta catenin. This abnormal expression has no relationship with prognosis and is probably secondary to the aberrant genic expression of the tumor (Rev Méd Chile 2002; 130: 1349-57)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.130 n.12 20022002-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001200004es10.4067/S0034-98872002001200004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cadherins Gallbladder Neoplasms
spellingShingle	Cadherins Gallbladder Neoplasms Roa E,Iván Ibacache S,Gilda Melo A,Angélica Morales M,Erick Villaseca H,Miguel Araya O,Juan Roa S,Juan Guzmán G,Pablo de Aretxabala U,Xabier Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
description	Background: Subserous gallbladder carcinoma is difficult to diagnose and treat. There are no tissue markers with prognostic value in this type of tumor. Aim: To study the immunohistochemical expression of E-cadherin alpha and beta catenin in subserous gallbladder carcinoma. Patients and methods: One hundred seventeen subjects (103 women and 14 men aged 62 and 69 years as a mean, respectively), were studied. Thirty five gallbladder samples without evidence of cancer were used as controls. Expression of markers was studied with standard immunohistochemical techniques for formalin fixed and paraffin embedded tissue. Results: Ninety seven percent of tumors were adenocarcinoma. A lower or absent expression of E-cadherin, alpha catenin and beta catenin was observed in 26, 33 and 29% of tumors, respectively. Actuarial five years survival was 37%. No association between macroscopic features of the tumor and survival was observed. Well differentiated tumors had a 73% survival, whereas less differentiated tumors had a 30% survival. Tumors with a normal expression of the markers had a slightly better survival, although not significant (p=0.06). Conclusions: Approximately 30% of subserous gallbladder carcinoma have an abnormal expression of E-cadherin, alpha catenin and beta catenin. This abnormal expression has no relationship with prognosis and is probably secondary to the aberrant genic expression of the tumor (Rev Méd Chile 2002; 130: 1349-57)
author	Roa E,Iván Ibacache S,Gilda Melo A,Angélica Morales M,Erick Villaseca H,Miguel Araya O,Juan Roa S,Juan Guzmán G,Pablo de Aretxabala U,Xabier
author_facet	Roa E,Iván Ibacache S,Gilda Melo A,Angélica Morales M,Erick Villaseca H,Miguel Araya O,Juan Roa S,Juan Guzmán G,Pablo de Aretxabala U,Xabier
author_sort	Roa E,Iván
title	Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
title_short	Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
title_full	Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
title_fullStr	Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
title_full_unstemmed	Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
title_sort	carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
publisher	Sociedad Médica de Santiago
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872002001200004
work_keys_str_mv	AT roaeivan carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT ibacachesgilda carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT meloaangelica carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT moralesmerick carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT villasecahmiguel carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT arayaojuan carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT roasjuan carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT guzmangpablo carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina AT dearetxabalauxabier carcinomasubserosodelavesiculabiliarexpresiondelcomplejocaderinacatenina
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Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina

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