Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos

Background: Infantile obesity is a probable risk factor for the early appearance of chronic illnesses like Type 2 Diabetes Mellitus, Dislipidemia and Hypertension. Insulin Resistance (IR) appears as the common etiological mechanism. Aim: To describe metabolic complications associated to obesity in a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Barja Y,Salesa, Arteaga Ll,Antonio, Acosta B,Ana M, Hodgson B.,M Isabel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Child nutrition disorders Hyperinsulinemia Hyperlipidemia Hypertension Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872003000300003
record_format	dspace
spelling	oai:scielo:S0034-988720030003000032004-12-13Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenosBarja Y,SalesaArteaga Ll,AntonioAcosta B,Ana MHodgson B.,M Isabel Child nutrition disorders Hyperinsulinemia Hyperlipidemia Hypertension Obesity Background: Infantile obesity is a probable risk factor for the early appearance of chronic illnesses like Type 2 Diabetes Mellitus, Dislipidemia and Hypertension. Insulin Resistance (IR) appears as the common etiological mechanism. Aim: To describe metabolic complications associated to obesity in a group of Chilean children and to correlate them with IR, estimated through the homeostasis model assessment index (HOMA). Subjects and methods: We studied 88 children, 12±2.4 years old. Fifty two had severe obesity, 19 were overweight, and 17 had a normal weight (body mass index z score (BMIz): 4.7±1.6, 1.7±0.5 and 0.2±0.6 respectively, p <0.001). In obese children, an oral glucose tolerance test, measuring basal and 30 min insulin levels, was performed and serum lipid levels were measured. Results: Eleven percent of the severely obese children were glucose intolerant, 67% had basal hyperinsulinemia (>20 uU/ml) and 79% had IR (HOMA >3.8). These children also had a higher prevalence of acantosis nigricans than the overweight and normal counterparts (63, 10.5 and 0% respectively, p <0.001), higher basal insulinemia: (24.4±10, 16.4±4 and 12.2±3 mU/ml respectively) and HOMA (5.3±2, 3.4±0.8 and 2.3±0.5 respectively, p <0.001). By multiple stepwise regression analysis, BMIz was the only significant predictor for basal hyperinsulinemia, HOMA and diastolic blood pressure. Age and BMIz were independent predictors for systolic blood pressure. The strongest predictor for plasma lipid levels was the family history of dislipidemia. Conclusions: Obese children have a high prevalence of metabolic complications, which are related to the severity of obesity. Most of the severely obese children have hyperinsulinism and IR. BMIz is the principal predictor for high blood pressure. Familiar history is the better predictor for dislipidemia (Rev Méd Chile 2003; 131: 259-68).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.3 20032003-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300003es10.4067/S0034-98872003000300003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Child nutrition disorders Hyperinsulinemia Hyperlipidemia Hypertension Obesity
spellingShingle	Child nutrition disorders Hyperinsulinemia Hyperlipidemia Hypertension Obesity Barja Y,Salesa Arteaga Ll,Antonio Acosta B,Ana M Hodgson B.,M Isabel Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
description	Background: Infantile obesity is a probable risk factor for the early appearance of chronic illnesses like Type 2 Diabetes Mellitus, Dislipidemia and Hypertension. Insulin Resistance (IR) appears as the common etiological mechanism. Aim: To describe metabolic complications associated to obesity in a group of Chilean children and to correlate them with IR, estimated through the homeostasis model assessment index (HOMA). Subjects and methods: We studied 88 children, 12±2.4 years old. Fifty two had severe obesity, 19 were overweight, and 17 had a normal weight (body mass index z score (BMIz): 4.7±1.6, 1.7±0.5 and 0.2±0.6 respectively, p <0.001). In obese children, an oral glucose tolerance test, measuring basal and 30 min insulin levels, was performed and serum lipid levels were measured. Results: Eleven percent of the severely obese children were glucose intolerant, 67% had basal hyperinsulinemia (>20 uU/ml) and 79% had IR (HOMA >3.8). These children also had a higher prevalence of acantosis nigricans than the overweight and normal counterparts (63, 10.5 and 0% respectively, p <0.001), higher basal insulinemia: (24.4±10, 16.4±4 and 12.2±3 mU/ml respectively) and HOMA (5.3±2, 3.4±0.8 and 2.3±0.5 respectively, p <0.001). By multiple stepwise regression analysis, BMIz was the only significant predictor for basal hyperinsulinemia, HOMA and diastolic blood pressure. Age and BMIz were independent predictors for systolic blood pressure. The strongest predictor for plasma lipid levels was the family history of dislipidemia. Conclusions: Obese children have a high prevalence of metabolic complications, which are related to the severity of obesity. Most of the severely obese children have hyperinsulinism and IR. BMIz is the principal predictor for high blood pressure. Familiar history is the better predictor for dislipidemia (Rev Méd Chile 2003; 131: 259-68).
author	Barja Y,Salesa Arteaga Ll,Antonio Acosta B,Ana M Hodgson B.,M Isabel
author_facet	Barja Y,Salesa Arteaga Ll,Antonio Acosta B,Ana M Hodgson B.,M Isabel
author_sort	Barja Y,Salesa
title	Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
title_short	Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
title_full	Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
title_fullStr	Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
title_full_unstemmed	Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
title_sort	resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300003
work_keys_str_mv	AT barjaysalesa resistenciainsulinicayotrasexpresionesdelsindromemetabolicoenninosobesoschilenos AT arteagallantonio resistenciainsulinicayotrasexpresionesdelsindromemetabolicoenninosobesoschilenos AT acostabanam resistenciainsulinicayotrasexpresionesdelsindromemetabolicoenninosobesoschilenos AT hodgsonbmisabel resistenciainsulinicayotrasexpresionesdelsindromemetabolicoenninosobesoschilenos
_version_	1718436082254610432

Resistencia insulínica y otras expresiones del síndrome metabólico en niños obesos chilenos

Ejemplares similares