Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca

Background: The diagnosis of celiac disease is based in clinical features, serology and intestinal biopsy. There are recent reports that antiglutaminase antibodies have a good correlation with anti endomisial antibodies. Aim: To assess the sensitivity and specificity of antitransglutaminase antibodi...

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Autores principales:	Weitz V,Juan Carlos, Montalva D,Rebeca, Alarcón O,Teresa, Contreras M,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Antibody specificity Celiac disease Gluten Transglutaminase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100005
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spelling	oai:scielo:S0034-988720030001000052003-05-13Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíacaWeitz V,Juan CarlosMontalva D,RebecaAlarcón O,TeresaContreras M,Luis Antibody specificity Celiac disease Gluten Transglutaminase Background: The diagnosis of celiac disease is based in clinical features, serology and intestinal biopsy. There are recent reports that antiglutaminase antibodies have a good correlation with anti endomisial antibodies. Aim: To assess the sensitivity and specificity of antitransglutaminase antibodies in the diagnosis of celiac disease and their correlation with antiendomisial antibodies. Material and methods: Forty nine patients with celiac disease (mean age 30 years, 12 male) were studied. Thirty were symptomatic and 19, asymptomatic. As controls, 34 subjects (mean age 27 years, seven male), with normal duodenal biopsies, were studied. Sera was processed for the determination of antigliadin IgA by ELISA, antiendomisium IgA by indirect immunofluorescence, and antitransglutaminase IgA by ELISA. Results: Antigliadin antibodies had a sensitivity of 73%, a specificity of 96%, a positive predictive value of 93% and a negative predictive value of 82% for the diagnosis of celiac disease. Antiendomisium and antitransglutaminase antibodies had a specificity and positive predictive value of 100%, sensitivities of 89 and 92% respectively and negative predictive values of 92 and 94% respectively. No significant differences in the diagnostic yield of antiendomisium and antitransglutaminase antibodies, were observed. Conclusions: In this group of patients, antitransglutaminase antibodies had a high concordance with antiendomisium antibodies, for the diagnosis of celiac disease. Considering that the determination of antitransglutaminase antibodies is of lower cost and less complicated than antiendomisium antibodies, it is a useful tool for the diagnosis and follow up of patients with celiac disease (Rev Méd Chile 2003; 131: 31-6)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.1 20032003-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100005es10.4067/S0034-98872003000100005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibody specificity Celiac disease Gluten Transglutaminase
spellingShingle	Antibody specificity Celiac disease Gluten Transglutaminase Weitz V,Juan Carlos Montalva D,Rebeca Alarcón O,Teresa Contreras M,Luis Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
description	Background: The diagnosis of celiac disease is based in clinical features, serology and intestinal biopsy. There are recent reports that antiglutaminase antibodies have a good correlation with anti endomisial antibodies. Aim: To assess the sensitivity and specificity of antitransglutaminase antibodies in the diagnosis of celiac disease and their correlation with antiendomisial antibodies. Material and methods: Forty nine patients with celiac disease (mean age 30 years, 12 male) were studied. Thirty were symptomatic and 19, asymptomatic. As controls, 34 subjects (mean age 27 years, seven male), with normal duodenal biopsies, were studied. Sera was processed for the determination of antigliadin IgA by ELISA, antiendomisium IgA by indirect immunofluorescence, and antitransglutaminase IgA by ELISA. Results: Antigliadin antibodies had a sensitivity of 73%, a specificity of 96%, a positive predictive value of 93% and a negative predictive value of 82% for the diagnosis of celiac disease. Antiendomisium and antitransglutaminase antibodies had a specificity and positive predictive value of 100%, sensitivities of 89 and 92% respectively and negative predictive values of 92 and 94% respectively. No significant differences in the diagnostic yield of antiendomisium and antitransglutaminase antibodies, were observed. Conclusions: In this group of patients, antitransglutaminase antibodies had a high concordance with antiendomisium antibodies, for the diagnosis of celiac disease. Considering that the determination of antitransglutaminase antibodies is of lower cost and less complicated than antiendomisium antibodies, it is a useful tool for the diagnosis and follow up of patients with celiac disease (Rev Méd Chile 2003; 131: 31-6)
author	Weitz V,Juan Carlos Montalva D,Rebeca Alarcón O,Teresa Contreras M,Luis
author_facet	Weitz V,Juan Carlos Montalva D,Rebeca Alarcón O,Teresa Contreras M,Luis
author_sort	Weitz V,Juan Carlos
title	Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
title_short	Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
title_full	Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
title_fullStr	Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
title_full_unstemmed	Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
title_sort	determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000100005
work_keys_str_mv	AT weitzvjuancarlos determinaciondeanticuerposantitransglutaminasaeneldiagnosticodeenfermedadceliaca AT montalvadrebeca determinaciondeanticuerposantitransglutaminasaeneldiagnosticodeenfermedadceliaca AT alarconoteresa determinaciondeanticuerposantitransglutaminasaeneldiagnosticodeenfermedadceliaca AT contrerasmluis determinaciondeanticuerposantitransglutaminasaeneldiagnosticodeenfermedadceliaca
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Determinación de anticuerpos anti-transglutaminasa en el diagnóstico de enfermedad celíaca

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