Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos

Background: Chronic lymphoproliferative disorders include a variety of diseases which are often a diagnostic problem for clinical hematologists. Aim: To study prospectively the distribution and incidence of chronic lymphoproliferative disorders in Chile and compare them with those of other Western,...

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Autores principales:	Cabrera C,María Elena, Marinov M,Neda, Guerra C,Carolina, Morilla,Ricardo, Matutes,Estella
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Leukemia-Lymphoma T-cell acute HTLV-1-associated Lymphoma, B-cell Lymphoproliferative disorders Lymphoma, T-cell
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300007
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spelling	oai:scielo:S0034-988720030003000072004-12-13Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casosCabrera C,María ElenaMarinov M,NedaGuerra C,CarolinaMorilla,RicardoMatutes,Estella Leukemia-Lymphoma T-cell acute HTLV-1-associated Lymphoma, B-cell Lymphoproliferative disorders Lymphoma, T-cell Background: Chronic lymphoproliferative disorders include a variety of diseases which are often a diagnostic problem for clinical hematologists. Aim: To study prospectively the distribution and incidence of chronic lymphoproliferative disorders in Chile and compare them with those of other Western, Latin American and Oriental countries. Patients and methods: A group of 132 patients were studied in a 36 months period (1999-2001), with a panel of monoclonal antibodies. A score for chronic lymphocytic leukemia was employed to differentiate it from other B-cell disorders. Results: The median age was 63 years old (range 32-94). Most patients had B-cell tumors (109) and the rest (23), T-cell tumors (82% vs 18%). Forty five percent of patients with B-cell tumors had a chronic lymphocytic leukemia (CLL), while the others were disseminated lymphomas. The incidence of T-cell tumors was slightly higher than that of other Western countries. Noteworthy is that the most common of these disorders was adult T cell leukemia/lymphoma (ATLL), in concordance with the high HTLV-1 seroprevalence in Chile. Conclusions: A morphologic, immunophenotypic and pathological study in a large number of patients with chronic lymphoproliferative disorders in Chile, shows a relatively low incidence of CLL when compared to other chronic B-cell tumors and a high representation of ATLL associated to HTLV-1 infection, compared with other Western countries. The lower incidence of CLL in our study might be due to patient's selection and/or underdiagnosis of this disease as a substantial proportion of CLL are asymptomatic (Rev Méd Chile 2003; 131: 291-8).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.3 20032003-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300007es10.4067/S0034-98872003000300007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Leukemia-Lymphoma T-cell acute HTLV-1-associated Lymphoma, B-cell Lymphoproliferative disorders Lymphoma, T-cell
spellingShingle	Leukemia-Lymphoma T-cell acute HTLV-1-associated Lymphoma, B-cell Lymphoproliferative disorders Lymphoma, T-cell Cabrera C,María Elena Marinov M,Neda Guerra C,Carolina Morilla,Ricardo Matutes,Estella Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
description	Background: Chronic lymphoproliferative disorders include a variety of diseases which are often a diagnostic problem for clinical hematologists. Aim: To study prospectively the distribution and incidence of chronic lymphoproliferative disorders in Chile and compare them with those of other Western, Latin American and Oriental countries. Patients and methods: A group of 132 patients were studied in a 36 months period (1999-2001), with a panel of monoclonal antibodies. A score for chronic lymphocytic leukemia was employed to differentiate it from other B-cell disorders. Results: The median age was 63 years old (range 32-94). Most patients had B-cell tumors (109) and the rest (23), T-cell tumors (82% vs 18%). Forty five percent of patients with B-cell tumors had a chronic lymphocytic leukemia (CLL), while the others were disseminated lymphomas. The incidence of T-cell tumors was slightly higher than that of other Western countries. Noteworthy is that the most common of these disorders was adult T cell leukemia/lymphoma (ATLL), in concordance with the high HTLV-1 seroprevalence in Chile. Conclusions: A morphologic, immunophenotypic and pathological study in a large number of patients with chronic lymphoproliferative disorders in Chile, shows a relatively low incidence of CLL when compared to other chronic B-cell tumors and a high representation of ATLL associated to HTLV-1 infection, compared with other Western countries. The lower incidence of CLL in our study might be due to patient's selection and/or underdiagnosis of this disease as a substantial proportion of CLL are asymptomatic (Rev Méd Chile 2003; 131: 291-8).
author	Cabrera C,María Elena Marinov M,Neda Guerra C,Carolina Morilla,Ricardo Matutes,Estella
author_facet	Cabrera C,María Elena Marinov M,Neda Guerra C,Carolina Morilla,Ricardo Matutes,Estella
author_sort	Cabrera C,María Elena
title	Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
title_short	Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
title_full	Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
title_fullStr	Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
title_full_unstemmed	Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos
title_sort	síndromes linfoproliferativos crónicos en chile: estudio prospectivo de 132 casos
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000300007
work_keys_str_mv	AT cabreracmariaelena sindromeslinfoproliferativoscronicosenchileestudioprospectivode132casos AT marinovmneda sindromeslinfoproliferativoscronicosenchileestudioprospectivode132casos AT guerraccarolina sindromeslinfoproliferativoscronicosenchileestudioprospectivode132casos AT morillaricardo sindromeslinfoproliferativoscronicosenchileestudioprospectivode132casos AT matutesestella sindromeslinfoproliferativoscronicosenchileestudioprospectivode132casos
_version_	1718436083281166336

Síndromes linfoproliferativos crónicos en Chile: Estudio prospectivo de 132 casos

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