Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica

Background: The different therapeutic schedules used for the prescription of digoxin have little theoretical support. Aim: To measure digoxin plasma levels in patients using four different prescription schedules. Patients and methods: Four groups of patients were studied. Group I corresponded to 56...

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Autores principales:	Reinbach H,Rolando, Villa Z,Lorenzo, Giraudo T,Paolo, Venegas A,Reinaldo, Fernández R,Pola
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Cardiotonic agents Digoxin Pharmacokinetics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400004
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spelling	oai:scielo:S0034-988720030004000042004-12-13Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínicaReinbach H,RolandoVilla Z,LorenzoGiraudo T,PaoloVenegas A,ReinaldoFernández R,Pola Cardiotonic agents Digoxin Pharmacokinetics Background: The different therapeutic schedules used for the prescription of digoxin have little theoretical support. Aim: To measure digoxin plasma levels in patients using four different prescription schedules. Patients and methods: Four groups of patients were studied. Group I corresponded to 56 patients taking digoxin 0.25 mg/day, from Monday to Friday. Group II corresponded to 30 patients taking digoxin 0.25 mg/day, from Monday to Saturday. Group III corresponded to 53 patients taking digoxin 0.25 mg/day continuosly. Group IV corresponded to 36 patients taking digoxin 0.125 mg/day continuosly. Plasma digoxin levels were measured in two consecutive Mondays before taking the daily dose of the drug. Serum creatinine was also measured and creatinine clearance was calculated. The therapeutic plasma concentration range was set between 0.5 and 2 ng/ml. Results: Mean plasma digoxin levels were 1.15±0.8 ng/ml in group I, 1.4±0.55 ng/ml in group II, 1.68±0.7 ng/ml in group III and 1.14±0.43 ng/ml in group IV. 93% of patients in group I, 80% of patients in group II, 75% of patients in group III and 94% of patients in group IV had therapeutic digoxin levels. A low creatinine clearance, an age over 65 and interactions with other drugs were risk factors associated with supratherapeutic levels, mostly seen in group II and group III with 20% and 24% respectively. Conclusions: Most patients using digoxin with different therapeutic schedules had plasma drug levels within the therapeutic range (Rev Méd Chile 2003; 131: 373-80).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.4 20032003-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400004es10.4067/S0034-98872003000400004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cardiotonic agents Digoxin Pharmacokinetics
spellingShingle	Cardiotonic agents Digoxin Pharmacokinetics Reinbach H,Rolando Villa Z,Lorenzo Giraudo T,Paolo Venegas A,Reinaldo Fernández R,Pola Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
description	Background: The different therapeutic schedules used for the prescription of digoxin have little theoretical support. Aim: To measure digoxin plasma levels in patients using four different prescription schedules. Patients and methods: Four groups of patients were studied. Group I corresponded to 56 patients taking digoxin 0.25 mg/day, from Monday to Friday. Group II corresponded to 30 patients taking digoxin 0.25 mg/day, from Monday to Saturday. Group III corresponded to 53 patients taking digoxin 0.25 mg/day continuosly. Group IV corresponded to 36 patients taking digoxin 0.125 mg/day continuosly. Plasma digoxin levels were measured in two consecutive Mondays before taking the daily dose of the drug. Serum creatinine was also measured and creatinine clearance was calculated. The therapeutic plasma concentration range was set between 0.5 and 2 ng/ml. Results: Mean plasma digoxin levels were 1.15±0.8 ng/ml in group I, 1.4±0.55 ng/ml in group II, 1.68±0.7 ng/ml in group III and 1.14±0.43 ng/ml in group IV. 93% of patients in group I, 80% of patients in group II, 75% of patients in group III and 94% of patients in group IV had therapeutic digoxin levels. A low creatinine clearance, an age over 65 and interactions with other drugs were risk factors associated with supratherapeutic levels, mostly seen in group II and group III with 20% and 24% respectively. Conclusions: Most patients using digoxin with different therapeutic schedules had plasma drug levels within the therapeutic range (Rev Méd Chile 2003; 131: 373-80).
author	Reinbach H,Rolando Villa Z,Lorenzo Giraudo T,Paolo Venegas A,Reinaldo Fernández R,Pola
author_facet	Reinbach H,Rolando Villa Z,Lorenzo Giraudo T,Paolo Venegas A,Reinaldo Fernández R,Pola
author_sort	Reinbach H,Rolando
title	Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
title_short	Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
title_full	Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
title_fullStr	Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
title_full_unstemmed	Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
title_sort	concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400004
work_keys_str_mv	AT reinbachhrolando concentracionesplasmaticasdedigoxinaencuatroesquemasterapeuticosdeusocomunenlapracticaclinica AT villazlorenzo concentracionesplasmaticasdedigoxinaencuatroesquemasterapeuticosdeusocomunenlapracticaclinica AT giraudotpaolo concentracionesplasmaticasdedigoxinaencuatroesquemasterapeuticosdeusocomunenlapracticaclinica AT venegasareinaldo concentracionesplasmaticasdedigoxinaencuatroesquemasterapeuticosdeusocomunenlapracticaclinica AT fernandezrpola concentracionesplasmaticasdedigoxinaencuatroesquemasterapeuticosdeusocomunenlapracticaclinica
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Concentraciones plasmáticas de digoxina en cuatro esquemas terapéuticos de uso común en la práctica clínica

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