Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile

Genes for dopamine receptor DRD4 and dopamine transporter DAT1 are highly polymorphic. Two alleles of these genes, namely the DRD4.7 and the DAT1*9 are frequently associated to the attention deficit disorder with hyperactivity. In Europe, the allele for DRD4 receptor with four repetitions (DRD4.4) h...

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Autores principales:	Vieyra S,Gonzalo, Moraga V,Mauricio, Henríquez B,Hugo, Aboitiz D,Francisco, Rothhammer E,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Alleles Carrier proteins Gene frequency Receptors dopamine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000200002
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id	oai:scielo:S0034-98872003000200002
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spelling	oai:scielo:S0034-988720030002000022005-11-22Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de ChileVieyra S,GonzaloMoraga V,MauricioHenríquez B,HugoAboitiz D,FranciscoRothhammer E,Francisco Alleles Carrier proteins Gene frequency Receptors dopamine Genes for dopamine receptor DRD4 and dopamine transporter DAT1 are highly polymorphic. Two alleles of these genes, namely the DRD4.7 and the DAT19 are frequently associated to the attention deficit disorder with hyperactivity. In Europe, the allele for DRD4 receptor with four repetitions (DRD4.4) has the highest frequency, with a median of 69%, followed by DRD4.7, with a frequency of 15%. South American indigenous populations have higher frequencies for DRD4.7 (61%) than for DRD4.4 (29%). The ten repetition allele for DAT1 transporter has a high frequency among Europeans (72%) and Amerindians (100%). The allele DAT19 is the second most frequent allele. Aim: To study the frequency of DRD4 and DAT1 alleles in a Chilean population sample. Material and methods: One hundred serum samples were obtained from blood donors in two public hospitals in Santiago. Polymorphic regions for DRD4 and DAT1 were amplified by polymerase chain reaction. Results: The allele DRD4.4 had a frequency of 59% and DRD4.7 a frequency of 27%. The allele DAT110 had a frequency of 74%, followed by DAT 19, with a frequency of 23%. Discussion: In a Chilean population sample, the frequency of DRD4 and DAT1 alleles was very similar to that of European populations (Rev Méd Chile 2003; 131: 135-43)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.2 20032003-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000200002es10.4067/S0034-98872003000200002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alleles Carrier proteins Gene frequency Receptors dopamine
spellingShingle	Alleles Carrier proteins Gene frequency Receptors dopamine Vieyra S,Gonzalo Moraga V,Mauricio Henríquez B,Hugo Aboitiz D,Francisco Rothhammer E,Francisco Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
description	Genes for dopamine receptor DRD4 and dopamine transporter DAT1 are highly polymorphic. Two alleles of these genes, namely the DRD4.7 and the DAT19 are frequently associated to the attention deficit disorder with hyperactivity. In Europe, the allele for DRD4 receptor with four repetitions (DRD4.4) has the highest frequency, with a median of 69%, followed by DRD4.7, with a frequency of 15%. South American indigenous populations have higher frequencies for DRD4.7 (61%) than for DRD4.4 (29%). The ten repetition allele for DAT1 transporter has a high frequency among Europeans (72%) and Amerindians (100%). The allele DAT19 is the second most frequent allele. Aim: To study the frequency of DRD4 and DAT1 alleles in a Chilean population sample. Material and methods: One hundred serum samples were obtained from blood donors in two public hospitals in Santiago. Polymorphic regions for DRD4 and DAT1 were amplified by polymerase chain reaction. Results: The allele DRD4.4 had a frequency of 59% and DRD4.7 a frequency of 27%. The allele DAT110 had a frequency of 74%, followed by DAT 19, with a frequency of 23%. Discussion: In a Chilean population sample, the frequency of DRD4 and DAT1 alleles was very similar to that of European populations (Rev Méd Chile 2003; 131: 135-43)
author	Vieyra S,Gonzalo Moraga V,Mauricio Henríquez B,Hugo Aboitiz D,Francisco Rothhammer E,Francisco
author_facet	Vieyra S,Gonzalo Moraga V,Mauricio Henríquez B,Hugo Aboitiz D,Francisco Rothhammer E,Francisco
author_sort	Vieyra S,Gonzalo
title	Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
title_short	Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
title_full	Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
title_fullStr	Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
title_full_unstemmed	Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile
title_sort	distribución de alelos de los genes drd4 y dat1 del sistema dopaminérgico en la población mixta de santiago de chile
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000200002
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Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile

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