Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos

Background: Clostridium difficile is the main agent causing antimicrobial associated nosocomial diarrhea. Chronic renal failure is a risk factor for this type of diarrhea. Aim: To study the incidence and complications of Clostridium difficile diarrhea in a university hospital and among patients with...

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Autores principales:	Herrera R,Patricia, Cotera F,Alejandro, Fica C,Alberto, Galdo A,Teresa, Alvo A.,Miriam
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Clostridium difficile Enterocolitis pseudomembranous Kidney failure chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400007
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spelling	oai:scielo:S0034-988720030004000072004-12-13Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicosHerrera R,PatriciaCotera F,AlejandroFica C,AlbertoGaldo A,TeresaAlvo A.,Miriam Clostridium difficile Enterocolitis pseudomembranous Kidney failure chronic Background: Clostridium difficile is the main agent causing antimicrobial associated nosocomial diarrhea. Chronic renal failure is a risk factor for this type of diarrhea. Aim: To study the incidence and complications of Clostridium difficile diarrhea in a university hospital and among patients with renal diseases. Patients and methods: Retrospective review of all cases of Clostridium difficile diarrhea that occurred in a university hospital, between June 2000 and May 2001. Results: In the Nephrology Unit, 48 episodes of Clostridium difficile diarrhea occurred in 35 patients (7 cases per 100 discharges/year). This figure is higher than the global incidence in the hospital (0.53 cases per 100 discharges/year, p <0.001). The mean age of the 33 patients with renal diseases was 63 years old and 17 of them were female. Their main diagnoses were chronic renal failure in hemodialysis in 48%, uremic syndrome in 36% and renal transplant in 6%. Seventy nine percent had a history of antimicrobial use (42% quinolones and 36% cephalosporins). In 3 patients, the only risk factor was chronic renal failure. Seventy five percent responded to metronidazole and in 27%, diarrhea recidivated, compared with a 6% recurrence rate in other units, p <0.02). Eight patients died during hospital stay. Conclusions: Among patients with renal diseases, Clostridium difficile is frequent and associated with a high recurrence rate and mortality. Chronic renal failure may be a risk factor for its development (Rev Méd Chile 2003; 131: -).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.4 20032003-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400007es10.4067/S0034-98872003000400007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Clostridium difficile Enterocolitis pseudomembranous Kidney failure chronic
spellingShingle	Clostridium difficile Enterocolitis pseudomembranous Kidney failure chronic Herrera R,Patricia Cotera F,Alejandro Fica C,Alberto Galdo A,Teresa Alvo A.,Miriam Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
description	Background: Clostridium difficile is the main agent causing antimicrobial associated nosocomial diarrhea. Chronic renal failure is a risk factor for this type of diarrhea. Aim: To study the incidence and complications of Clostridium difficile diarrhea in a university hospital and among patients with renal diseases. Patients and methods: Retrospective review of all cases of Clostridium difficile diarrhea that occurred in a university hospital, between June 2000 and May 2001. Results: In the Nephrology Unit, 48 episodes of Clostridium difficile diarrhea occurred in 35 patients (7 cases per 100 discharges/year). This figure is higher than the global incidence in the hospital (0.53 cases per 100 discharges/year, p <0.001). The mean age of the 33 patients with renal diseases was 63 years old and 17 of them were female. Their main diagnoses were chronic renal failure in hemodialysis in 48%, uremic syndrome in 36% and renal transplant in 6%. Seventy nine percent had a history of antimicrobial use (42% quinolones and 36% cephalosporins). In 3 patients, the only risk factor was chronic renal failure. Seventy five percent responded to metronidazole and in 27%, diarrhea recidivated, compared with a 6% recurrence rate in other units, p <0.02). Eight patients died during hospital stay. Conclusions: Among patients with renal diseases, Clostridium difficile is frequent and associated with a high recurrence rate and mortality. Chronic renal failure may be a risk factor for its development (Rev Méd Chile 2003; 131: -).
author	Herrera R,Patricia Cotera F,Alejandro Fica C,Alberto Galdo A,Teresa Alvo A.,Miriam
author_facet	Herrera R,Patricia Cotera F,Alejandro Fica C,Alberto Galdo A,Teresa Alvo A.,Miriam
author_sort	Herrera R,Patricia
title	Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
title_short	Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
title_full	Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
title_fullStr	Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
title_full_unstemmed	Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos
title_sort	alta incidencia de diarrea por clostridium difficile en pacientes nefrológicos
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000400007
work_keys_str_mv	AT herrerarpatricia altaincidenciadediarreaporclostridiumdifficileenpacientesnefrologicos AT coterafalejandro altaincidenciadediarreaporclostridiumdifficileenpacientesnefrologicos AT ficacalberto altaincidenciadediarreaporclostridiumdifficileenpacientesnefrologicos AT galdoateresa altaincidenciadediarreaporclostridiumdifficileenpacientesnefrologicos AT alvoamiriam altaincidenciadediarreaporclostridiumdifficileenpacientesnefrologicos
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Alta incidencia de diarrea por Clostridium difficile en pacientes nefrológicos

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