Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico
Background: Polymorphisms of Fc receptors for IgG (FcgR) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human FcgRIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracelular...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Lenguaje: | Spanish / Castilian |
| Publicado: |
Sociedad Médica de Santiago
2003
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100002 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0034-98872003000100002 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0034-988720030001000022003-05-13Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémicoCarrión A,FlavioFigueroa E,FernandoMartínez R,M EugeniaMassardo V,LoretoPérez G,TamaraFoster B,CarolinaMancilla M,CeciliaNeira Q,OscarGuzmán B,LeonardoValenzuela M,VivianaUrrutia L,RamónCarmona G,SergioFigueroa,MaximilianoLubiano A,AlessandraWainstein G,Eduardo Lupus erythematosus, systemic Lupus nephritis Receptors IgG Background: Polymorphisms of Fc receptors for IgG (FcgR) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human FcgRIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracelular domain (histidine or arginine respectively) and differ substantially in their ability to bind human IgG2. The H131 allele binds IgG2 efficiently, whereas R131 binds it poorly. Because IgG2 is a poor activator of the classical complement pathway, the H131 is essential for the disposal of IgG2 immune complexes. Aim: To determine the distribution of FcgRIIA genes in a cohort of Chilean SLE patients, with or without a history of lupus nephritis. Patients and methods: We studied 52 Chilean SLE patients fulfilling the 1982 American College of Rheumatology (ACR) criteria, 20 of whom had a history of nephritis, and 44 ethnically matched disease-free controls. FcgRIIa allotypes were genotyped by PCR. Results: No significant association was observed between the low affinity FcgRII receptor (FcgRIIa-R131) and the presence of SLE or lupus nephritis. However, genotype frequencies in SLE patients but not in controls, departed from the proportions predicted by the Hardy-Weinberg equilibrium, suggesting this locus might be related to the disease. Conclusions: Our results suggest that in Chilean patients with SLE, as well as in many other populations, the R131 allotype is not a major factor predisposing to the development of SLE or lupus nephritis (Rev Méd Chile 2003; 131: 11-18)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.1 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100002es10.4067/S0034-98872003000100002 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Lupus erythematosus, systemic Lupus nephritis Receptors IgG |
| spellingShingle |
Lupus erythematosus, systemic Lupus nephritis Receptors IgG Carrión A,Flavio Figueroa E,Fernando Martínez R,M Eugenia Massardo V,Loreto Pérez G,Tamara Foster B,Carolina Mancilla M,Cecilia Neira Q,Oscar Guzmán B,Leonardo Valenzuela M,Viviana Urrutia L,Ramón Carmona G,Sergio Figueroa,Maximiliano Lubiano A,Alessandra Wainstein G,Eduardo Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| description |
Background: Polymorphisms of Fc receptors for IgG (FcgR) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human FcgRIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracelular domain (histidine or arginine respectively) and differ substantially in their ability to bind human IgG2. The H131 allele binds IgG2 efficiently, whereas R131 binds it poorly. Because IgG2 is a poor activator of the classical complement pathway, the H131 is essential for the disposal of IgG2 immune complexes. Aim: To determine the distribution of FcgRIIA genes in a cohort of Chilean SLE patients, with or without a history of lupus nephritis. Patients and methods: We studied 52 Chilean SLE patients fulfilling the 1982 American College of Rheumatology (ACR) criteria, 20 of whom had a history of nephritis, and 44 ethnically matched disease-free controls. FcgRIIa allotypes were genotyped by PCR. Results: No significant association was observed between the low affinity FcgRII receptor (FcgRIIa-R131) and the presence of SLE or lupus nephritis. However, genotype frequencies in SLE patients but not in controls, departed from the proportions predicted by the Hardy-Weinberg equilibrium, suggesting this locus might be related to the disease. Conclusions: Our results suggest that in Chilean patients with SLE, as well as in many other populations, the R131 allotype is not a major factor predisposing to the development of SLE or lupus nephritis (Rev Méd Chile 2003; 131: 11-18) |
| author |
Carrión A,Flavio Figueroa E,Fernando Martínez R,M Eugenia Massardo V,Loreto Pérez G,Tamara Foster B,Carolina Mancilla M,Cecilia Neira Q,Oscar Guzmán B,Leonardo Valenzuela M,Viviana Urrutia L,Ramón Carmona G,Sergio Figueroa,Maximiliano Lubiano A,Alessandra Wainstein G,Eduardo |
| author_facet |
Carrión A,Flavio Figueroa E,Fernando Martínez R,M Eugenia Massardo V,Loreto Pérez G,Tamara Foster B,Carolina Mancilla M,Cecilia Neira Q,Oscar Guzmán B,Leonardo Valenzuela M,Viviana Urrutia L,Ramón Carmona G,Sergio Figueroa,Maximiliano Lubiano A,Alessandra Wainstein G,Eduardo |
| author_sort |
Carrión A,Flavio |
| title |
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| title_short |
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| title_full |
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| title_fullStr |
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| title_full_unstemmed |
Estudio del polimorfismo de receptores FcgammaIIa en pacientes chilenos con lupus eritematoso sistémico |
| title_sort |
estudio del polimorfismo de receptores fcgammaiia en pacientes chilenos con lupus eritematoso sistémico |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2003 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100002 |
| work_keys_str_mv |
AT carrionaflavio estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT figueroaefernando estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT martinezrmeugenia estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT massardovloreto estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT perezgtamara estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT fosterbcarolina estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT mancillamcecilia estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT neiraqoscar estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT guzmanbleonardo estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT valenzuelamviviana estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT urrutialramon estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT carmonagsergio estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT figueroamaximiliano estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT lubianoaalessandra estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico AT wainsteingeduardo estudiodelpolimorfismodereceptoresfcgammaiiaenpacienteschilenosconlupuseritematososistemico |
| _version_ |
1718436073472786432 |